New insights into transplant tolerance: this study identifies IL-35 as a key mediator of bidirectional immune regulation after HLA-identical kidney #transplantation. Exosome-delivered IL-35 may help sustain local graft tolerance. #Immunology #TXPforAll tinyurl.com/4rbhjxn4

#TBT to this week's featured top downloaded paper from 2024:Five-day Wearable Respiratory Support With a Novel Ambulatory Pulmonary Assist System in an Awake Ovine Model #Transplantation #Med tinyurl.com/2s3edfrw

🌍 A new global milestone: 173,727 solid organ transplants were performed in 2024—the highest number ever recorded. Growth was driven by increased deceased donation, particularly donation after circulatory death. #Transplantation #TXPforAll tinyurl.com/bddw5snt

From bench to bedside: this review highlights the latest advances in vascularized composite allotransplantation (VCA), including innovative immunotherapies and improving outcomes in uterus, face, and limb transplantation. tinyurl.com/5n798bv8

🩸 EPO does far more than make red blood cells. This review reveals its surprising role as an immune regulator—promoting transplant tolerance, calming inflammation, and reshaping immune cell function. #Transplantation #TXPforAll tinyurl.com/nb9mcjvb

📊 Body surface area- and kidney function-based valganciclovir dosing achieved target drug levels more often than weight-based dosing and was linked to faster CMV clearance. #TXPforALL #Transplantation tinyurl.com/24jpfz79

#TBT to this week's featured top downloaded paper from 2024:Elevation of Donor-derived Cell-free DNA Before Biopsy-proven Rejection in Kidney Transplant #Transplantation #Med tinyurl.com/3nyh9efb

Can engineered liver tissue help solve the donor shortage? A new oxygenation system using decellularized livers and artificial red blood cells improved the function and engraftment of hiPSC-derived liver tissue in mice. #TXPforALL #Transplantation tinyurl.com/mv9f8he4

🫁 In a mouse model, delayed treatment reduced chronic airway injury and inflammation, but earlier therapy provided greater protection. #LungTransplantation #CLAD #TXPforALL tinyurl.com/8p7tjfdz

Who benefits from SLKT? Analysis of US liver transplants shows: No survival benefit of SLKT when pretransplant eGFR ≥30. Clear survival benefit for patients with eGFR <30. The findings support stage-specific SLKT allocation and OPTN "Safety Net" policy. tinyurl.com/yzjjpr2r

In a study of 1,146 liver transplants with up to 10 years of follow-up by Pollmann et al., sex mismatch was not an independent predictor of survival after adjustment. Bottom line: donor sex alone should not limit donor selection. 🫀➡️🫁 tinyurl.com/45s85xf4

#TBT to this week's featured top downloaded paper from 2024:Mechanistic Understanding of EBV+Lymphoproliferative Disease Development After Transplantation #Transplantation #Med tinyurl.com/yvns794d

French nationwide study: High-Emergency Lung Transplantation (HELT) was linked to higher postoperative morbidity but not higher 1-year mortality after adjustment. Findings support HELT as an effective strategy for the sickest patients. tinyurl.com/2w38ubkc

New study shows remarkable growth in U.S. Good Samaritan kidney donation. From 2000–2024, annual donations increased from 17 to 439. Voucher-based nondirected donation grew from 2 donors in 2015 to 314 in 2024, representing 72% of Good Samaritan donations. tinyurl.com/msd6wbxb

After liver transplantation, adding everolimus to CNI therapy: ✅ Reduced cancer risk ⚠️ Increased infection risk 💰 Remained highly cost-effective When accounting for cancer, infection, and kidney dysfunction, EVR-based therapy delivered good value. tinyurl.com/ye93kk9p

Prior Roux-en-Y gastric bypass may increase the risk of malabsorption, sarcopenia, recurrent steatohepatitis, and graft loss after liver transplantation. These cases highlight the importance of careful nutritional assessment and long-term monitoring. tinyurl.com/bpn6jke3

#TBT to this week's featured top downloaded paper from 2024: Cancer Surveillance in Solid Organ Transplant Recipients With a Pretransplant History of Malignancy: Multidisciplinary Collaborative Expert Opinion #Transplantation #Med tinyurl.com/3mw579zt

Peer mentorship may reduce kidney transplant inequities. Black and Hispanic recipients emphasized need for early, culturally tailored support from trusted mentors. Providers endorsed mentorship programs to improve engagement, trust, and transplant success. tinyurl.com/zux93eck

#TBT to this week's featured top downloaded paper from 2024: Immune Monitoring Assays: Predicting Cytomegalovirus and Other Infections in Solid Organ Transplant Recipients. #Transplantation #Med tinyurl.com/zpjv73px

Should age or cancer history determine kidney transplant access is addressed in this paper by Lim et al. #TXPforAll #Transplantation #OpenAccess tinyurl.com/4upud6vk

CTLA4-Ig combined with anti-IL-6/IL-6R therapy improved graft function, resolved CNI toxicity, reduced donor-specific antibodies, and promoted a more regulatory immune profile. #TXPforAll #KidneyTransplantation #OpenAccess tinyurl.com/37fpzavf

🦠Norovirus remains a major challenge after solid transplantation! This scoping review highlights promising signals for oral immunoglobulin and fecal microbiota transplantation, but robust clinical trials are urgently needed. #TXPforAll #Transplantation tinyurl.com/j8mxd5jx

In this paper, Maluf et al. demonstrated that the molecule big mitogen-activated kinase-1 (BMK1) may protect against liver ischemia-reperfusion injury. Higher BMK1 activity was associated with improved graft function. tinyurl.com/4amwfxuk tinyurl.com/49mz6w4j

🧪Can urine recirculation improve kidney preservation? In discarded human kidneys, urine recirculation during normothermic machine perfusion supported longer perfusion times and a more favorable metabolic profile. tinyurl.com/msaeyv83

#TBT to this week's featured top downloaded paper from 2024: Normothermic Regional Perfusion in Controlled Donation After the Circulatory Determination of Death: Understanding Where the Benefit Lies #Transplantation #Med tinyurl.com/2vpyurvr

Early unplanned reoperation after liver transplantation occurred in one in six recipients and more than doubled 90-day mortality risk. Failure-to-rescue rates improved over time, reflecting better recognition and management of postoperative complications. tinyurl.com/mrxh8wfz

💪Muscle loss after kidney transplantation may be more than a marker of frailty. CT-based body composition analysis identified accelerated skeletal muscle decline in patients with allograft dysfunction and predicted poorer survival. #TXPforAll tinyurl.com/yrww5yav

🦠Chronic high EBV load after pediatric liver #transplantation is a major warning sign: 1 in 5 affected children developed #PTLD. Early EBV DNAemia, CMV infection, and EBV D+/R− status identified those at highest risk. #TXPforAll #EBV #OpenAccess tinyurl.com/2hp3dmx2

Brazil continues to lead in kidney transplantation. New reforms improve equity and access by addressing highly sensitized patients, donor typing gaps, and regional disparities—showcasing how evidence-based policy can strengthen transplant outcomes. tinyurl.com/mr4ca8e

Creating inclusive, respectful environments where every voice is heard can improve collaboration, reduce burnout, and enhance patient care. Time for transplant-specific guidelines on communication, inclusion, and minimizing hierarchy. tinyurl.com/57676fjn

This study highlights robust CLAD development across models and supports B6-background donor lungs as a valuable platform for studying chronic rejection and testing new therapies after lung transplantation.#TXPforAll #Immunology #OpenAccess tinyurl.com/bdze57f3

#TBT to this week's featured top downloaded paper from 2024: Equitable Access to Deceased Donor Livers in the United States: Are We There Yet? #Transplantation #Med tinyurl.com/5n64btc6

In this, Tremblay et al. demonstrated that VEL-101, exhibited favorable safety, predictable pharmacokinetics, and sustained receptor occupancy in a Phase 1 trial. Results support the drug's potential as maintenance immunosuppressant for kidney transplants. tinyurl.com/5c4vcw9

Living kidney donors reported improving pain control with very limited opioid use by 2 weeks after donation. #TXPforAll #Transplantation #OpenAccess tinyurl.com/2fhm7f6b

This brief communication highlights the promise of “human-in-the-loop” approaches, where AI supports data organization while expert researchers ensure accurate interpretation. #TXPforAll #OpenAccess tinyurl.com/3naz3hw3

Pacemakers may offer a safer pacing option for solid organ transplant recipients at high infection risk. Early experience with the Aveir LP platform showed successful implantation, stable performance with no device-related infections during follow-up. tinyurl.com/yck2mnet

#TBT to this week's featured top downloaded paper from 2024: Outcomes of Liver Transplantation From Hepatitis C Virus–positive DCD Donors and Its Utilization Among Centers in the United States #Transplantation #Med tinyurl.com/yvjuxtjk

This #freelydownloadable paper shows that plasma proteomics could offer an early warning system for late kidney graft failure. This improves prediction upon current clinical markers and supports more personalized, long-term transplant monitoring. tinyurl.com/y4mksbtr

This study by Wang et al. shows that pediatric donor kidneys can successfully adapt and grow after transplantation into pediatric recipients, supporting strong long-term function and reinforcing the feasibility of pediatric-to-pediatric kidney tinyurl.com/47797cac

@WTC2025 congress showcased innovation that is shaping the future of beta-cell replacement therapy. Pancreas and islet transplantation continue to advance rapidly, with major progress in organ preservation, immunosuppression, and regenerative therapies. tinyurl.com/wbtrmwmz

Can normothermic machine perfusion (NMP) delay acute rejection in vascularized composite allotransplantation is addressed in this research paper by von Reiterdank et al. #TXPforAll #Transplantation #OpenAccess tinyurl.com/mr22ada4

#TBT to this week's featured top downloaded paper from 2024: Representation of Women Authorship in the Top 5 Transplantation Journals in the United States #Transplantation #Med tinyurl.com/yb7zw5af

Prehabilitation in solid organ transplant candidates shows early promise: a meta-analysis of 956 patients found it may shorten hospital stay and improve functional capacity, though effects on complications and quality of life remain unclear. #TXPforAll tinyurl.com/55e3furp

NMP during liver preservation in SLK transplantation was linked to better kidney outcomes vs SCS: lower functional DGF, improved early eGFR, and reduced dialysis at 6 months. #TXPforAll #Transplantation tinyurl.com/5n97d5u3

Study of 6 U.S. OPOs found 40,978 excluded clinically, leaving 4,480 suitable donors (7.5%–12.4%). Hospitals referred >99% of eligible cases, supporting referral-based donor potential measurement as a more accurate alternative to administrative methods. tinyurl.com/36s3kxzc

Pediatric-to-pediatric kidney transplants show strong adaptability: smaller donor kidneys grow rapidly—reaching age-appropriate size within ~6 months—and support good function, reinforcing this strategy as safe and effective. #TXPforAll #OpenAccess tinyurl.com/47797cac

#TBT to this week's featured top downloaded paper from 2024: Outcomes of DCD Liver Transplant Using Sequential Normothermic Regional Perfusion and Normothermic Machine Perfusion or NRP Alone Versus Static Cold Storage #Transplantation #Med tinyurl.com/4sbrvj5c

This paper shows that, despite better early outcomes, progress has plateaued in the last 50 years of kidney transplant data. Long-term graft survival is declining in the modern era due to older, more comorbid recipients and rising infection-related deaths. tinyurl.com/2p9ucusb

Genetic testing is reshaping kidney transplant evaluation: over one-third of candidates had a genetic diagnosis often clarifying cause and guiding donor decisions. #TXPforAll #OpenAccess #Transplantation tinyurl.com/3zuejwwc

A “lung-on-a-chip” model brings transplant research closer to reality replicating cold storage injury with human cells and revealing barrier loss, inflammation, and gene changes. A powerful new tool to study lung transplant injury and test therapies. tinyurl.com/3sphs9zf