Nazgul Sakenova
@nazgulsakenova.bsky.social
📤 248
đź“Ą 69
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PostDoc at Harvard PhD
@typaslab.bsky.social
pinned post!
My PhD work is now published in Nature Microbiology! Please, have a look!
add a skeleton here at some point
10 months ago
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Nazgul Sakenova
Goemans Lab
5 months ago
How the
@embo.org
postdoctoral fellowship helped me in developing my academic career... happy to see my profile featured on the EMBO website!
www.embo.org/people/from-...
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From Fellowship to Frontline: Camille Goemans’ Mission to Tackle Antibiotic Resistance – People – EMBO
An interview with Camille Goemans, tenure-track assistant professor at the École Polytechnique Fédérale de Lausanne (EPFL) in Lausanne, Switzerland and former EMBO Postdoctoral Fellow
https://www.embo.org/people/from-fellowship-to-frontline-camille-goemans-mission-to-tackle-antibiotic-resistance/
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Nazgul Sakenova
Savitski Lab
5 months ago
Want to know how the ligands interact with proteins beyond model cell lines, e.g., in tissues or bacteria? Interested in membrane targets? Check out our High-Throughput PELSA method which allows you do all these cool screenings for dozens of ligands within two hours!
www.biorxiv.org/content/10.1...
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High-throughput peptide-centric local stability assay extends protein-ligand identification to membrane proteins, tissues, and bacteria
Systematic mapping of protein-ligand interactions is essential for understanding biological processes and drug mechanisms. Peptide-centric local stability assay (PELSA) is a powerful tool for detectin...
https://www.biorxiv.org/content/10.1101/2025.04.28.650974v1
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Nazgul Sakenova
Alf Soler-Bistué 🦠🔬🧫
6 months ago
I was waiting two years to see this out!! The genomic location of bacterial genes is not random!!! Congratulation on the authors (Martin Lercher and Team!).
www.science.org/doi/10.1126/...
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Most bacterial gene families are biased toward specific chromosomal positions
The arrangement of genes along bacterial chromosomes influences their expression through growth rate–dependent gene copy number changes during DNA replication. Although translation- and transcription-...
https://www.science.org/doi/10.1126/science.adm9928#tab-contributors
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Nazgul Sakenova
Csaba Pal Laboratory
8 months ago
Thrilled to share our latest work, "Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance" in Science Translational Medicine! For details, see the thread below and read the paper here:
www.science.org/doi/10.1126/...
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Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance
Antibiotic candidates induce multidrug resistance in Staphylococcus aureus without compromising bacterial viability.
https://www.science.org/doi/10.1126/scitranslmed.adl2103
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I attended the course in 2022, as it’s held every three years. It combines diverse, exciting science with close-knit socializing on a beautiful Greek island. Highly recommended for PhD students at any stage!
add a skeleton here at some point
9 months ago
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Nazgul Sakenova
Nature Portfolio
10 months ago
Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. A study in Nature Microbiology presents an approach to systematically discover and understand such antibiotic relationships.
https://go.nature.com/49of3Mk
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Nazgul Sakenova
EMBL
10 months ago
(1/3) Antibiotic resistance is costing human lives. 🦠A study from EMBL's Typas group proposed a framework to identify antibiotic pairs that make bacteria resistant to one antibiotic but sensitive to other – this can help design new treatments and delay resistance. 🧬🧪
www.nature.com/articles/s41...
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My PhD work is now published in Nature Microbiology! Please, have a look!
add a skeleton here at some point
10 months ago
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Antibiotic (abx) resistance is outpacing new abx discovery. This is worsened by cross-resistance (XR) between abx. However, resistance can also lead to collateral sensitivity (CS) to other abx, providing new treatment opportunities. In our new preprint
www.biorxiv.org/content/10.1...
over 1 year ago
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