This Sunday I'll be participating in a livestream where I'll be discussing what I've built so far at @metasciencejournal.bsky.social. I'll also be discussing my website @gene-wizard.bsky.social where you can upload your genetics data and get detailed information on your SNPs & polygenic risk scores.

The White House is proposing massive cuts to NIH, NSF, and NASA. Meanwhile, they are wasting 2-3 billion A DAY in a misguided and completely counterproductive war in Iran, and asking to increase the already bloated DoD budget by $500 B. I've never been this mad at an administration in my life!

lol although it's pretty cool they're able to get internet access up there ..

"Grand Staircase doesn't lead to ballroom" ... lol who comes up with this stuff? Why build a staircase to nowhere?

I knew 2025 was a big year for AI, but I didn’t realize how big until I saw this graph. It was the year of the agentic AI revolution!

Have you heard of NIH virologist Chris Buck's discovery that a beer-based vaccine is effective against BK polyomavirus? Either way, check out my new Substack deep dive on the yeast-based vaccine revolution! Vaccines can be produced and consumed as foods! 🤯 => moreisdifferent.blog/p/yeast-base...

Read our first newsletter on Substack: metascienceobservatory.substack.com/p/metascienc... You can subscribe on Substack or on our conventional mailing list: metascienceobservatory.eo.page/kdntv

Moderna CEO: "we've told investors that we will no longer be running phase 3 trials (for vaccines). It's not possible to make a return on investment without access to the US Market" www.bloomberg.com/news/videos/... (quote from around 4:15 in the video)

Recent research adds to a growing body of work showing that #SARSCoV2 infection leads to long-term disruption of immune system function, potentially leaving people more vulnerable to future infections for years into the future. #COVID19 #LongCOVID www.sciencedirect.com/science/arti...

I am not a fan of Peter Diamandiss and Singularity University! Their “Abundance” conferences are scamy networking events for the ultra-rich. The conference appears increasingly out-of-touch in the light of the growing Abundance movement, which is actually focused on realizing abundance for all! 1/5

Amazing and eye-opening! Congrats @sholtodavid.bsky.social

PSA!! "In this summer program, high school students will explore careers in in medicine, biotech, health policy, and longevity." rootsofprogress.org/progress-in-...

PSA: on Nov 26th the White House's Office of Science & Technology policy released a Notice of Request for Information (RFI), the subject of which is "Accelerating the American Scientific Enterprise". Submit your cool ideas! Deadline to respond is Dec 26th www.federalregister.gov/documents/20...

Take a moment today to send letters to your congresspeople urging them support the National Institute for Healthy Longevity & Aging Research (NIHLAR) and the Advanced Approval Pathway for Longevity Medicines. Both advocated by The Alliance for Longevity Initiatives! actionnetwork.org/letters/driv...

Sign this petition to @mayorwu.boston.gov - Allow @waymo.bsky.social in #Boston!! Selfish unions are supporting a ban. Waymo cars are more climate friendly and safer! They also have the potential to reduce congestion dramatically. www.change.org/p/approve-th...

In certain fields, manuscript submissions are way up due to researchers using AI to help do data analysis and writing.

PSA: the next online Ekkolapto salon will feature a discussion with Jim O'Shaughnessy & Atman Pandya on new mechanisms for science funding. RSVP here to join the Zoom call: luma.com/oshaughnessy...

PSA for Boston-area folks - special event Monday Nov 10th on the future of AI and humanity. RSVP Here: www.aicamp.ai/event/eventd...

PSA: tomorrow afternoon (Oct 30th) ekkolapto is hosting an online (Zoom) Salon w/ Niko McCarty from AsimovPress, a one-of-a-kind magazine about scientific progress in biology. Should be really interesting and a great chance to ask Q's to Niko! RSVP here luma.com/asimovpress?...

Mind First Foundation Chief Scientist Preston Estep has published a review of "If Anyone Builds it Everyone Dies". A key point is that we need more rigorous scientific study of Steve Omohundro's emergent AI drives! Furthermore, AI scientists may help us craft safe AI. s-rsa.com/index.php/ag...

'Wrong to weigh in': GOP senator condemns FCC chair's 'absolutely inappropriate' move

Today, 9/21/2025, at 1 p.m. Pacific Time, the U.S. Transhumanist Party invites Professor Stefan Lorenz Sorgner to discuss Euro-Transhumanism, a vision that emphasizes a culturally nuanced, ethical, and inclusive approach to technological enhancement. www.youtube.com/watch?v=MJUA...

5,290 papers at #NeurIPS this year, out of ~23,000 submissions.

Trump is starting to ramp up an unprecedented assault on the First Amendment. Everyone should be paying attention to what's happening right now, and be ready to speak up for your rights!

An absurdly comprehensive treatment of the (relatively negligible) effects AI has on the environment.

Not a good look... 😬 (www.thefp.com/p/students-c...)

👇

Updated Novavax vaccine for #COVID dropping soon! ir.novavax.com/press-releas...

Great news today from Jim O'Neill, ChatGPT is available to all workers at HHS!

Great example of the Streisand effect 😆🤣

🤦‍♂️ And the worst part is all the taxpayer $ being wasted on a lot of these sites...

Bill and Liz have some great ideas on a new approval pathway at the FDA! You can join the YouTube livestream today (Sunday, August 17) from 4 - 6 pm ET and ask questions in the chat => www.youtube.com/watch?v=t9px...

PSA for Boston-area folks!! The 𝙷𝚞𝚖𝚊𝚗 𝙰𝚞𝚐𝚖𝚎𝚗𝚝𝚊𝚝𝚒𝚘𝚗 𝚂𝚞𝚖𝚖𝚒𝚝 will be held at the MIT Media Lab on August 23rd. Come see the products & projects that are pushing intelligence augmentation, bio-interfaces, longevity, consciousness, and more! I’ll be attending along w/ a bunch of @Ekkolapto folks!!

🚨🚨Parts of the Constitution were just casually deleted from Congress's official Constitution website. 😬 The parts deleted involve habeas corpus rights, forbidding titles of nobility, & forbidding foreign emoluments (salaries/gifts) for US officials. See for yourself: web.archive.org/web/diff/202...

Clearest evidence yet Trump is a wannabe dictator with no comprehension of or respect for the Constitution. Unfortunately, I suspect many ppl aren't aware of what's going on since people have been screaming "fascist!", etc for about nine years over every little thing, which causes ppl to tune out..

New on my Substack. If you find value in my posts, consider subscribing. You can also give a one-time donation here: coff.ee/moreisdiffer.... I am thinking of quitting my job to focus on writing full-time for a period. open.substack.com/pub/moreisdi...

Periodic reminder of this article by @jacobtref.bsky.social: blog.jacobtrefethen.com/10-technolog...

Meanwhile in the UK - government goons are bragging about how they are arresting people for non-violent, non-threatening speech. It's terrible what’s been happening in the land of John Stuart Mill.

Election denialism and tin foil hat conspiracy theories exist on the left too - this viral Substack post alleges that Elon Musk used Starlink to manipulate voting machines, LOL, together with Palantir. Also, Trip Lite UPS machines had "backdoors" and were network integrated with voting machines..

This story broke a month ago, but I just learned a few days ago and decided to write a post about it! moreisdifferent.blog/p/that-mit-p...

PSA - July 31st is the deadline for the Norm Handy Prize and Foresight Fellowship program at the Foresight Institute! foresight.org/norm-hardy-p... foresight.org/foresight-fe...

The amount of land the federal government owns is mind boggling. We should be selling small bits of land that have extremely high values for home building, like barren desert outside of Las Vegas (pictured below). Read Alex Tabarrok's latest : marginalrevolution.com/marginalrevo...

PSA: The American Science Acceleration Project has a request for information (RFI), and the deadline is tomorrow! Their goal is to make science 10x faster by 2030. This is admin is unusually friendly to metascience, so your comments could go a long way! www.rounds.senate.gov/imo/media/do...

Alex Kesin has presented a set of arguments for making statins available OTC Statins have been proven to be much safer than many of today's OTC drugs. Only 35% of ppl eligible under current guidelines are taking them. Alex estimates the cost per QALY is less than cost of a fast food combo meal 🤯🧵⬇️

wow, the Endnote plugin doesn't really work at all

I bet this tweet is why it's happening. Alcatraz was originally closed because it was three times more expensive to run.

Just published some thoughts on #LongCOVID research => moreisdifferent.blog/p/why-are-we...

Great quote

yikes Read economist Alex Tabarrok speaking out about these harmful layoffs at the FDA: marginalrevolution.com/marginalrevo...

I'm recovering from fatigue from flu (5 weeks ago) & a minor cold (3 days ago), and I'm tapering off wellbutrin. I've been noticing depressive thoughts. Interestingly, it seems like my perception of world is more accurate? I'm seeing a lot of flaws & limitations w people & things..#DepressiveRealism