Aneesh Sathe
@aneeshsathe.com
📤 6076
📥 1868
📝 1858
aneeshsathe.com 🧪🧬💻🤖🔬🦠🩺💊🐍
half way through an article about life and consciousness from Harpers and realized that I must write for myself…
about 2 hours ago
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Trying to understand how to stay grounded when knowledge behaves like a living thing. Four early-modern voices—More, Montaigne, Bruno, Ibn Khaldun—turned out to have surprisingly current lessons.
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Four Early-Modern Tempers for a World That Can Summon Itself
This is a partial synthesis of the books read through 2025 in the Contraptions Book Club. We live in a moment when the whole of human culture has become strangely available, no longer just an archive but something that behaves like a responding presence. A sentence typed into a search bar or messaging window returns citations and, more strikingly, continuations: pastiche, commentary, new variations of ideas that never existed until the instant we requested them.
http://aneeshsathe.com/2025/12/06/four-early-modern-tempers-for-a-world-that-can-summon-itself/
about 18 hours ago
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much love to everybody
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much love to everybody
xkcd published this wonderful piece: want to feel old?
http://aneeshsathe.com/2025/11/24/much-love-to-everybody/
12 days ago
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Aneesh Sathe
Nature Portfolio
17 days ago
A paper in Nature Biotechnology presents CellWhisperer, which uses multimodal learning of transcriptomes and text to answer questions about single-cell RNA-sequencing data.
go.nature.com/3XqzItR
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The potato and…
https://clacks.aneeshsathe.com/3m5owj3q7ls2y
21 days ago
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favorite movies Friend asked if Constantine was my favourite movie… I mean Neo and the librarian in one movie?? Yes please! but… Not my favorite though… that would be between Notting Hill, The Mummy, and The Matrix. None of them are good movies — in the way that Perfect Days and sooo many others…
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favorite movies
Friend asked if Constantine was my favourite movie… I mean Neo and the librarian in one movie?? Yes please! but… Not my favorite though… that would be between Notting Hill, The Mummy, and The Matrix. None of them are good movies — in the way that Perfect Days and sooo many others are — but they are my movies.
http://aneeshsathe.com/2025/10/25/favorite-movies/
about 1 month ago
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Rhyme, collected RhymeManaged memory leaks.EverythingNeatly tucked away. The poets freedBy print. Hackers Tamed themselves.Linting,Hinting, diff-printing Bolt cutters:vibe- image: Rain, Steam and Speed
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Rhyme, collected
RhymeManaged memory leaks.EverythingNeatly tucked away. The poets freedBy print. Hackers Tamed themselves.Linting,Hinting, diff-printing Bolt cutters:vibe- image: Rain, Steam and Speed
http://aneeshsathe.com/2025/10/17/rhyme-collected/
about 2 months ago
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Charles Lloyd: Tribute to Zakir
https://clacks.aneeshsathe.com/3m2zpetn3f222
about 2 months ago
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Kris knife
A heartbreaking scene from history.
https://clacks.aneeshsathe.com/3m2gfu4jnlk2n
2 months ago
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reposted by
Aneesh Sathe
Prose and Khans
2 months ago
add a skeleton here at some point
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Aneesh Sathe
Tim Kellogg
3 months ago
and it works! they made a tiny 8B model that holds up well against many large MoE models
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The Little Prince
No. 4
https://clacks.aneeshsathe.com/3lzutnisiyc2o
2 months ago
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was away, what did i miss? (i'm aware of the politics). Give me tech, stats, AI, Bio... My brain is so hungry
2 months ago
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Gondwana
https://clacks.aneeshsathe.com/3lyrivc5j2k2x
3 months ago
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Aneesh Sathe
Boris
3 months ago
Hey, wanna try something with me? This is an editable document. Add to the story. Share the link so others can contribute
leaflet.pub/aefd4342-396...
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Line?
https://leaflet.pub/aefd4342-3968-4f2e-8194-e7b9fa7cc685
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I mean if
@gracekind.net
says so, I must be
add a skeleton here at some point
3 months ago
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Baldur’s Gate
https://clacks.aneeshsathe.com/3lycn2iz2j22h
3 months ago
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reposted by
Aneesh Sathe
Stein Makes Games - Wishlist Dig Dig Boom
3 months ago
Reddit opinions on Hollow Knight 10 years ago
#indiedev
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Aneesh Sathe
B. Ricardo Brown, PhD
3 months ago
Johnson, Adayshia (2022). “Ibn Khaldun’s Views on Race: Influences by Early Life/Childhood, Climate, Geography, and Geographic Segmentation.” The Macksey Journal: Volume 3, Article 95.
#HistSTM
#HistSci
#Sociology
mackseyjournal.scholasticahq.com/article/5565...
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To remedy this I have gone from simple quoting to drug hunting
add a skeleton here at some point
3 months ago
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reposted by
Aneesh Sathe
Prof Andy Field
3 months ago
A shout out for
@nrennie.bsky.social
fab book on data viz!
nrennie.rbind.io/art-of-viz/
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The Art of Data Visualization with ggplot2
https://nrennie.rbind.io/art-of-viz/
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I just wanna say I was playing Qud before all this award brouhaha. Congrats to everyone!!
add a skeleton here at some point
3 months ago
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Zen or RDF?
3 months ago
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There is no center, there is no base, there is no I nor you. All we have each other.
https://clacks.aneeshsathe.com/3ly2xpb74422z
3 months ago
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Aneesh Sathe
Jenka
4 months ago
Before COVID we didn’t even know a virus causes multiple sclerosis. They just figured out how it does it.
www.nature.com/articles/s41...
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EBV induces CNS homing of B cells attracting inflammatory T cells - Nature
Epstein–Barr virus infection generates a neuroinvasive B cell subset, which recruits activated T cells to the central nervous system, promoting multiple sclerosis.
https://www.nature.com/articles/s41586-025-09378-0
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Dunno why people trying
@leaflet.pub
gets me excited. But it does!
add a skeleton here at some point
3 months ago
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The coolest bit (as much as I understand it) is that a nucleus-free ova is a niche big enough to be a stage for this genetic drama
add a skeleton here at some point
3 months ago
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h/t
@scientificdiscovery.dev
for pointing me to this book
add a skeleton here at some point
3 months ago
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Cell Biology by the Numbers
https://clacks.aneeshsathe.com/3lxyicwmy2s2p
3 months ago
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Aneesh Sathe
Saloni
3 months ago
NEW EPISODE of HARD DRUGS! “5 hours is too long!” some of you said after our first episode. So our second episode is 20 minutes 🤭
@jacobtref.bsky.social
and I explore the world of proteins: how proteins fold into complex shapes, why complexity matters, how crowded and dynamic a cell really is.
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Proteins: Weird blobs that do important things
https://open.spotify.com/episode/6L9MzozVBaDM0aimUzN6mW?si=ee8229c447b848c7
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Bio — it’s there to break your mind
One mom two species
https://clacks.aneeshsathe.com/3lxygulnhvc26
3 months ago
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Aneesh Sathe
brendan
3 months ago
I've noticed several great ~linkblogs~ on
@leaflet.pub
lately — here's a lil thread! oh and btw for my linkblog friends & similar collection-makers etc. using Leaflet — we just added iframe embeds! for a bunch of these, particularly useful for nice YouTube video display…but plz test others too!
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We need that deep sea manure
https://clacks.aneeshsathe.com/3lxsq62zmt22r
3 months ago
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The best kind of science writing
https://clacks.aneeshsathe.com/3lxsj2kbyb223
3 months ago
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The only kind of article writing I want
add a skeleton here at some point
3 months ago
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Back to back SD Zoo and SeaWorld Days
https://clacks.aneeshsathe.com/3lxqt2zv6es2v
3 months ago
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Aneesh Sathe
Leaflet
3 months ago
"wait so you're making an app that's part gdocs/notion & part substack/wordpress & built on atproto & fully open source & I can login w/ bsky & own my data & theme my pubs & add custom domains & there's a whole block editor & it's just three of you making it & also it's free?" yes that's correct :)
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Aneesh Sathe
pony pony huckabuck
3 months ago
my uncle just called someone "li-curious" (linux curious) lmao
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Now this is a great Discworld Thread
https://clacks.aneeshsathe.com/3lxlune7to224
3 months ago
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The way it should be. Bokeh bokeh! 😍
add a skeleton here at some point
3 months ago
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It can also be self-hosted if the need arises
add a skeleton here at some point
3 months ago
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reposted by
Aneesh Sathe
Patrick Vallely
3 months ago
"Pat, why do you carry that ridiculous 600mm lens on long hikes?" Buddy, I can see mountains reflected in the eyes of a trailside pika.
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The future of knowledge graphs
What I’m waiting for is the DuckDB knowledge graph
https://clacks.aneeshsathe.com/3lxjdei5gtk2p
3 months ago
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https://clacks.aneeshsathe.com/3lxjc3makts2k
3 months ago
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Crazy money for crazy science
https://clacks.aneeshsathe.com/3lxjbtzrxhc2p
3 months ago
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A book on chapters
https://clacks.aneeshsathe.com/3lxjbhh65a22k
3 months ago
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Exactly!!
add a skeleton here at some point
3 months ago
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Part of Summer of Protocols again this year
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Part of Summer of Protocols again this year
https://clacks.aneeshsathe.com/3lxiqqt6j5k2p
3 months ago
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reposted by
Aneesh Sathe
Olivier Simard-Casanova
4 months ago
@leaflet.pub
is such an innovative platform If you select some text (1), a tooltip appears that allows you to share the selection as a quote on Bluesky (2) If you click the Quotes icon (3), a panel showing all quotes appears (4) It's a terrific integration between blogging and microblogging
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https://clacks.aneeshsathe.com/3lxilmas6tc24
3 months ago
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