Wearn Xin (Edeline) (@wearnxin.bsky.social)

We've identified a group of nucleases that can target multiple phages with hypermodified DNA, using a sensor domain present across many domains of life. We’ve even used this as a tool to find phages with hypermodified DNA! Really thankful to all the co-authors who have been such great help!

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END nucleases: Antiphage defense systems targeting multiple hypermodified phage genomes Prokaryotes carry clusters of phage defense systems in defense islands that have been extensively exploited bioinformatically and experimentally for discovery of immune functions. However, little effo... https://www.biorxiv.org/content/10.1101/2025.03.31.646159v1