Yan Xie and colleagues assess whether initiation of GLP-1 receptor agonists rather than sulfonylureas is associated with all cause acute pancreatitis and cause specific acute pancreatitis in this nationwide cohort. https://bit.ly/4eQZbGG

Explore our Methods Primers Collection, where all resources in this area are conveniently organized for your reference https://bit.ly/45vZb9G

A new review by Amira Mahmood and colleagues summarises the latest consolidated WHO treatment guidelines for pulmonary tuberculosis including evidence to support agents and regimens, and emerging therapies. Read the full review in BMJ Medicine: https://bit.ly/4ugPFl0

Is there association between fragility fracture and interruption of bisphosphonate prescription? New research by Georgina Nakafero and colleagues examines incidence of fragility fracture, atypical femoral fracture & osteonecrosis of the jaw after bisphosphonate prescription. https://bit.ly/4eLCR1f

Vaccine cold chains are vital but prone to weaknesses that are particularly acute in sub-Saharan Africa. Gilbert Rukundo and colleagues examine how new advances and challenges in vaccine cold chains will affect readiness to control vaccine preventable disease LMICs in Africa https://bit.ly/4ckcvlw

Metabolic dysfunction associated steatotic liver disease (MASLD) is the new name for non-alcoholic fatty liver disease (NAFLD). A new specialist review in BMJ Medicine offers a guide to assessment of MASLD and discusses approved and emerging treatment options for MASLD. 🧵

Take a look at our open access specialist reviews, in one handy Collection for you to browse anytime https://bit.ly/3YpbpgB

Gilbert Rukundo and colleagues examine the vaccine cold chain in African low and middle income countries, and how new and emerging advances and challenges will affect readiness to control the burden of vaccine preventable disease on the continent https://bit.ly/3Q6TWbO

A new systematic review by @kdsweeney.bsky.social and colleagues identifies primary care and community based interventions for patients with multimorbidity involving depression or anxiety, to determine their effectiveness for improving patients’ health https://bit.ly/3Om7OhG

Yan Xie and colleagues examine glucagon-like peptide 1 receptor agonist discontinuation and risks of major adverse cardiovascular events in adults with type 2 diabetes https://bit.ly/4cyz4CY #CardiovascularHealth

Alan Wright and colleagues find that that lowering blood pressure early in pregnancy may reduce pre-eclampsia risk by up to 50%, but a large trial is needed to confirm the benefits, risks, and costs of this for clinical practice. https://bit.ly/4srHBfI #MaternalHealth

Tina Reinson and colleagues summarise current understandings in the pathogenesis, diagnosis, and management of metabolic dysfunction associated steatotic liver disease in adults in a new review. https://bit.ly/41HJJVA

A new study by Alan Wright and colleagues finds lowering blood pressure from early pregnancy may reduce preterm and term pre-eclampsia Read the full study in BMJ Medicine: https://bit.ly/4sfwDdh

New research by Yan Xie and colleagues found cardiovascular benefit of GLP-1RAs accumulated with continuous use, but even brief periods of discontinuations could progressively erode and ultimately reverse protection. Read the full paper in BMJ Medicine: https://bit.ly/3PpsINi

Jonathan Batty, Tamara del Toro, and Marlous Hall reflect on the results and potential limitations in Yan Xie and colleagues' research paper on the use of GLP-1 receptor agonists and their effectiveness in reducing major adverse cardiovascular events https://bit.ly/3NzRbio

Take a look at our open access specialist reviews, in one handy Collection for you to browse anytime https://bit.ly/3YpbpgB

Yan Xie and colleagues characterise patterns of use of glucagon-like peptide 1 receptor agonists and assess the associations between treatment scenarios and the risk of major adverse cardiovascular events in adults with type 2 diabetes https://bit.ly/4bIqT5m

Research by Kayleigh Mason and colleagues examines trends in the use of advice and guidance versus direct referral in NHS primary care from 2015 to 2023, raising questions about efficiency and equity in referral pathways. #HealthEquity https://bit.ly/4rSozPx

Interested in non-pharmacological interventions for fatigue in long term conditions? Joanna Leaviss and colleagues find interventions that support individuals to increase physical activity or that are based on cognitive behavioural approaches are effective in reducing fatigue https://bit.ly/47LPFAi

Immortal time bias in observational studies is common. A new BMJ Methods Primer from Harrison Hansford et al. explains what it is, and how to avoid it. 🧵https://bmjmedicine.bmj.com/content/5/1/e001280

In their new study, Joanna Leaviss and colleagues find that interventions focusing on physical activity and cognitive-behavioural approaches are effective in reducing fatigue in people with long-term medical conditions. Read the full study here: https://bit.ly/3PerFQ4

As eosinophilic oesophagitis prevalence continues to rise globally, Mark Mahon and colleagues explore recent advances in targeted treatments and diagnostics which are redefining long term care. https://bit.ly/4s4OBQk

A new review by Mark Mahon and colleagues explores developments in the diagnosis and management of eosinophilic oesophagitis, highlighting promising emerging minimally invasive tests for patients. Read the full article here: https://bit.ly/3P7Dt6A

Sara Pretorius and colleagues review UK guidelines for individual health conditions and propose improvements to guideline development processes to improve usability of guidelines for clinicians managing patients with multiple long term conditions https://bit.ly/4slFri8

Estimates of multimorbidity range from 15-43% of the adult population, and most people with one long term condition have more than one. How well do guidelines account for this? How often do they offer specific guidance on how to manage long term conditions that may be affected by comorbidities?🧵

Barbara Nicholl and colleagues reflect on how clinical guidelines largely focus on single diseases and are inadequate for the care required by people with multiple long-term conditions Read the full Editorial in BMJ Medicine: https://bit.ly/4tWorAy

How did you get on with our stats question? Was it too mean? Here are the answers🧵

In this study Sara Pretorius and colleagues evaluate how UK guidelines for individual health conditions account for coexisting conditions and propose changes to guideline development to improve care for people with multiple long term conditions https://bit.ly/4sczrYK

Explore our Methods Primers Collection, where all resources in this area are conveniently organized for your reference https://bit.ly/45vZb9G

Fancy a stats quiz? Read through the example and answer the questions in the thread below 🧵

New research📢 Geertruida Bekkering and colleagues compare the effectiveness and safety of pharmacological and non-pharmacological smoking cessation interventions in people with severe mental illness. https://bit.ly/4kHE8Ye

A new Methods Primer by Dan Green and colleagues outlines circumstances where the mean and standard deviation alone are insufficient summary variables, and provides a simple appraisal method for reviewers without raw data Read in BMJ Medicine now: https://bit.ly/4bJz3w8

Walker and Lee reflect on a study by Faye Cleary and colleagues that presents a new kidney failure risk equation that doesn't need albuminuria testing, saying it has potential to improve health equity but albuminuria testing is important beyond predicting kidney failure https://bit.ly/4bJz3w8

A new study from Faye Cleary and colleagues presents a new risk prediction equation for kidney failure in patients with chronic kidney disease who do not require data for the urine albumin to creatinine ratio Read the full study here: https://bit.ly/4qtOpsr

Take a look at our open access specialist reviews, in one handy Collection for you to browse anytime https://bit.ly/3YpbpgB

Yuanyuan Zhang and colleagues compare the efficacy and safety of different intensive systolic blood pressure targets versus usual care on cardiovascular and renal outcomes in high risk patients https://bmjmedicine.bmj.com/content/5/1/e001791

In this new study, Yu-En Chen and colleagues found that time restricted eating overall improved metabolic health outcomes compared with usual diets, and early time restricted eating was superior to late time restricted eating. Read the full study here: https://bit.ly/4jY06FV

New Year, New you. If your resolution involves hitting the gym, you're on the right track! Han Han and colleagues' findings support the notion that habitual engagement in a diverse range of physical activities is associated with lower mortality. https://bit.ly/4jSKy6v

What are the optimal types of time restricted eating? Yu-En Chen and colleagues evaluate the effect of overall time restricted eating on metabolic health outcomes in their new study. https://bit.ly/4jY06FV

A new study by Edmund Lamb and colleagues dives into two sets of estimating equations, using single and combined creatinine/cystatin C biomarkers to assess their accuracy in patients with moderate chronic kidney disease. https://bit.ly/4jSWhBP #CKD #MedicalResearch

Does your workout variety matter for long-term health? New research from Han Han and colleagues examines the associations of long term engagement in individual physical activities and physical activity variety with the risk of death. https://bit.ly/4jSKy6v

Explore our Methods Primers Collection, where all resources in this area are conveniently organized for your reference https://bit.ly/45vZb9G

Huseyin Naci and colleagues assess survival gains and additional Medicare spending associated with early access to new cancer drugs through the US FDA's accelerated approval pathway, examining the benefits and costs of earlier access. https://bit.ly/4jtsqQt

Are you conducting a case study in 2026? Here are some tips from @trishgreenhalgh.bsky.social's guide to case studies, published in BMJ Medicine. 🧵

New research by Huseyin Naci and colleagues weighs up the cost and benefit of early access to new cancer drugs through the US FDA’s accelerated approval pathway, compared to access to cancer drugs following completion of confirmatory trials https://bit.ly/4q374f1

🔥 The #ClimateEmergency is a health emergency too. We're calling for your #research and #editorials exploring the climate–health connection. Hear more from our EiC and get involved by browsing our latest articles https://bit.ly/48Zzuki

In this study, Rose Higgins and colleagues look at opioid prescribing in patients on orthopaedic waiting lists during the pandemic to understand the impact of longer elective wait times. https://bmjmedicine.bmj.com/content/4/1/e001743

The COVID-19 vaccine trials were fast, but highlighted a critical gap in health equity. Alice Taylor and colleagues argue that people living in sub-Saharan Africa are underrepresented in the global population of study participants for clinical trials. https://bit.ly/4iGU1Nr

🔍 We can’t afford to overlook the crucial issue of Content Integrity. BMJ Medicine upholds ethical standards and assesses content—especially in the era of #AItools. Find out more about content integrity at BMJ https://bit.ly/4q1igJu

A new study by Rose Higgins and colleagues quantifies changes in opioid prescribing in people on orthopaedic waiting lists to understand the impact of longer elective wait times during the covid-19 pandemic. https://bit.ly/3YjUHyX #Opioids #Covid19