Dr. Stanley Gartler’s life was defined by unwavering integrity, analytical precision, and a profound commitment to scientific truth. His legacy lives on in every laboratory that values experimental reproducibility and curiosity-driven research. https://www.gs.washington.edu/stanley-gartler/

A lot to look out for at BIO! From the regional pavilions (from Italy to Ohio), talks on NAM validation and function, and help with mouse model ideas (even finding the right mouse with the MMRRC!). Stop by booth 4121. https://convention.bio.org/landing

All about the connection...The MMRRC has a great methbod to eliminate guesswork in experimental design via the Strain GQC Report to map genomic variations and find improved information from model selection. Read More Here: https://www.science.org/doi/10.1126/science.aec3177

Allele in a day's work: A new MMRRC paper delivers a framework to optimize design and elevate reporting in mouse models. 🔬 Far from focusing on flawed models, the work is about supporting researchers and improving scientific rigor. 🔗 https://www.science.org/doi/10.1126/science.aec3177

We are quite happy for Dr. Franklin on all his achievements, his mentorship, and his help with research the world over! For more info visit: https://cvm.missouri.edu/craig-franklin-receives-james-russell-lindsey-distinguished-lectureship-award/

Who knew the YAK could hold the secret to healing the human brain? (Hint - gene is Retsat) Source: https://www.the-scientist.com/a-genetic-mutation-found-in-yaks-boosts-myelin-repair-74204

An update to our podcast series, this one focusing on some ideas, both old and new, as to the age old question, Why a Mouse Model?...https://mbp.mousebiology.org/news/why-a-mouse/

A new Scn8a R1872W mouse model is paving the way for CRISPR-based epilepsy treatments. Source: https://www.jci.org/articles/view/196402

New research explores a promising, low-toxicity transplant strategy for diabetes. Learn more: https://www.jci.org/articles/view/201105#SEC7 And to view diabetic specific models, visit: https://www.mmrrc.org/catalog/StrainCatalogSearchForm.php?search_query=DOID:9352

When global competitors are accelerating their investments in biomedical research, America cannot afford to fall behind...https://www.fiercebiotech.com/research/despite-delays-nih-grants-generated-250-return-366b-investment-2025-report?utm_medium=email&utm_source=nl&utm_campaign=LS-NL-FierceP

Advances in organ and computer models are raising the prospect that some animal experiments could be eliminated. But there are still huge hurdles to overcome. Read More Here: https://postly.click/5vU

The research landscape is approaching a turning point. Proposed cuts would weaken science—especially physiology—that drives medical breakthroughs. This overview sets the stage for a deeper look at what’s at stake and why this full report matters: https://www.physio

Every UC Davis breakthrough starts with a question. The Mouse Biology Program supports researchers, turning discoveries into solutions. For more info about the impact at UC Davis, visit: https://ucdavis.edu/labs-to-lives 🔊Watch with sound!

Scientists, with initial mouse models findings, expand results in organoids to confirm nerve-repair treatment can trigger healing in human spinal tissue. Source: https://www.sciencealert.com/scientists-grew-mini-human-spinal-cords-then-made-them-repair-after-injury

🫱A new polymer delivery system may allow insulin to be absorbed through the skin and control blood sugar without injections, at least in animal studies! Source: https://www.nature.com/articles/s41586-025-09729-x

In vivo & in silico: Compounds linked to traditional medicine reduced anxiety-, depression-, and pain-related behaviors in mice. Computer modeling suggested key compounds and targets, while mouse studies showed how those predictions played out biologically: https://doi.org/10.100

Turning Back Immune System Aging: A new method instructs liver to pump out specific proteins, effectively hitting the "reset" button on an aging immune system to restore youthful defense capabilities. Source: https://www.livescience.com/health/immune-system/an-experimental-mrna-treatment-counters-i

Turning Back Immune System Aging: A new method instructs liver to pump out specific proteins, effectively hitting the "reset" button on an aging immune system to restore youthful defense capabilities. Source: https://www.livescience.com/health/immune-system/an-experimental-mrna-treatment-counters-i

We’re grateful for another year of collaboration and support. Please enjoy this short thank-you video from the UC Davis Mouse Biology Program (sound on):

National Security Commission on Emerging Biotechnology warns U.S. science is getting outpaced: https://www.fiercebiotech.com/biotech/us-commission-recommends-federal-research-revamp-avoid-losing-global-biotech-edge?utm_medium=email&utm_source=nl&utm_campaign=LS-NL-FierceBiotechResearch&oly_enc

The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine. A quiet change means the government is making fewer bets on long-term science. https://www.nytimes.com/interactive/2025/12/02/upshot/trump-science-funding-cuts.html?unlocked_article_code=1.5k8.aC_b.voYFMu6ICX8W&smid=url-share

Scientists found that HSL not only breaks down fat but also works inside the nucleus of to keep adipose tissue healthy, explaining why people lacking HSL lose fat instead of becoming obese. https://scitechdaily.com/obesity-discovery-

The research landscape is approaching a turning point. Proposed cuts would weaken science—especially physiology—that drives medical breakthroughs. This overview sets the stage for a deeper look at what’s at stake and why this full report matters: https://www.physio

The FDA has approved Kygevvi (doxecitine + doxribtimine) as the first-ever treatment for Thymidine Kinase 2 Deficiency (TK2d), offering hope to patients with this devastating mitochondrial disease. https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-1st-

Scientists have made major progress in understanding and treating thymidine kinase 2 deficiency (TK2d), a rare genetic disorder that weakens muscles by disrupting mitochondrial DNA maintenance. https://postly.click/ABY

James D. Watson, part of the team that uncovered the double-helix structure of DNA in 1953 with Francis Crick, Rosalind Franklin and Maurice Wilkins, has died at 97. His work marked a notable moment in biology. https://www.yahoo.com/news/articles/james-watson-co-discoverer-double-1957www.yahoo.com/n

As oocytes grow, H2A.Z shifts from marking active genes to spreading across broader, silent DNA regions, working hand-in-hand with another modification to support healthy meiosis and prepare the egg’s epigenetic blueprint for early embryonic life. .nature.com/articles/s41594-025-01573-xMore Info:

IMPC Strategic Conference ‘Insights from the Past, Shaping the Future’ Program and key information 👉 https://www.mousephenotype.org/news/2025-virtual-impc-conference-registration-and-agenda/ Free Registration 👉https://tinyurl.com/yz7znkde

🎉 Big congrats to Dr. Eric Green for receiving the American Society of Human Genetics Leadership Award — a standing ovation for visionary leadership in genomics! Read About it here: https://www.genengnews.com/topics/omics/eric-green-receives-ashg-leadership-award-to-standing-ovation/

"Animal models provide insights that alternative approaches can’t. A heated debate about which method is better is distracting researchers from doing good science." https://EcKc5wILd4%3D

MMRRC is in Boston at ASHG for the next 3 days - booth 1327! For more info: https://meetings.ashg.org/event/ASHG25/program/schedule

What Baby KJ’s CRISPR Breakthrough Really Tells Us. Reflections on the balance between hope and realism — new therapies are exciting, but they’re not universal cures yet. Read More: https://www.statnews.com/2025/10/09/crispr-cure-baby-kj-rare-diseases-personalized-gene-editing-drugs/?_hsmi=38470699

Congratulations to Drs. Brunkow, Ramsdell, & Sakaguchi! For More information: https://postly.click/ECH

“...the first step out of the maze for young men begins by reasserting to them the virtue of hard work — an often grueling but indispensable part of finding the right answers in science.” Read the essay with our gift article here: www.nytimes.com/2025/10/03/o...

Some good research "food for thought... " https://www.nature.com/articles/d41586-025-02920-0?utm_source=Live+Audience&utm_campaign=b2c87a0562-nature-briefing-daily-20250916&utm_medium=email&utm_term=0_-33f35e09ea-49915704

🌟 We’re proud to support the Rare Diseases Are Not Rare! Challenge—working together for faster treatments. With over 10,000 rare diseases, collaboration is key to speeding discovery and care. Learn more: https://www.challenge.gov/?challenge=rare-diseases-are-not-rare-2025-challenge

In this latest episode, we reflect on the past year at the Mouse Biology Program — what we’ve achieved, the challenges we’ve tackled, and how our work is shaping the future of research.

A great question... https://www.theatlantic.com/health/archive/2025/08/nih-funding-whiplash/683773/?gift=4lmIFlDypD2qizi37OjlOFcAyBgKZPvOqwBmeZV_gRM&utm

Righting the Ship... https://www.nature.com/articles/d41586-025-02331-1.epdf?sharing_token=l7tRdDqzPMtZY_fH3UilNdRgN0jAjWel9jnR3ZoTv0MN1Qa0Vg7jBoDX-os-NGcnreSmdlunxc76Fm4BFTVgIRcWiJXH5_Mm6B0xbQzS9AVWJf16F2hpzcCoBM1I1qXdjXso5QNekkp_M4xECg8pJmszLDG-Y5fzLs2SaPwXEMA%3D

"To be clear, there is no replacement yet for animal research in biomedical science...it remains to be seen how faithfully these [stem cell] reprogrammed cells and organoids mimic various complex biological processes.

Mice treated with a copper drug repaired faulty brain proteins, reversing Parkinson’s symptoms and offering new hope. Source: https://www.goodnewsnetwork.org/scientists-reverse-parkinsons-symptoms-in-mice-we-were-astonished-by-the-success/

What happens when lifesaving research quietly disappears? A look at critical NIH-funded projects lost to sudden budget cuts: projects.propublica.org/nih-cuts-res...

Imagine a future where the smell of menthol could alleviate some of the worst symptoms of Alzheimer’s disease. Read More: https://theconversation.com/when-mice-with-alzheimers-inhaled-menthol-their-cognitive-abilities-improved-230330

Scientists used gene-edited mice to test a custom therapy for a deadly infant liver disease—then saved a real child! Source: www.nejm.org/doi/full/10....

Food for thought - "There’s no mystery to innovation and economic growth; the US must nurture its scientists or find out the hard way.

Something different: 3D-printing inside a living mouse’s bladder using sound waves! No cuts. Just ultrasound. Curious? Find out in Science: www.science.org/doi/10.1126/...

Scientists can now guide how cells self-organize using internal forces. Imagine using this to grow tissues in mice faster to test new therapies. Source: journals.aps.org/prl/abstract/10.1103/PhysRevLett.134.148301

Mouse studies reveal gut viruses help antibiotics — without them, bacteria resist treatment. 🐭🦠Source: cell.com/cell-host-microbe/abstract/S1931-3128(25)00135-0

Celebrating BRAD today at UC Davis! A lot is going on at Gladys Valley Hall:

​Sweden launches PROMISE, a national initiative to integrate large-scale multi-omics data with healthcare and research. By bridging fragmented datasets and improving data access, Sweden aims to unlock the full potential of precision medicine.