Although deep brain stimulation for common movement disorders reliably improves motor symptoms, a new meta-analysis found that routine STN-DBS for PD resulted in significantly poorer speech intelligibility compared with medical therapy. https://loom.ly/-Fhesto

Excellent viewpoint article on mitochondrial Parkinson's disease by Percetti and colleagues. https://loom.ly/sj3wYNs

A key study by Andriolli and colleagues explores how D2 receptor activity within the indirect pathway contributes to the development of levodopa-induced dyskinesia and D2-agonist associated dystonia. https://loom.ly/TMnI4Co

An international panel of neurologists, physiatrists, PTs, and clinimetricians found 10-Meter Walk Test and Modified Frenchay Scale to be useful first steps for evaluating lower and upper limb function, respectively, in patients with spastic paresis. https://loom.ly/Q58nang

A study demonstrated that PD and MSA have distinct glymphatic free-water pathological profiles. An integrated model incorporating neuroimaging and clinical metrics showed excellent ability to differentiate PD from MSA, with an area under the curve of 0.994. https://loom.ly/vhmVFdY

Recognizing which genetic dystonias are responsive to DBS is essential. In Woodhouse–Sakati syndrome, Alhodaif et al. evaluated five patients and reported an approximate 39% improvement in BFMDRS scores following bilateral GPi DBS. https://loom.ly/VLcx-VQ

Many movement disorder rating scales in MDS’s portfolio are now digitalized in REDCap. These e-versions were developed through a structured, iterative process to ensure accuracy and quality. https://loom.ly/VCqfAj8

A must-read (and watch) article by Bernardi and colleagues exploring the spectrum of ATP1A3-related movement disorders. The inclusion of a large number of outstanding videos makes it a true visual atlas of these conditions. https://loom.ly/6mLoFOA

Changes in evidence standards call for more rigorous and modern clinical trials. Find out what that means for the latest assessment in medical treatments for ET. https://loom.ly/7b3mW9w

A fitting tribute to Dr. Mark Hallett (1943–2025), one of the true giants in movement disorders and functional neurological disorder. This article introduces the proposed “Hallett sign”. https://loom.ly/u83Gj-4

This important imaging study in Huntington’s disease (HD) reports significant subcortical iron accumulation and noradrenergic neuronal loss. A question for the future: What is the role of noradrenergic pathology in HD? https://loom.ly/dE06Y2Y

An important case illustrating that REM sleep behavior disorder (RBD) does not necessarily signify an underlying alpha-synucleinopathy. Instead, it may arise from pathology involving the amygdala, with the clinical threshold potentially lowered by antidepressant use. https://loom.ly/E56j5nw

A strength of the 2016 nomenclature proposal for genetically determined movement disorders is the delivery of relevant information by linking phenotype-genotype. However, with this comes possible subjectivity. Read more on the strengths and weaknesses. https://loom.ly/TV7jCRE

This phenotypic heatmap of individuals diagnosed with NKX2-1-related disorders reports the presence of neurodevelopmental delay and chorea in 94% and 92% of cases, respectively. @movedisorder.bsky.social #PediatricSIG https://loom.ly/9xK-2Ys#PediatricSIG

More than 80% of MSA patients report pain, making it important to identify the type of pain. In this large study of 157 MSA patients, the authors explored pain subtypes. The two most common types were directly related to autonomic dysfunction. https://loom.ly/pq0N3Mw

This collaborative study (via DBSMatchMaker) demonstrates significant clinical improvement in patients with ADCY5-related disorder following bilateral GPi deep brain stimulation and represents the largest reported DBS case series in pediatric patients with this condition. https://loom.ly/JoHh2B8

Here is an excellent review article on the medical treatment of essential tremor by Dash and colleagues. https://loom.ly/7b3mW9w

Here is a large Dutch cohort study by Prooije and colleagues on SCA27B: https://loom.ly/JJFljvI Key takeaways: 1) Core features appear with GAA 200–249 expansions; 2) episodic SCA27B can mimic stroke 3) ~50% show benefit from 4-aminopyridine.

An outstanding review, along with related correspondence, that emphasizes the “second-hit hypothesis” in peripherally induced movement disorders. https://loom.ly/LFOXbng

Here is an insightful review by Lang and colleagues discussing LRRK2 as a potential disease-modifying target in sporadic Parkinson’s disease. https://loom.ly/41ob-eE

This study from Brazil found subclinical, predominantly restrictive respiratory dysfunction in Friedreich’s ataxia. Compared with controls, patients had lower O₂ saturation, FVC, and FEV₁. https://loom.ly/xomEySI

In this clinical trial (PREMANDYSK) by Rascol and colleagues, early addition of 200 mg/day of amantadine IR to levodopa in patients with early PD, before the onset of motor complications, reduced the incidence of levodopa-induced dyskinesia by an average of 50%. https://loom.ly/gIMI7X0

In this randomized, double-blind, placebo-controlled study, propranolol (titrated up to 240 mg/day) produced a significantly greater reduction in tremor than placebo in individuals with SCA12. https://loom.ly/zKIxli4

Is constipation in Parkinson’s disease associated with a higher burden of neuroinflammation? In this study, Camacho & colleagues found that early-stage PD patients with constipation showed markedly greater uptake of microglial activation markers across multiple brain regions. https://loom.ly/NxlNkpo

Digital health technology can measure symptom severity for gait, tremor, bradykinesia, etc. MDS's Technology Study Group systematically reviewed the application of these devices in clinical trials of levodopa, other PD drugs. https://loom.ly/Y3FT_9U

Kaplan–Meier analysis supported strong predictive value of a concise patient-reported MDS-UPDRS for dopaminergic initiation in early PD, underscoring patients’ central role in clinical decisions involving functional limitations. #COAProgram https://loom.ly/HFNAJUE

According to SynNeurGe criteria, the latest MDSGene literature review found that the PARK-RAB32 form of PD can be classified as S+ (evidence of synucleinopathy), N+ (neurodegeneration supported by imaging data), and GP+ (presence of a genetic variant). https://loom.ly/RWajhfA

Insightful article by Paparella and colleagues exploring the Bradykinesia complex (bradykinesia+ hypokinesia+ dysrhythmia+ sequence effect) in Parkinson's disease. https://loom.ly/FdlR_8g

Great study by Wilken et al. showing that basal ganglia theta activity correlates with the onset of dyskinesia — a finding that could shape future adaptive DBS approaches. https://loom.ly/CgFd3AE

Dystonia + ataxia with brain iron accumulation on imaging? Don’t forget to keep SCA50 in the differential. https://loom.ly/ETrE17Q

New population-based study from Sweden: Maternal TS/CTD is linked to higher risks of gestational diabetes and both elective & emergency C-sections, highlighting important pregnancy and neonatal outcome associations. https://loom.ly/o5oUT8w

An interesting study by Wang and colleagues concludes that PD and MSA-P have compromised AQP4 polarization, impairing glymphatic function, which is consistent with the known neuroimaging changes demonstrated by free-water imaging. https://loom.ly/xpqlC8s

In this interesting study, Kersebaum and colleagues provide electrophysiological evidence of impaired central pain modulation in PD patients. The key finding is a reduced habituation to repetitive noxious stimuli. https://loom.ly/kIDB6Io

Interesting study on the metabolomic profile of prodromal and clinical Parkinson's disease. Key observation: metabolites linked to smoking, caffeine intake, and acetaminophen use were consistently associated with lower PD risk. https://loom.ly/MsOGytI

In this report from Spain, GPi-DBS in 10 children/adolescents with SGCE-rlated Myoclonus Dystonia led to significant improvement in myoclonus (68.1%), generalized dystonia (63.2%), and dystonia during writing (48.1%), walking (70.3%) and running (44.2%). https://loom.ly/sDSWeng

Measuring fronto-striatal function to rate mild cognitive impairment versus dementia requires the right clinical outcome assessment. The #COA tests recommended by an MDS expert panel have psychometric qualities that enable improved PD diagnosis and research. https://loom.ly/vUxrUPM#COA

A major finding from Kishore et al.’s study of 7,918 PD patients in India: the average age at onset (~54 years) is significantly younger than that reported in Western populations. https://loom.ly/44XBdEo

Because the true carrier frequency of ataxia-causing genes and degree of reduced penetrance are likely underestimated by the current MDSGene dataset, improving access to genetic testing in underserved regions globally should be prioritized. https://loom.ly/kD79Fn4

How common are sleep disorders in patients with RFC1-spectrum disorders? In the following study, Funcis and colleagues highlight that they are exceedingly common, with obstructive sleep apnea (OSA) being the most frequent. https://loom.ly/zyeMJrc

Interesting work by Prof. Taira and colleagues: unilateral FUS pallidothalamic tractotomy (PTT) in Parkinson’s disease showed short-term improvement in bilateral wearing-off and dyskinesia. It is presumably due to bilateral projections of the PTT. https://loom.ly/blNUF0c

In this excellent review article, the authors highlight the distinct neuroanatomical and temporal dynamics of the non-motor aspects of PD and explore the possibility of developing adaptive DBS for non-motor symptoms. A "must-read" article for DBS-enthusiasts! https://loom.ly/FCX82rw

In this insightful viewpoint article, the authors discuss the impact of the recent FDA decision to end the requirement for blood monitoring in clozapine use. https://loom.ly/_HJvQNg

Exciting results from Yska et al.: Hematopoietic stem cell transplantation halted disease progression in CSF1R-related disorder after 6 months post-transplantation, with impressive clinical and radiological improvements at a median follow-up of 2.5 years. https://loom.ly/SE3UXUE

An important study by Wong et al. on neuro-ichthyosis linked to biallelic ELOVL1 variants. In this hypomyelinating leukodystrophy, commonly observed abnormal movements included spasticity, head tremor, and myoclonus. movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

"This intriguing study explores abnormalities in the central motor network among Parkinson’s disease patients with camptocormia. Key finding: In PD patients with camptocormia, there is heightened central muscle drive to the paravertebral lumbar muscles." https://loom.ly/HtBwgBs

Could altered D1/D3 receptor dynamics be driving RLS and its augmentation? Clemens et al. explore this compelling angle in a thought-provoking viewpoint article. A "must-read" piece for RLS-enthusiasts! https://loom.ly/NVkJgMo

Wrigley et al. report clinicopathologic insights into PSP and its mimics: 83.5% (197/241) of autopsy-confirmed PSP cases had the correct clinical diagnosis. Most common mimics? Lewy body diseases, CBD, and MSA. https://loom.ly/enEtKVQ

No significant benefit of transcutaneous tibial nerve stimulation (1 Hz via Geko device) for overactive bladder in Parkinson’s disease, per phase II STRIPE trial. Maybe 1 Hz isn’t the sweet spot, and it’s worth exploring other settings/devices! https://loom.ly/K7VqFd4

Does CBD have a prodromal phase? Still an open question, but a fascinating case by Tai et al. showed progressive, asymmetric parietal atrophy on serial MRIs spanning a decade before the clinical diagnosis was made! https://loom.ly/VbRDHrY