Madison Chapel
@chapelmadison.bsky.social
📤 23
📥 15
📝 27
MSc, bioinformatics (UBC) Head full of yarn scraps, bloodstream full of bubble tea
1/ Why are eukaryotic gene regulatory networks (GRNs) so much more complex than prokaryotic ones? In our new preprint, we investigated the role that recombination – a key step in eukaryotic reproductive strategies – plays in this problem!
www.biorxiv.org/content/10.1...
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Evolutionary simulations reveal role for genomic recombination in the evolution of gene regulatory network complexity and robustness
The gene regulatory networks (GRNs) of eukaryotes are dramatically more complex than the GRNs of prokaryotes, but we lack a complete picture of the selective pressures that have shaped this difference...
https://www.biorxiv.org/content/10.1101/2025.08.28.672878v1
4 months ago
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1/ Interested in how genetic variants influence complex traits? In our new preprint, we show that variant effects depend on the polygenic background in which they occur, and why it is critical to consider polygenic background when studying complex traits.
www.biorxiv.org/content/10.1...
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Variant effects depend on polygenic background: experimental, clinical, and evolutionary implications
Both rare and common genetic variants contribute to human disease, and emerging evidence suggests that they combine additively to influence disease liability. However, due to the non-linear relationsh...
https://www.biorxiv.org/content/10.1101/2025.01.07.631805v1
12 months ago
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