Excited to share our new review/perspective on how metabolic (and cellular) context shapes enzyme evolution. pubs.acs.org/doi/10.1021/...

After 17 years at UT Southwestern (first as a postdoc, and then starting my lab), I'm excited to be starting a new chapter in The Jenkins Department of Biophysics, at Johns Hopkins University UTSW friends and colleagues, I will miss you very much!

New preprint! We carried out the largest complementation and inhibition study for diverse homologs in a single protein family (DHFR) to date. Highlights thread follows... 1/n 🧵

Combining experiment and computation to tackle scientific problems in the microbial world? Consider applying for our tenure track faculty search in microbial systems biology. Application deadline coming up, Nov 29.

Announcing a new tenure-track faculty search in microbial systems biology! Come join a fantastic ecosystem of systems biologists and informaticians. Application deadline is Nov 29. To apply: apply.interfolio.com/154339

Physical protein interactions constrain interface sequence. But what about non-binding "biochemical" interactions in metabolism? We used deep mutational scanning to map sequence constraints for two enzymes that catalyze consecutive metabolic reactions: rdcu.be/dE7xl

Our new work on (1) mapping genetic interactions in E. coli with titratable CRISPRi and then (2) using these data to build predictive gene expression -> growth rate models is out now in Cell Systems! doi.org/10.1016/j.ce...

Come join us! We're looking for not just one, but two postdoctoral fellows. We have one position open in biosynth pathway optimization, and another to examine how E. coli responds to perturbations in essential gene abundance. For details: www.utsouthwestern.edu/research/pos...

We're hiring a new faculty member in Clinical Informatics! Read more and apply at the link. cu.taleo.net/careersectio...