Sara Pretorius and colleagues review UK guidelines for individual health conditions and propose improvements to guideline development processes to improve usability of guidelines for clinicians managing patients with multiple long term conditions https://bit.ly/4slFri8

Estimates of multimorbidity range from 15-43% of the adult population, and most people with one long term condition have more than one. How well do guidelines account for this? How often do they offer specific guidance on how to manage long term conditions that may be affected by comorbidities?🧵

Barbara Nicholl and colleagues reflect on how clinical guidelines largely focus on single diseases and are inadequate for the care required by people with multiple long-term conditions Read the full Editorial in BMJ Medicine: https://bit.ly/4tWorAy

How did you get on with our stats question? Was it too mean? Here are the answers🧵

In this study Sara Pretorius and colleagues evaluate how UK guidelines for individual health conditions account for coexisting conditions and propose changes to guideline development to improve care for people with multiple long term conditions https://bit.ly/4sczrYK

Explore our Methods Primers Collection, where all resources in this area are conveniently organized for your reference https://bit.ly/45vZb9G

Fancy a stats quiz? Read through the example and answer the questions in the thread below 🧵

New research📢 Geertruida Bekkering and colleagues compare the effectiveness and safety of pharmacological and non-pharmacological smoking cessation interventions in people with severe mental illness. https://bit.ly/4kHE8Ye

A new Methods Primer by Dan Green and colleagues outlines circumstances where the mean and standard deviation alone are insufficient summary variables, and provides a simple appraisal method for reviewers without raw data Read in BMJ Medicine now: https://bit.ly/4bJz3w8

Walker and Lee reflect on a study by Faye Cleary and colleagues that presents a new kidney failure risk equation that doesn't need albuminuria testing, saying it has potential to improve health equity but albuminuria testing is important beyond predicting kidney failure https://bit.ly/4bJz3w8

A new study from Faye Cleary and colleagues presents a new risk prediction equation for kidney failure in patients with chronic kidney disease who do not require data for the urine albumin to creatinine ratio Read the full study here: https://bit.ly/4qtOpsr

Take a look at our open access specialist reviews, in one handy Collection for you to browse anytime https://bit.ly/3YpbpgB

Yuanyuan Zhang and colleagues compare the efficacy and safety of different intensive systolic blood pressure targets versus usual care on cardiovascular and renal outcomes in high risk patients https://bmjmedicine.bmj.com/content/5/1/e001791

In this new study, Yu-En Chen and colleagues found that time restricted eating overall improved metabolic health outcomes compared with usual diets, and early time restricted eating was superior to late time restricted eating. Read the full study here: https://bit.ly/4jY06FV

New Year, New you. If your resolution involves hitting the gym, you're on the right track! Han Han and colleagues' findings support the notion that habitual engagement in a diverse range of physical activities is associated with lower mortality. https://bit.ly/4jSKy6v

What are the optimal types of time restricted eating? Yu-En Chen and colleagues evaluate the effect of overall time restricted eating on metabolic health outcomes in their new study. https://bit.ly/4jY06FV

A new study by Edmund Lamb and colleagues dives into two sets of estimating equations, using single and combined creatinine/cystatin C biomarkers to assess their accuracy in patients with moderate chronic kidney disease. https://bit.ly/4jSWhBP #CKD #MedicalResearch

Does your workout variety matter for long-term health? New research from Han Han and colleagues examines the associations of long term engagement in individual physical activities and physical activity variety with the risk of death. https://bit.ly/4jSKy6v

Explore our Methods Primers Collection, where all resources in this area are conveniently organized for your reference https://bit.ly/45vZb9G

Huseyin Naci and colleagues assess survival gains and additional Medicare spending associated with early access to new cancer drugs through the US FDA's accelerated approval pathway, examining the benefits and costs of earlier access. https://bit.ly/4jtsqQt

Are you conducting a case study in 2026? Here are some tips from @trishgreenhalgh.bsky.social's guide to case studies, published in BMJ Medicine. 🧵

New research by Huseyin Naci and colleagues weighs up the cost and benefit of early access to new cancer drugs through the US FDA’s accelerated approval pathway, compared to access to cancer drugs following completion of confirmatory trials https://bit.ly/4q374f1

🔥 The #ClimateEmergency is a health emergency too. We're calling for your #research and #editorials exploring the climate–health connection. Hear more from our EiC and get involved by browsing our latest articles https://bit.ly/48Zzuki

In this study, Rose Higgins and colleagues look at opioid prescribing in patients on orthopaedic waiting lists during the pandemic to understand the impact of longer elective wait times. https://bmjmedicine.bmj.com/content/4/1/e001743

The COVID-19 vaccine trials were fast, but highlighted a critical gap in health equity. Alice Taylor and colleagues argue that people living in sub-Saharan Africa are underrepresented in the global population of study participants for clinical trials. https://bit.ly/4iGU1Nr

🔍 We can’t afford to overlook the crucial issue of Content Integrity. BMJ Medicine upholds ethical standards and assesses content—especially in the era of #AItools. Find out more about content integrity at BMJ https://bit.ly/4q1igJu

A new study by Rose Higgins and colleagues quantifies changes in opioid prescribing in people on orthopaedic waiting lists to understand the impact of longer elective wait times during the covid-19 pandemic. https://bit.ly/3YjUHyX #Opioids #Covid19

A new opinion article by Alice Taylor and colleagues argues that people living in sub-Saharan Africa are underrepresented and their ethnicity often misrepresented in the global population of study participants for clinical trials for vaccines Read now: https://bit.ly/4iGU1Nr

How does household size play a role in the association between multimorbidity and health and social care outcomes in older adults? Read this new study by Clare MacRae and colleagues to find out: https://bit.ly/4apIxf6

What’s been happening to hypertension prevalence and control in England over the last 20 years? A study from researchers @qmul.bsky.social, recently published in BMJ Medicine, has mixed news. 🧵

How have hypertension trends changed over the last two decades? Catherine Graham and colleagues determine annual trends in hypertension diagnosis, true hypertension prevalence, and control and use of antihypertensive drugs in England. https://bit.ly/4oCb0SE

🔥 The #ClimateEmergency is a health emergency too. We're calling for your #research and #editorials exploring the climate–health connection. Hear more from our EiC and get involved by browsing our latest articles https://bit.ly/48Zzuki

@bmj.com & @bmjmedicine.bsky.social -

Ever wondered what it’s like to work on a medical journal? Our EiC, Sophie Cook, shares how she got started in publishing. #Publishing #EditorialRoles #CareerInPublishing

Is the evidence there for whole genome sequencing screening for newborns? Karoline Freeman and colleagues examine the challenges with current evidence synthesis and provide a roadmap for future evidence generation. https://bit.ly/47ZFUPQ

A new linked editorial by Ethan Nella and Jennifer Couturier reflects on the cohort study by Catharine Morgan and colleagues, highlighting the importance of recognising and managing risks in patients diagnosed with eating disorders https://bit.ly/4oZnwwA

How do eating disorders affect health outcomes in patients? Catharine Morgan and colleagues examine the short and long term adverse physical and mental health outcomes, all cause mortality, and deaths in individuals with a diagnosis of an eating disorder https://bit.ly/3KdOwck

From Trials and Cohort Studies to Methods Primers & Specialist Reviews, our content spans a wide range of articles. If your work impacts practice & enhances patient care, it may find a home with us. Learn more on our author pages #submissions https://bit.ly/4qiiGeX

Antimuscarinic bladder drugs are often avoided in older people due to concerns about effects on cognitive decline and dementia. A study published in January in BMJ Medicine challenged findings from previous observational studies on this association.🧵

New research by Corita Grudzen and colleagues finds no clear evidence that nurse led telephonic palliative care improved quality of life, or any secondary outcomes, relative to specialty outpatient palliative care. Read the full paper here: https://bit.ly/3Xrms8l

Corita Grudzen and colleagues compare the effectiveness of nurse led telephonic palliative care with specialty outpatient palliative care on quality of life, symptom burden, loneliness, and healthcare use, after attending the emergency department. https://bit.ly/3Xrms8l

🔍 We can’t afford to overlook the crucial issue of Content Integrity. BMJ Medicine upholds ethical standards and assesses content—especially in the era of #AItools. Find out more about content integrity at BMJ https://bit.ly/4q1igJu

The annual ‘winter pressures’ season is upon us. A year ago a cohort study in BMJ Medicine highlighted the role of multimorbidity on winter hospital admissions. Let’s take a look. 🧵

Did you know we publish material from Clinical Trials and Systematic Reviews to Methods Primers and Specialist Reviews? If your research improves patient care, we want to hear from you. Visit our author pages to get started: https://bit.ly/4qiiGeX

One of the first studies published in BMJ Medicine examined the safety of ezetimibe in lipid-lowering treatment. Ezetimibe prescribing has increased since this paper was published in 2022, following updated NICE lipid modification guidelines in 2023. So, what did the study by Wang el al. find? 🧵

In a new Methods Primer @danlewer.bsky.social and colleagues explain why when studying risk factors for health outcomes, looking at results that are statistically significant after mutual adjustment in a multivariable regression model can lead us astray. https://bit.ly/3JzNTJI

We wrote an article explaining why you shouldn't put several variables into a regression model and report which are statistically significant - even as exploratory research. bmjmedicine.bmj.com/content/4/1/.... How did we do?

🌍 How does climate affect health? We’d love to see your #research and #editorials on this crucial topic. Our Editor-in-chief shares insights on the #ClimateEmergency—join the conversation, see our latest climate research articles https://bit.ly/48Zzuki

Check out our starter pack: go.bsky.app/UzGUsD2 #MedSky #BMJMedicine#TheBMJ

Ever wondered what it’s like to work on a medical journal? Our EiC, Sophie Cook, shares how she got started in publishing. #Publishing #EditorialRoles #CareerInPublishing