@zhaolabucr.bsky.social
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Congratulations to Dr. Anal Jana & Yu Hsuan Chen on publishing our work on a novel mitochondria-targeting probe for manipulating mitochondrial DNA
@angewandtechemie.bsky.social
Thanks to
@ucriverside.bsky.social
for providing funding for open access!
onlinelibrary.wiley.com/doi/10.1002/...
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Mitochondria‐Targeting Abasic Site‐Reactive Probe (mTAP) Enables the Manipulation of Mitochondrial DNA Levels
Mitochondrial DNA (mtDNA) encodes essential genes for mitochondrial and cellular functions and acts as a cell signaling molecule in innate immune and inflammatory responses. Defects in mtDNA are impl...
https://onlinelibrary.wiley.com/doi/10.1002/anie.202502470
3 months ago
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Congrats to Dr. Anal Jana and Yu Hsuan Chen for developing and validating a mitochondria-targeting probe that can rescue mtDNA damage-induced mtDNA level decrease!
chemrxiv.org/engage/chemr...
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Mitochondria-targeting abasic site-reactive probe (mTAP) enables the manipulation of mitochondrial DNA repair and turnover
Mitochondrial DNA (mtDNA) encodes essential protein subunits in the oxidative phosphorylation system and a set of tRNAs and rRNAs, making it critical for mitochondrial and cellular functions. Defects ...
https://chemrxiv.org/engage/chemrxiv/article-details/67f4019b81d2151a0267c701
6 months ago
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Happy to share our new story on the role of TFAM in regulating mitochondrial DNA repair and lesion accumulation.
academic.oup.com/nar/advance-...
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DNA sequence and lesion-dependent mitochondrial transcription factor A (TFAM)-DNA-binding modulates DNA repair activities and products
Abstract. Mitochondrial DNA (mtDNA) is indispensable for mitochondrial function and is maintained by DNA repair, turnover, mitochondrial dynamics and mitop
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae1144/7912043?login=false
10 months ago
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