According to new data by Huang et al., monthly tocilizumab may help stabilize kidney function in cases of chronic active antibody-mediated rejection, suggesting that IL-6 is a promising therapeutic target. #TXPforAll #KidneyTransplantation #OpenAccess tinyurl.com/3d7s65ud

#TBT to this week's featured top downloaded paper from 2022: Rapid Decline in Vaccine-induced Anti-SARS-CoV-2 Antibody Titers 3 Months After Kidney Transplantation: A Case Series From Belgium #Transplantation #Med tinyurl.com/pvyb426w

Together for a fairer future in transplantation! Leaders from around the world share bold strategies to advance diversity, equity & inclusion across our field. #Transplantation #DEI #TXPforAll tinyurl.com/mr3brn4r

Transplant Operative Assessment Tool offers structured feedback for surgical trainees—evaluating anatomy, technique, judgment & communication. 82 cases— strong reliability (α=0.94) clearly distinguished trainee levels—advancing competency-based training tinyurl.com/bddz24j7

New global study of 2,600 living liver donors! Robotic hepatectomy outperformed open & laparoscopic surgery — showing: 🩸 Less blood loss 💊 Lower pain 🏥 Shorter hospital stays ⚕️ Fewer complications. #TXPforAll #LiverTransplantation #TransplantTwitter tinyurl.com/2tuxzfaz

This study shows that liver transplants from ECMO-DCD donors using normothermic regional perfusion (NRP) are feasible — with good graft function and recovery — but require careful planning for optimal outcomes. #TXPforAll #Transplantation #OpenAccess tinyurl.com/375vwsv3

Chui et al. showed that MMR infections were extremely rare in over 313,000 solid organ transplant recipients. None occurred in individuals who were vaccinated before receiving a transplant, which highlights the importance of pretransplant MMR vaccination tinyurl.com/yc3v97kj

Freely downloadable paper introduces Australian Matchability Score (M-score), quantifying how HLA profiles affect kidney transplant access. Higher M-scores (harder to match) were linked to lower transplant likelihood and higher graft loss & rejection risk tinyurl.com/r8ntxtwx

For patients with alcohol-associated liver disease, pursuing living donor liver transplantation reduces waitlist dropout due to death or deterioration, with comparable survival to deceased donor LT. #TXPforAll #MedTwitter #LiverTransplantation tinyurl.com/2s3jn5zs

Adjustable Graft Failure Score (AdGFS) accurately predicts kidney graft loss using 1-year data. In >1,200 patients, 10-year survival fell from 89% to 23% across risk groups—supporting AdGFS as a tool for tailored care and clinical trial design. #TXPforAll tinyurl.com/4ckkanu8

#TBT to this week's featured top downloaded paper from 2022:Shiraz, Iran: The Largest Center for Pancreas Transplantation in the Middle East #Transplantation #Med tinyurl.com/mrypaysd

Freely downloadable paper shows biomarker dynamics vary between hypothermic (HMPO₂) and normothermic (NMP) perfusion in kidney transplants. Some biomarkers align across methods, but NMP provides key insights into function and reconditioning potential tinyurl.com/35tdhj2s

Study of >15 years of liver transplants shows ➡Severe obesity (BMI ≥40) increases graft loss & mortality in patients with low performance status, but not in those who are fitter. Performance before surgery makes all the difference. #TXPforAll tinyurl.com/yc3y6ye5

New hope for heart transplants! The HOPE device preserved DCD donor hearts for ~298 min in 5 North American patients with severe heart failure. Most had strong recoveries—one death unrelated to the heart. Promising results, but more studies needed tinyurl.com/yz34sfj4

Turning “inoperable” into “transplantable.” Using immune checkpoint inhibitors before liver transplant helped downstage advanced HCC—4 complete responses & 75% survival at 2 years. Early promise. #TXPforAll #LiverTransplantation #OpenAccess tinyurl.com/58bz3raz

Higher-dose TNX-1500 improved kidney xenotransplant survival (pig→baboon) but caused severe proteinuria, leading to drug loss & higher rejection risk. Next challenge: stop protein loss to boost graft success. #Xenotransplantation #TXPforAll @harvardmed tinyurl.com/47vmhah7

Across 10 European transplant centers, biopsy-based transcriptomics (BBT) use and indications vary widely. Moderate agreement with histology (κ=0.49) highlights the need for standardized integration into kidney transplant diagnostics. #TXPforAll #Kidney tinyurl.com/mub6m4dm

Frailty and sarcopenia double mortality in liver transplant candidates and impair recovery. Early detection, nutritional optimization, and personalized (p)rehabilitation are essential to improve outcomes. @BirminghamBRC #TXPforAll #LiverTransplantation tinyurl.com/4u4rr689

🫁 Byers et al. investigated whether lung function decline can predict survival after lung transplantation. 🫁#LungTransplantation #TXPforAll tinyurl.com/y9x64ttv

Inflammation continues to shorten transplant survival. 🧠💉This freely downloadable review paper discusses whether vagus nerve stimulation, which harnesses the body’s own anti-inflammatory reflex, can help protect grafts and improve outcomes. #TXPforAll tinyurl.com/b94k3nvb

BK polyomavirus in kidney transplant recipients: BKPyV QNAT reliably rules out BKVAN when negative, but positive results cannot distinguish true tissue-invasive infection. #TXPforAll #OpenAccess #Kidneytransplantation tinyurl.com/32kjdyvh

Extracorporeal photopheresis may prevent trained immunity and promote transplant tolerance, offering a potential new prophylactic strategy. #TXPforAll #OpenAccess #immunology tinyurl.com/ytccs2dv

In kidney transplant recipients, sotagliflozin (SGLT1/2 inhibitor) caused an initial eGFR dip—but changes were largely reversible after withdrawal. 🔹Well tolerated overall 🔹Adherence unaffected by eGFR reporting strategy Promising safety signal for KTRs tinyurl.com/mv9p49k3

#TBT to this week's featured top downloaded paper from 2022: Quality Metrics in Solid Organ Transplantation A Systematic Review #Transplantation #Med tinyurl.com/yynbnvb8

Top #Transplantation articles this month! 🔹 EVs for noninvasive heart rejection monitoring 🔹 Pregnancy after organ transplant: new guidance 🔹 Kidney care in heart transplant patients 🔹 Donor cfDNA in pediatric kidney rejection journals.lww.com/transplantjo...

The bioinformatic tool HLA-EP-RESOLVER accurately predicts antibody reactivity to rare HLA alleles using eplet analysis. Validated in sensitized patients, it helps identify acceptable/unacceptable antigens in the era of high-resolution donor typing. #HLA tinyurl.com/2m9nm6ek

Few upper extremity transplants are done worldwide, leaving patients with tough choices. This study shows how hopes, pressures, and quality-of-life concerns shape decision-making—and why better informed consent is key. #TXPforAll @DrMaceyLevan tinyurl.com/5b4rwj6a

Brain death triggers early complement activation in donor kidneys. High complement levels correlated with delayed graft function—highlighting a key target to improve outcomes. #TXPforAll #Transplantation #immunology #OpenAccess tinyurl.com/mvysuzk2

This new tool makes kidney allocation policy design faster—cutting simulation time from 6 hours to just 15 seconds. Faster models mean fairer, smarter decisions for patients waiting on a transplant. #TXPforAll #Transplantation #OpenAccess tinyurl.com/4ykbarrs

#TBT to this week's featured top downloaded paper from 2022: URINARY TRACT INFECTIONS IN RENAL TRANSPLANT RECIPIENTS IN THREE YEARS Recipients #Transplantation #Med tinyurl.com/4mpn66a9

Not all antibody tests agree: this study shows big differences between commercial assays for non-HLA antibodies in kidney transplant rejection. Standardization is urgently needed to clarify their role in AMR and graft loss. #TXPforAll #Transplantation tinyurl.com/c6s5mtk7

Undetected donor infections remain a concern in transplantation. Model shows the critical care interval before screening lowers residual risk—cutting it by ~44% for HCV, 23% for HIV, and 7% for HBV—supporting testing donors. @UniMelb tinyurl.com/4v9r9her

BK virus is a major cause of kidney transplant failure. This study shows that boosting virus-fighting immune cells in the lab—and adding checkpoint inhibitors—could make future treatments more effective at protecting transplanted kidneys. #TXPforAll tinyurl.com/5n76fk77

Graft rejection forces lifelong immunosuppression—bringing risks of infection & cancer. Veltman et al. explores extracorporeal photopheresis as a targeted alternative, highlighting immune pathways & biomarkers guide its use in solid organ transplantation tinyurl.com/mrm2ytjm

#TBT to this week's featured top downloaded paper from 2022: Immunosuppression and Reproductive Health After Kidney Transplantation #Transplantation #Med tinyurl.com/42untm8z

New in Transplantation! Patient Selection for Xenotransplant Human Clinical Trials: A Data-driven Approach. #TXPforAll #Transplantation tinyurl.com/4fwsv44c

Extracorporeal photopheresis = giving your immune system a light makeover 💡. This review explores how “photopheresates” could be supercharged—tweaking immune cells to either calm rejection or boost defense. #TXPforAll #Transplantation #OpenAccess tinyurl.com/2wztekfn

Study shows that the molecule miR-374b-5p worsens liver damage during transplantation and fuels liver cancer growth. Blocking it with a targeted gene therapy reduced tissue injury and cut tumor burden by 56%, pointing to a promising new treatment approach tinyurl.com/39c4vskz

Men and women face different risks while waiting for transplants. Younger women with kidney disease are at higher risk, older women often do better, and liver transplant risks shift with time—showing why sex matters in transplant care!! #TXPforAll tinyurl.com/4mywsrxm

#TBT to this week's featured top downloaded paper from 2022: Acute Kidney Injury After Liver Transplantation #Transplantation #Med tinyurl.com/ytb6wdrp

New swine study of intestinal transplantation shows that partial MHC class II matching can induce a unique “split tolerance” driven by donor regulatory T cells. @ColumbiaMed #TXPforAll #Transplantation tinyurl.com/mscuevjv

Extracorporeal photopheresis shows promise in reducing donor-specific antibodies and improving long-term transplant survival. #TXPforAll #OpenAccess #Transplantation tinyurl.com/md9b2h3w

Kidney disease is common after heart transplant. A Spanish expert consensus offers guidance on its management and when to consider kidney transplantation. #TXPforAll #Transplantation tinyurl.com/28mu34tp

Extracorporeal photopheresis is emerging as a novel therapy to regulate alloimmunity and prevent transplant rejection. #TXPforAll #OpenAccess #Transplantation tinyurl.com/yfv4ywau

#TBT to this week's featured top downloaded paper from 2022: High-risk Corneal Transplantation: Recent Developments and Future Possibilities #Transplantation #Med tinyurl.com/4hjeh49x

The great REVIEW paper highlights mitral regurgitation as a rare but complex issue after lung transplant. It summarizes incidence, mechanisms, and management strategies, underscoring the need for vigilant echo monitoring and further research. #TXPforAll tinyurl.com/2s3m268a

Case report: Successful ABO-incompatible living-donor liver transplant despite extremely high anti-B IgG titers (8192), plus 4 additional high-titer cases in the #rituximab era. Read the details! @KyotoU News #TXPforAll #OpenAccess #transplantation tinyurl.com/ytphkwy3

🌍 Applications open! The Transplantation Editorial Fellowship welcomes early-career researchers, clinicians & post-docs ready to shape the future of transplant science & publishing. 📖. #Transplantation #TXPforAll journals.lww.com/transplantjo...

This COOL review by Cutrone et al. explores advances in cryopreservation, how it compares to current preservation methods, and the logistical, ethical & regulatory steps needed for its use in #transplantation. #TXPforAll @DrAlissaCutrone @mgh_transplant tinyurl.com/hfnxnmuz

New in Transplantation Direct: Modernizing the Design Process for US Organ Allocation Policy — moving toward a continuous distribution framework for #kidneys #TXPforAll #OpenAccess #MedTwitter @MIT tinyurl.com/439e3phe