Babis Pappas
@pappasgroup.bsky.social
📤 376
📥 144
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Phosphates, Chemical Reaction Networks, Self-Assembly
https://pappasresearchgroup.com/
Just out in
@chemrxiv.org
Click or Acyl transfer? We show how amino acyl phosphates and peptide nucleophiles direct acyl transfer vs click chemistry, enabling temporal control in abiotic networks. Well done
@debjyoti8419.bsky.social
chemrxiv.org/engage/chemr...
21 days ago
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Happy to see the work from
@lenardsaile.bsky.social
and Kun Dai highlighted
#onTheCover
of @angew_chem (inside back cover). Thanks @EllaMaru for the great design. Chiral aminoacyl phosphates!!!
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/10.1002/...
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Inside Back Cover: Chirality Makes or Breaks Chemically Driven Self‐Assembly
In their Research Article (e202508481), Lenard Saile and Kun Dai et al. describe a feedback mechanism that controls non-equilibrium systems. Enantiomeric aminoacyl phosphates, depicted as left and ri...
https://onlinelibrary.wiley.com/doi/10.1002/ange.202518660
about 1 month ago
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We are happy to share that our article on chirality-driven non-equilibrium assembly is published in
@angewandtechemie.bsky.social
!Congrats to Lenard and Kun for showing how left and right handed aminoacyl phosphates enable control over kinetics and pathways
onlinelibrary.wiley.com/doi/10.1002/an…
2 months ago
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We are very happy to share our recent publication in
@cp-chem.bsky.social
on abiotic aminoacylation and side chain recognition through compartmentalization! Congrats to Kun and Lenard, and everyone else involved in the work!
www.cell.com/chem/fulltex...
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Phase behavior and pathway-selective oligomerization driven by amino acid side-chain recognition
What basic ingredients enable amino acid side-chain recognition and assembly without complex biological machinery? We show that even simple molecular sorters can organize amino acids in space and time...
https://www.cell.com/chem/fulltext/S2451-9294(25)00179-2
5 months ago
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We are looking for a postdoctoral researcher to work on a project funded by the Boehringer Ingelheim Foundation on dynamic peptide self-assembly. 📄 Full position ad:
bit.ly/4jAIrmg
📅 Application deadline: May 31, 2025
#Postdoc
#ChemistryJobs
#SystemsChemistry
#AcademicJobs
#Freiburg
#livMatS
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http://bit.ly/4jAIrmg
6 months ago
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Congratulations Mahesh for successfully defending your thesis! The first PhD student from the group. An amazing research journey ends here and we wish you all the best for your future research adventures!!
8 months ago
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Happy for our published article in @NatureComms showing the departure from randomness in peptide bond formation through aminoacyl phosphate esters. Congratulations to Arti and everyone involved.@livMatS_UniFR @UniFreiburg @FreiburgChem @FitFreiburg
nature.com/articles/s41...
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Selective peptide bond formation via side chain reactivity and self-assembly of abiotic phosphates - Nature Communications
In biological processes, peptide bonds are formed via reactive phosphate-containing intermediates, facilitated by compartmentalized environments. Here, the authors use aminoacyl phosphate esters that ...
https://nature.com/articles/s41467-025-56432-6
8 months ago
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We have a PhD position on reaction networks driven by aminoacyl phosphate esters funded from
@ercresearch.bsky.social
at
@uni-freiburg.de
. Deadline for application is 20/03/25. More information can be found here:
static1.squarespace.com/static/5fc39...
8 months ago
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