Ghizlane Tahiri Zainane
@ghizlane-tahirizn.bsky.social
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Postdoctoral Researcher at the University of Neuchâtel
Excited to share our study uncovering how coordinated gene family evolution enabled dimorphic Mucorales to encode two distinct life forms within a single genome, revealing new regulators of fungal dimorphism and adaptation.
www.nature.com/articles/s41...
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Coordinated gene family evolution shapes the genome of dimorphic Mucorales - Nature Communications
Dimorphic organisms switch between two distinct life forms, but how a single genome controls the genetic program for both states is unclear. The study identifies hundreds of convergently evolved gene ...
https://www.nature.com/articles/s41467-026-68866-7
about 1 month ago
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Our latest findings show that ChoC-dependent phosphatidylcholine biosynthesis is essential for cellular integrity and virulence in Rhizopus microsporus, highlighting ChoC as a promising antifungal target against mucormycosis.
www.tandfonline.com/doi/10.1080/...
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Phosphatidylcholine biosynthesis via ChoC is crucial for cellular integrity and virulence in Rhizopus microsporus
Rhizopus microsporus is an opportunistic fungal pathogen and a prominent etiological agent of mucormycosis, a life-threatening invasive fungal infection. In this study, we investigated the role of ...
https://www.tandfonline.com/doi/10.1080/21505594.2026.2654119?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
about 1 month ago
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Excited to share our new paper 🧬
doi.org/10.1371/jour...
We studied how mucoralean fungi interact with immune cells during early infection and identified genes involved in their ability to cause disease.
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A BRCT domain-containing protein induced in early phagocytosis plays a crucial role in the pathogenesis of the mucoralean Rhizopus microsporus
Author summary Mucormycosis is a severe fungal infection caused by Mucorales species, often affecting immunocompromised individuals. These pathogens can survive inside macrophages, immune cells that n...
https://doi.org/10.1371/journal.ppat.1013653
2 months ago
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reposted by
Ghizlane Tahiri Zainane
Carlos Lax
2 months ago
Go outside. Get some light. Forget about that toxic relationship you're addicted to. Our latest work in
@isme-microbes.bsky.social
shows how light can replace the function of endosymbiotic bacteria hosted within fungal hyphae for asexual reproduction.
academic.oup.com/ismej/advanc...
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Light restores sporulation in Rhizopus microsporus cured of its endosymbionts, unveiling their role in fitness and virulence
Abstract. Rhizopus microsporus is a major cause of mucormycosis, an infection caused by Mucorales that increasingly affects immunocompromised individuals.
https://academic.oup.com/ismej/advance-article/doi/10.1093/ismejo/wrag047/8644008
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