Stefan Niekamp (@niekamp.bsky.social)

Excited to share our latest work in Molecular Cell: www.cell.com/molecular-ce... We show that PRC1 condensates exclude SWI/SNF from chromatin, revealing a physical mechanism for how opposing regulators compete to control gene expression. Huge thanks to all collaborators and mentors!

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Mutual antagonism between PRC1 condensates and SWI/SNF in chromatin regulation Niekamp et al. show that biomolecular condensates formed by Polycomb repressive complexes can physically restrict access of the activating remodeler SWI/SNF to chromatin. Establishing this barrier dep... https://www.cell.com/molecular-cell/fulltext/S1097-2765(26)00235-2