Johne’s disease (JD), caused by Mycobacterium avium subspecies paratuberculosis (MAP), is a chronic infectious enteritis that threatens both domestic and wild ruminants, including the wood bison-a species of conservation concern in North America. onixonpoint.substack.com/p/diagnostic...

From malnutrition-related diabetes to genetic forms like MODY5 and the debated link between Alzheimer’s and insulin resistance, the diabetes landscape is broader and more complex than ever. onixonpoint.substack.com/p/type-5-dia...

This study aimed to investigate the biopathological characteristics of two distinct E. maxima isolates collected from geographically separated backyard poultry populations in Iran. onixonpoint.substack.com/p/intraspeci...

Inhibitory Effects of Manihot esculenta and Aloe barbadensis Leaf Extracts Against Poultry Eimeria Oocyst Sporulation: Alternatives to Antiprotozoal Resistance onixonpoint.substack.com/p/inhibitory...

Grip strength is associated with a range of health outcomes, from type 2 diabetes to depression. www.bbc.com/future/artic...

OniX OnPoint Animal Health Newsletter: Advances in Poultry Coccidiosis Control: Genetics, Vaccines, and Natural Alternatives Highlights from Recent Research on Immunization, Herbal Strategies, and Genetic Resistance in Poultry Health onixonpoint.substack.com/p/advances-i...

Human Monoclonal Antibodies: A Potential Countermeasure Against Clade 2.3.4.4b H5N1 Influenza Characterization of Broadly Neutralizing mAbs and Protection in a Murine Challenge Model onixonpoint.substack.com/p/human-mono...

Experimental H5N1 Infection in Dairy Cows: Clinical Outcomes and Viral Dynamics Replication of HPAI H5N1 Clade 2.3.4.4b Genotype B3.13 in Holstein Dairy Cattle Mimics Field Observations onixonpoint.substack.com/p/experiment...

Pre-existing Human T-Cell Immunity: A Key Defense Against H5N1 Influenza Conservation of Influenza T-Cell Epitopes Between Seasonal Strains and H5N1 Suggests Cross-Reactivity onixonpoint.substack.com/p/pre-existi...

Comparative Immunogenicity and Protection of H5N1 Vaccines in Geese Evaluation of Five Commercial Vaccines Against Highly Pathogenic Avian Influenza Virus H5N1 Clade 2.3.4.4b in Fattening Geese onixonpoint.substack.com/p/comparativ...

Human Monoclonal Antibodies: A Powerful Strategy Against H5N1 Influenza Rapid Generation and Therapeutic Efficacy of mAbs from Convalescent Patients in a Murine Model onixonpoint.substack.com/p/human-mono...

Recombinant H5N6 Avian Influenza: Enhanced Pathogenicity and Transmissibility Through H9N2 Internal Genes H5N6 viruses with H9N2-derived internal genes exhibit increased pathogenicity and aerosol transmissibility, posing a greater threat to human health. onixonpoint.substack.com/p/recombinan...

Bispecific PD-1/VEGF Inhibitors: The Next Leap in Cancer Immunotherapy Clinical Momentum and Scientific Validation for Dual Checkpoint and Angiogenesis Blockade onixonpoint.substack.com/p/bispecific...

OniX OnPoint Animal Health Newsletter: Navigating Avian Influenza: Vaccine Responses, Viral Evolution, and Transmission Risks in Poultry and Dairy Cattle Latest Research on Avian Influenza Vaccines, Immunity, and Transmission in Poultry and Livestock onixonpoint.substack.com/p/onix-onpoi...

Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice-An unbiased functional study onixonpoint.substack.com/p/multiple-s...

Targeted Restriction of Isoleucine and Valine, but Not Leucine, Promotes Metabolic Health and Offers New Strategies for Obesity and Diabetes Prevention onixonpoint.substack.com/p/distinct-r...

Antibody-Drug Conjugates (ADCs): Precision Powerhouses Transforming Cancer Therapy From concept to clinic—how ADCs are evolving to become smarter, safer, and more versatile weapons against cancer and beyond. onixonpoint.substack.com/p/antibody-d...

Evolutionary Lineage-Specific Genomic Imprinting at the ZNF791 Locus Discovery of Novel Imprinted Genes in Domesticated Animals onixonpoint.substack.com/p/evolutiona...

YL201: A Promising Antibody-Drug Conjugate for Advanced Solid Tumors Phase 1 Trial Demonstrates Encouraging Efficacy and Acceptable Safety Profile of a B7H3-Targeting ADC in Refractory Cancers onixonpoint.substack.com/p/yl201-a-pr...

YL201: A Promising Antibody-Drug Conjugate for Advanced Solid Tumors Phase 1 Trial Demonstrates Encouraging Efficacy and Acceptable Safety Profile of a B7H3-Targeting ADC in Refractory Cancers onixonpoint.substack.com/p/yl201-a-pr...

Getah Virus Identified in Wild Boar in China: A Novel Epidemiological Threat First Report and Genetic Characterization Reveals High Prevalence and GIII Subtype Identification in Wild Boar Population onixonpoint.substack.com/p/getah-viru...

PDCdb: the biological activity and pharmaceutical information of peptide-drug conjugate (PDC) PDCdb: the biological activity and pharmaceutical information of peptide-drug conjugate (PDC) onixonpoint.substack.com/p/pdcdb-the-...

Serum Albumin Drives Cross-Sensitization in Furry Animal Allergies A Component-Resolved Diagnostics Study Reveals the Molecular Basis for Cross-Reactivity Beyond Lipocalins onixonpoint.substack.com/p/serum-albu...

Enhancing the Bystander Effect of Antibody-Drug Conjugates by Using a Novel Caspase-3 Cleavable Peptide Linker to Overcome Tumor Heterogeneity onixonpoint.substack.com/p/enhancing-...

OniX OnPoint Animal Health Newsletter: Unveiling Insights in Infection, Immunity and Genetics Tackling Animal Health Challenges Through Breed Specificity, Allergic Responses, and Cross Species Dynamics onixonpoint.substack.com/p/onix-onpoi...

This week's issue of OniX OnPoint highlights significant developments in antibody-drug conjugate (ADC) technology across academic research, tech transfer opportunities, and commercial advancement. onixonpoint.substack.com/p/onix-onpoi...

𝐓𝐡𝐢𝐬 𝐔𝐩𝐜𝐨𝐦𝐢𝐧𝐠 𝐖𝐞𝐞𝐤'𝐬 𝐃𝐚𝐢𝐥𝐲 𝐈𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐟𝐫𝐨𝐦 𝐎𝐧𝐢𝐗 𝐎𝐧𝐏𝐨𝐢𝐧𝐭 (𝐌𝐨𝐧𝐝𝐚𝐲 - 𝐓𝐡𝐮𝐫𝐬𝐝𝐚𝐲): 𝐇𝐮𝐦𝐚𝐧 𝐇𝐞𝐚𝐥𝐭𝐡 (𝟕 𝐚𝐦 𝐄𝐒𝐓): rapidly evolving field of antibody-drug conjugate (ADC) technology. 𝐀𝐧𝐢𝐦𝐚𝐥 𝐇𝐞𝐚𝐥𝐭𝐡 (𝟗 𝐩𝐦 𝐄𝐒𝐓): a diverse range of animal health topics. 𝐊𝐞𝐞𝐩 𝐔𝐩 𝐰𝐢𝐭𝐡 𝐭𝐡𝐞 𝐋𝐚𝐭𝐞𝐬𝐭. 𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝐚𝐭: onixonpoint.substack.com

Despite some private support and partial payments, ongoing uncertainty threatens millions of vulnerable lives and jobs in the US humanitarian supply chain. apnews.com/article/usai... #USAID #Malnutrition #HumanitarianAid #PeanutPaste #ChildHealth #GlobalHealth #Nonprofits #FoodSecurity

Advancing Parkinson’s Therapy: Stem Cell-Derived Dopaminergic Neuron Transplants Show Promise in Early Clinical Trials onixonpoint.substack.com/p/advancing-...

Where Bees Won’t Go: How Cockroaches, Bats, and Beetles Pollinate the World’s Plants and Crops Beyond Bees: The Unsung Heroes of Global Pollination onixonpoint.substack.com/p/where-bees...

A Cerebrospinal Fluid Synaptic Protein Biomarker Predicts Cognitive Resilience and Decline in Alzheimer’s Disease CSF YWHAG:NPTX2 Ratio as a Robust Prognostic Indicator of Cognitive Impairment Beyond Amyloid and Tau Pathology onixonpoint.substack.com/p/a-cerebros...

Molecular characterization of feline caliciviruses isolated from several adult cats with atypical infection showing severe flu-like symptoms on a remote island in Ehime, Japan Atypical Feline Calicivirus Infection in Adult Cats on Aoshima Island, Japan onixonpoint.substack.com/p/molecular-...

Biotech companies developing drugs for hard-to-treat diseases and other ailments are being forced to push back clinical trials and drug testing in the wake of mass layoffs at the Food and Drug Administration. www.wsj.com/health/healt...

Netrin-1 and RGMa: Novel Regulators of Atherosclerosis-Related Diseases Exploring the Dual Roles of Neuronal Guidance Proteins in Atherosclerosis Progression and Therapy onixonpoint.substack.com/p/netrin-1-a...

Novel Hunnivirus Recombinant Strains in Cattle: A Chinese Perspective Uncovering Genetic Diversity and Regional Adaptation of Hunnivirus in Guangxi, China onixonpoint.substack.com/p/novel-hunn...

Novel Therapeutic Targets for Atherosclerosis: Targeting the FOSB-MECP2-Commd1 Pathway Unraveling the Molecular Interplay in Atherosclerosis: FOSB, MECP2, and Commd1 as Therapeutic Targets onixonpoint.substack.com/p/novel-ther...

Emergence of Novel Anaplasma Species in the Mediterranean Area: A Deep Dive Molecular Detection and Characterization of Emerging Anaplasma Species in Domestic Animals: An Expanded Analysis onixonpoint.substack.com/p/emergence-...

Emergence of Novel Anaplasma Species in the Mediterranean Area: A Deep Dive Molecular Detection and Characterization of Emerging Anaplasma Species in Domestic Animals: An Expanded Analysis onixonpoint.substack.com/p/emergence-...

A Blood Test for Pre-Symptomatic Parkinson’s Disease: Quantifying tRNA Fragment Biomarkers Revolutionizing Parkinson’s Diagnosis with Transfer RNA Fragment Analysis onixonpoint.substack.com/p/a-blood-te...

A brand-new seed nutrition system by a novel plant "gate" tissue was identified www.cell.com/current-biol...

The Anti-Inflammatory Potential of Tricyclic Antidepressants (TCAs): A Novel Therapeutic Approach to Atherosclerosis Pathophysiology Unveiling the Potential of TCAs in Combating Atherosclerosis Through Anti-Inflammatory Mechanisms onixonpoint.substack.com/p/the-anti-i...

From identifying innovative biomarkers for early disease detection to exploring novel pathogens and therapeutic approaches, these studies highlight significant advancements in feline and canine health. onixonpoint.substack.com/p/onix-onpoi...

OniX OnPoint Issue 37 highlights advancements in research and development related to Atherosclerosis. onixonpoint.substack.com/p/onix-onpoi...

BioMed X Institute opens its global crowdsourcing platform to help principal investigators in biomedical research who have lost their NIH funding to find alternative project sponsors among the global pharmaceutical industry. bmedx.com/news-events/...

Changes in Concentrations of Cytokines and Markers of Bone Turnover in Dairy Cows During Different Stages of a Production Cycle Investigating the Dynamics of Bone and Energy Metabolism, and Cytokine Profiles Throughout Lactation onixonpoint.substack.com/p/changes-in...

Identification of Novel Genetic Loci Affecting Age at Onset of Parkinson’s Disease: A Genome-wide Association Study Uncovering Genetic Variants Influencing Parkinson's Disease Onset in a Korean Population onixonpoint.substack.com/p/identifica...