📋 New on The Point of Care Medicine Substack Rapid-Fire Pearls from January 2026 - 23 quick, high-yield takeaways: • CPPD mimicking sepsis • Richter’s Transformation • Cardiac amyloidosis patterns • Anti-NMDA encephalitis • Rhabdomyolysis lab findings …and more Read it here 👇

📝New on The Point of Care Medicine Substack In-depth breakdowns of the best clinical cases from January 2026, sourced from the NEJM and CPS: • Lyme Neuroborreliosis + Babesiosis co-infection • Bálint’s Syndrome • Autoimmune Nodopathy • Takayasu’s Arteritis • Wilson’s Disease Summaries + pearls 👇

In case you missed it! Check out our recaps of the best clinical cases from October and November 2025! Loaded with interesting diagnoses and pearls! These were easily our most viewed/liked posts in recent months. Links below!

New episode! Why do lactulose and rifaximin specifically help to treat hepatic encephalopathy? Links to the episode and Substack post below!

Most recent Substack post dropped! Features IBD, GERD vs NERD, COPD, OA, Hepatorenal Syndrome, Invasive Fungal Infections, and Bicarbonate! rokeefemd.substack.com/p/im-and-ho...

Read the most recent Point of Care Medicine Substack post! You can also view it on the POCM website. www.pointofcaremedicine.com/blog-post/i... Subscribe to the Substack rokeefemd.substack.com/ x.com/ROKeefeMD/s...

Why is opioid withdrawal not deadly? Withdrawal presents with symptoms opposite of opioid intoxication - dilated pupils, diarrhea, nausea, restlessness, piloerection, anxiety, yawning, and sweating.

Dicyclomine provides targeted relief of GI symptoms during opioid withdrawal via dual action of anticholinergic effects and direct smooth muscle relaxation. By blocking muscarinic receptors, is decreases smooth muscle tone, GI secretions, and GI motility.

New episode! Opioid Withdrawal - Quick Admit! A comprehensive guide on how to complete a thorough history and physical (H+P) for patients presenting to the hospital with opioid withdrawal! open.spotify.com/episode/4zW...

6 Facts Every Clinician Needs to Know About Tumor Lysis Syndrome (2025)

12 Key Principles for Diagnosing and Managing Vertigo and Dizziness 🧵

CKD & Atrial Fibrillation: Navigating the Anticoagulation Maze 🧵

10 Key Facts About Ablation for Atrial Fibrillation 🧵 #POCM #MedEd #Cardiology #MedThreads

📄 A full guide to admitting a patient with AFib with RVR Includes an admission checklist, HPI intake, focused exam, etiology/ddx, and a detailed vs limited EHR dotphrase. 🧵

20 Atrial Fibrillation Facts Every Physician Needs to Known 🧵

Atrial Fibrillation in 100 Seconds

Why are ST-elevation (STE) cutoffs different for leads V2-V3, and specifically higher for younger men? #ECG #Cardiology #STEMI #MedEd #ClinicalPearls #Diagnosis #EmergencyMedicine

Why does ACS cause pain radiating to the arms? #ACS #Cardiology #MedEd #ClinicalPearls #Diagnosis 1. Shared Pathways Cardiac nociceptive input travels via visceral afferents, converging in the spinal cord primarily at C5-T1 dermatomes. This is the same segmental innervation as the brachial plexus

Why does sitting up and leaning forward improve pain in pericarditis? - Lying flat increases pressure on the posterior pericardium as the heart rests more heavily on it. - In an upright position, the heart drops anteriorly and inferiorly, relieving pressure on the posterior pericardium

8 Facts to Help Master the Interpretation of Liver Chemistry Tests Elevated liver tests? Don't panic! This thread will give you a structured approach to interpreting LFTs, differentiating patterns of injury, and knowing when to worry. - Thread 🧵 #MedEd #GI #POCM

14 Must-Know Facts for Managing Pulmonary Embolism in 2025 PE is the 3rd leading cause of CV death. This thread breaks down essential PE management for hospitalists: risk stratification, diagnostics, & treatment. - Thread 🧵