New study shows 17β-estradiol induces NOS-dependent vasorelaxation in mouse aorta, with subtle sex- differences among ER subtypes. PI3K inhibition enhances relaxation by reducing MLC phosphorylation. doi.org/10.1016/j.vp...

Does vessel size truly dictate soluble guanylate cyclase sensitivity? A new commentary on Lubomirov et al. suggests enhanced cinaciguat responses in smaller arteries may reflect hypoxia–reoxygenation and pathological context, not intrinsic diameter effects. #vascularbiology #NOcGMP #sGC

New study: Reduced LMOD1 promotes smooth muscle cell proliferation and vascular lesion growth via CDK6 activation. Targeting CDK6 restores normal proliferation, revealing a reversible pathway in vascular remodeling. doi.org/10.1016/j.vp...

🚨New review explores how organ-on-chip especially endothelium-on-chip technology helps to unravel disease mechanisms tied to endothelial dysfunction. A game-changer for disease modeling, early detection & drug discovery. #OrganOnChip #VascularBiology #Endothelium doi.org/10.1016/j.vp...

🚨New publication alert: GDF15 alleviates diabetic endothelial dysfunction & oxidative stress through AMPK-dependent pathways. A promising therapeutic target for vascular protection in diabetes doi.org/10.1016/j.vp... #GDF15 #Diabetes #EndothelialHealth #OxidativeStress #AMPK

🚨New review explores how organ-on-chip especially endothelium-on-chip technology helps to unravel disease mechanisms tied to endothelial dysfunction. A game-changer for disease modeling, early detection & drug discovery. #OrganOnChip #VascularBiology #Endothelium doi.org/10.1016/j.vp...

A systematic meta-analysis evaluates lorundrostat, a novel aldosterone synthase inhibitor, in patients with uncontrolled hypertension. The analysis suggests potential blood pressure–lowering effects, though further large-scale trials are needed to confirm long-term efficacy and safety #Hypertension

Our new review explores how targeting hypothalamic signaling may transform obesity care. GLP-1R agonists & next-gen peptides, such as AMG 133, show enhanced weight loss & metabolic effects. doi.org/10.1016/j.vp...

New review highlights the Apelin/APJ pathway as a promising target in glioblastoma. By driving tumor angiogenesis, growth, and therapy resistance, Apelin could hold the key to more effective GBM treatments doi.org/10.1016/j.vp... #Glioblastoma #CancerResearch #NeuroOncology #Apelin #Angiogenesis

Atherosclerosis isn’t just about LDL, it’s also about leaky arteries. Our latest review explores emerging therapies that target transendothelial permeability, a promising, underexplored frontier in atherosclerosis. doi.org/10.1016/j.vp...

🎉Vascular Pharmacology Young Researcher Award 2025! Support emerging scientists—apply or nominate today! #VascularResearch #YoungScientists More detials: www.sciencedirect.com/journal/vasc...

HOT OFF THE PRESS: CXCR4, a GPCR best known for roles in neuronal migration, is now observed on ependymal motile cilia. This is the first report linking CXCR4 to motile cilia in ependymal cells. Find out more at doi.org/10.1016/j.vp...

New review highlights how perivascular progenitor cells act as reservoirs of mesenchymal stem cells, driving tissue repair, fibrosis, and regeneration—unlocking new paths for cell therapy, tissue engineering, and disease prediction #stemcells #tissueengineering #regenerativetherapy #vascularfibrosis

New study deciphers the genetics of chronic venous disease (CVD) using multi-omics! GWAS + eQTL + endothelial assays reveal key QTLs (VSTM2L, RPRD1B, SAMHD1, PNMA2) shaping vascular function & a diagnostic model with AUC = 0.898. A step toward precision biomarkers for CVD #Genomics #VascularBiology

New insights show how Drp1, a master regulator of mitochondrial fission, is controlled by multiple post-translational modifications. Targeting Drp1 may open promising therapeutic paths for restoring mitochondrial dynamics and protecting the heart. www.sciencedirect.com/science/arti...

Publication alert 🚨 New study shows Sodium-glucose cotransporter 2 inhibition by canagliflozin boosts testicular microvascular function & vascular signaling in a swine model of metabolic syndrome & ischemic cardiomyopathy. Highlights vasoprotective effects beyond the heart. #MicrovascularHealth

New insights on CTD-associated pulmonary arterial hypertension (CTD-PAH): an immune-driven, more aggressive form of PAH with worse survival than idiopathic PAH. Early combo therapy, close monitoring, and drugs like macitentan & selexipag show promise. #PAH #CTD #PulmonaryHypertension

New review highlights challenges in modeling doxorubicin (DOX)-induced cardiotoxicity across animal models. Acute vs chronic models, species differences, and missing comorbidities limit translation to humans. Key for advancing personalized cardio-oncology therapies. #Cardiotoxicity #CardioOncology

📢 Call for papers! Special issue: Gene/Genome Editing in Cardiovascular Biology and Disease Guest Editor: Joseph Miano, PhD 📆Deadline: 25 July 2026 ❓Who is it for: Studies or reviews involving gene/genome editing in the cardiovascular system using cells, organoids, and animal models.

single-cell RNA-seq reveals a shift toward pro-inflammatory M1 macrophages in abdominal aortic aneurysm (AAA), driven by STAT1 signaling. 10-gene inflammatory signature were developed that predicts prognosis & highlights potential therapeutic targets for AAA. www.sciencedirect.com/science/arti...

Explore the cutting-edge of vascular disease research! This special issue calls for papers on germline and somatic genomic and epigenomic alterations shaping vascular pathology. Submit insights on inherited and acquired changes driving diagnosis, therapy, and personalized medicine #VascularGenomics

📢 Call for Papers! Vascular Pharmacology special issue: Stem Cell & Organoids in Vascular Research Guest Editors: Kai Wang, Yifei Miao 📅 Deadline: 15 May 2026 www.sciencedirect.com/special-issu...

Blocking C3aR cuts oxidative stress & MMP-2 activity in aortas of Ang II–treated hypertensive mice, without lowering BP. Highlights complement’s role in vascular damage, a potential new target in hypertension. Link: www.sciencedirect.com/science/arti...

Unlock the future of heart health! The XXIV SIRC Congress spotlights new frontiers: immunoinflammation, mitochondrial dynamics, epigenetics, and COVID-19’s impact—driving more personalized, preventive cardiovascular care. #CardioFrontiers #HeartResearch #Aging #Innovation Author @enzolio.bsky.social

Vascular Pharmacology is a journal of Vascular Biology and Medicine. We're excited to connect with our community and share the latest updates, published articles, and upcoming activities. Thank you for being part of our journey!👍🌹