We’re excited to share a Postdoc Opening in the Burkard Lab @iowa /Holden Cancer Center. The fellow will study mitotic regulation in normal & cancer cells, exploring drug response & resistance in human samples, organoids, & preclinical models. Spread the word! 📅 Apply by 3/1/26 📧 [email protected]

Want better resolution of small chromatin / subnuclear structures? Our new method, One-step 4× and 12× 3D-ExM, improves super-resolution microscopy in both 2D and 3D cell culture. Useful for labs studying kinetochores, nuclear pores, chromosomes, etc. #methods #microscopy #cellbiology

Chromosomal instability is everywhere in cancer biology—but how do we actually measure it? Our 2024 review The Reckoning of CIN: Past, Present, Future (Lynch, Bradford, Burkard et al.) digs into the methods, pitfalls, and what’s coming next. #CIN #Aneuploidy #CancerBiology

Measuring chromosomal instability #CIN isn’t straightforward. We compared live imaging, FISH, scDNA-seq & other assays, and found significant differences. Our take: Use mis-segregations per diploid division (MDD) as a clear standard. www.pnas.org/doi/10.1073/...

👋 Welcome to the Burkard Lab! We study how errors in mitosis cause chromosomal instability and aneuploidy. Our projects span mitotic regulators like PLK1 as well as how aneuploidy shapes cancer and cell fitness. Follow us for research updates and lab life at Iowa!

We’re excited to share a Postdoc Opening in the Burkard Lab @iowa /Holden Cancer Center. The fellow will study mitotic regulation in normal & cancer cells, exploring drug response & resistance in human samples, organoids, & preclinical models. Spread the word! 📅 Apply by 3/1/26 📧 [email protected]

Measuring chromosomal instability #CIN isn’t straightforward. We compared live imaging, FISH, scDNA-seq & other assays, and found significant differences. Our take: Use mis-segregations per diploid division (MDD) as a clear standard. www.pnas.org/doi/10.1073/...

Chromosomal instability is everywhere in cancer biology—but how do we actually measure it? Our 2024 review The Reckoning of CIN: Past, Present, Future (Lynch, Bradford, Burkard et al.) digs into the methods, pitfalls, and what’s coming next. #CIN #Aneuploidy #CancerBiology

Want better resolution of small chromatin / subnuclear structures? Our new method, One-step 4× and 12× 3D-ExM, improves super-resolution microscopy in both 2D and 3D cell culture. Useful for labs studying kinetochores, nuclear pores, chromosomes, etc. #methods #microscopy #cellbiology

New from the Burkard Lab: Polo-like kinase 1 maintains transcription & chromosomal accessibility during mitosis.We show PLK1 is vital not just for mitotic machinery but for keeping promoter/TSS regions accessible & transcription active. Check it out www.molbiolcell.org/doi/10.1091/... #mitosis #plk1

👋 Welcome to the Burkard Lab! We study how errors in mitosis cause chromosomal instability and aneuploidy. Our projects span mitotic regulators like PLK1 as well as how aneuploidy shapes cancer and cell fitness. Follow us for research updates and lab life at Iowa!