Alexander Howard (@alexanderhoward.bsky.social)

I'm very excited to share my first graduate research project! Check out our preprint which describes how data generated with directed evolution can be used to model the phenotypic effects of naturally-evolved sequence variants. (1/11) www.biorxiv.org/content/10.1...

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Combining Directed Evolution with Machine Learning Enables Accurate Genotype-to-Phenotype Predictions Linking sequence variation to phenotypic effects is critical for efficient exploitation of large genomic datasets. Here we present a novel approach combining directed evolution with protein language m... https://www.biorxiv.org/content/10.1101/2025.01.27.635131v1