Huseyin Naci and colleagues assess survival gains and additional Medicare spending associated with early access to new cancer drugs through the US FDA's accelerated approval pathway, examining the benefits and costs of earlier access. https://bit.ly/4jtsqQt

Are you conducting a case study in 2026? Here are some tips from @trishgreenhalgh.bsky.social's guide to case studies, published in BMJ Medicine. 🧵

New research by Huseyin Naci and colleagues weighs up the cost and benefit of early access to new cancer drugs through the US FDA’s accelerated approval pathway, compared to access to cancer drugs following completion of confirmatory trials https://bit.ly/4q374f1

🔥 The #ClimateEmergency is a health emergency too. We're calling for your #research and #editorials exploring the climate–health connection. Hear more from our EiC and get involved by browsing our latest articles https://bit.ly/48Zzuki

In this study, Rose Higgins and colleagues look at opioid prescribing in patients on orthopaedic waiting lists during the pandemic to understand the impact of longer elective wait times. https://bmjmedicine.bmj.com/content/4/1/e001743

The COVID-19 vaccine trials were fast, but highlighted a critical gap in health equity. Alice Taylor and colleagues argue that people living in sub-Saharan Africa are underrepresented in the global population of study participants for clinical trials. https://bit.ly/4iGU1Nr

🔍 We can’t afford to overlook the crucial issue of Content Integrity. BMJ Medicine upholds ethical standards and assesses content—especially in the era of #AItools. Find out more about content integrity at BMJ https://bit.ly/4q1igJu

A new study by Rose Higgins and colleagues quantifies changes in opioid prescribing in people on orthopaedic waiting lists to understand the impact of longer elective wait times during the covid-19 pandemic. https://bit.ly/3YjUHyX #Opioids #Covid19

A new opinion article by Alice Taylor and colleagues argues that people living in sub-Saharan Africa are underrepresented and their ethnicity often misrepresented in the global population of study participants for clinical trials for vaccines Read now: https://bit.ly/4iGU1Nr

How does household size play a role in the association between multimorbidity and health and social care outcomes in older adults? Read this new study by Clare MacRae and colleagues to find out: https://bit.ly/4apIxf6

What’s been happening to hypertension prevalence and control in England over the last 20 years? A study from researchers @qmul.bsky.social, recently published in BMJ Medicine, has mixed news. 🧵

How have hypertension trends changed over the last two decades? Catherine Graham and colleagues determine annual trends in hypertension diagnosis, true hypertension prevalence, and control and use of antihypertensive drugs in England. https://bit.ly/4oCb0SE

🔥 The #ClimateEmergency is a health emergency too. We're calling for your #research and #editorials exploring the climate–health connection. Hear more from our EiC and get involved by browsing our latest articles https://bit.ly/48Zzuki

@bmj.com & @bmjmedicine.bsky.social -

Ever wondered what it’s like to work on a medical journal? Our EiC, Sophie Cook, shares how she got started in publishing. #Publishing #EditorialRoles #CareerInPublishing

Is the evidence there for whole genome sequencing screening for newborns? Karoline Freeman and colleagues examine the challenges with current evidence synthesis and provide a roadmap for future evidence generation. https://bit.ly/47ZFUPQ

A new linked editorial by Ethan Nella and Jennifer Couturier reflects on the cohort study by Catharine Morgan and colleagues, highlighting the importance of recognising and managing risks in patients diagnosed with eating disorders https://bit.ly/4oZnwwA

How do eating disorders affect health outcomes in patients? Catharine Morgan and colleagues examine the short and long term adverse physical and mental health outcomes, all cause mortality, and deaths in individuals with a diagnosis of an eating disorder https://bit.ly/3KdOwck

From Trials and Cohort Studies to Methods Primers & Specialist Reviews, our content spans a wide range of articles. If your work impacts practice & enhances patient care, it may find a home with us. Learn more on our author pages #submissions https://bit.ly/4qiiGeX

Antimuscarinic bladder drugs are often avoided in older people due to concerns about effects on cognitive decline and dementia. A study published in January in BMJ Medicine challenged findings from previous observational studies on this association.🧵

New research by Corita Grudzen and colleagues finds no clear evidence that nurse led telephonic palliative care improved quality of life, or any secondary outcomes, relative to specialty outpatient palliative care. Read the full paper here: https://bit.ly/3Xrms8l

Corita Grudzen and colleagues compare the effectiveness of nurse led telephonic palliative care with specialty outpatient palliative care on quality of life, symptom burden, loneliness, and healthcare use, after attending the emergency department. https://bit.ly/3Xrms8l

🔍 We can’t afford to overlook the crucial issue of Content Integrity. BMJ Medicine upholds ethical standards and assesses content—especially in the era of #AItools. Find out more about content integrity at BMJ https://bit.ly/4q1igJu

The annual ‘winter pressures’ season is upon us. A year ago a cohort study in BMJ Medicine highlighted the role of multimorbidity on winter hospital admissions. Let’s take a look. 🧵

Did you know we publish material from Clinical Trials and Systematic Reviews to Methods Primers and Specialist Reviews? If your research improves patient care, we want to hear from you. Visit our author pages to get started: https://bit.ly/4qiiGeX

One of the first studies published in BMJ Medicine examined the safety of ezetimibe in lipid-lowering treatment. Ezetimibe prescribing has increased since this paper was published in 2022, following updated NICE lipid modification guidelines in 2023. So, what did the study by Wang el al. find? 🧵

In a new Methods Primer @danlewer.bsky.social and colleagues explain why when studying risk factors for health outcomes, looking at results that are statistically significant after mutual adjustment in a multivariable regression model can lead us astray. https://bit.ly/3JzNTJI

We wrote an article explaining why you shouldn't put several variables into a regression model and report which are statistically significant - even as exploratory research. bmjmedicine.bmj.com/content/4/1/.... How did we do?

🌍 How does climate affect health? We’d love to see your #research and #editorials on this crucial topic. Our Editor-in-chief shares insights on the #ClimateEmergency—join the conversation, see our latest climate research articles https://bit.ly/48Zzuki

Check out our starter pack: go.bsky.app/UzGUsD2 #MedSky #BMJMedicine#TheBMJ

Ever wondered what it’s like to work on a medical journal? Our EiC, Sophie Cook, shares how she got started in publishing. #Publishing #EditorialRoles #CareerInPublishing

Whether it’s original research, a cohort study or methods primer, we welcome submissions that influence practice and benefit patients. Check out our author pages for more information https://bit.ly/4qiiGeX

Iiris Juulia Turunen and colleagues compare routine high risk human papillomavirus (hrHPV) screening with cytological screening in this new study on cervical cancer screening. https://bit.ly/4nTujqI

Victor Sartorius and colleagues investigate inequalities in neonatal mortality, finding a strong link between a mother's residential socioeconomic level and neonatal mortality in France. Read the full study now: https://bit.ly/46t4UNk

This study by Jennifer Hirst and colleagues highlights a critical need for further exploration into the inequalities in HRT prescribing across England. https://bit.ly/3KpaeKg #HealthDisparities #SDOH

Live webinar: Hear from experts, including two authors of a new BMJ Oncology paper that assesses the contribution of germline and somatic gene variants to prostate cancer. 📅 1 Oct, 12pm BST | Register here: https://bit.ly/4n0TTsZ #ProstateCancer #BMJMedicine

Research by Jennifer Hirst and colleagues reveal disparities in HRT prescribing across England. Differences were identified based on ethnic group, socioeconomic status, and geographical location. This highlights critical areas for improving equitable access to care. https://bit.ly/3KpaeKg

Join us as we uncover critical insights into health equity as Victor Sartorius and colleagues investigate inequalities in neonatal mortality, finding a strong link between a mother's residential socioeconomic level and neonatal mortality in France. Read the full study now: https://bit.ly/46t4UNk

How do I conduct a high quality case study? Find a step-by-step guide below! 🧵

In this linked editorial, Penelope Hawe reflects on Trisha Greenhalgh's RMR article and the importance of design decisions in case studies https://bit.ly/48yCBzy

Many observational studies use regression adjustment to deal with confounding bias. A methods primer in BMJ Medicine by Frederick Ho explains the basic principles, including why researchers must choose their confounders carefully 🧵

Calling all researchers and educators📣 This new RMR by @trishgreenhalgh.bsky.social on how to conduct effective case studies, offers guidance for using them for learning & decision-making. Essential reading for robust research! https://bit.ly/47PL01l

Hear from experts, including the author of a new BMJ Mental Health paper, on the risk of first onset psychosis or mania requiring hospitalisation in adults diagnosed with ADHD after starting ADHD medication. 📅 24 Sep, 12pm BST | Register here: https://bit.ly/4myGUye

Our latest Methods Primer by Frederick Ho breaks down the core principles of regression adjustment for causal inference. Learn when to adjust for a covariate and when not to, to get clearer insights! https://bit.ly/3VqpuZB

From public health crises to evaluating interventions, case studies offer invaluable insights into real-world phenomena. But how do we ensure quality & consistency? This new paper by @trishgreenhalgh.bsky.social explores issues in case study research. https://bit.ly/47PL01l

How effective are de-implementation strategies to reduce low value care? Aleksi Raudasoja and colleagues conducted a systematic review and meta analysis to find out. 🧵

How deeply do socioeconomic factors impact the start of life? New research by Victor Sartorius and colleagues sheds light on the magnitude and evolution of inequalities in neonatal mortality rates in France. Read the full study now: https://bit.ly/46t4UNk #Healthdisparities

Teen fitness ➡️ late-adult diabetes risk? Marcel Ballin and colleagues assess the association between adolescent cardiorespiratory fitness and risk of type 2 diabetes in late adulthood in their latest research. Read now: https://bit.ly/4m5BXxs

Why are some asthma patients readmitted more often? Research from Alexander Adamson and colleagues reveals that components of the adult asthma discharge bundle were associated with reduced readmission to hospital for asthma. Read the full Research article here: https://bit.ly/4lncI8A

A new systematic review by Aleksi Raudasoja and colleagues assesses the effectiveness of various de-implementation interventions in primary care, targeting care that provides limited or no value for patients. Read here now: https://bit.ly/460RRnl