Always innovating. No cap. lol

If you are 25 years old, you have never known a moment where humans have not been in space. To celebrate the ISS's 25 years of permanent human presence in space, you can relive those moments thanks to Ben Fiest, who created ISS in Real Time. Visit here --- > issinrealtime.org #ISSInRealTime

From the first sentence of the Intro 🔥 and throughout, great paper and tool. Even the population PCA plot made a statement, really nice work.

Exciting work! And one more important pathway to add to the enrichment tests.

On urging an evidence-based approach to COVID origin. Reasonable review of the underlying logic.

The only opportunity here is finally to force Congress address it directly. They’ve been talking about it, with nothing definitive to address. Now, if nothing else (and it’s as close to nothing as it can be) there’s no more denying it. Congress passed flat budget, OMB acts as if they had cuts.

Best thread about the best boys and girls.

I recently ran a session at CSAMA with Laurent Gatto and this is the way. "Good enough" with knowledge of the tools that can help you get there. Here's some of the recs from the paper.

Amazing paper, exactly what spatial transcriptomics is made for, and look at this system! Each hippocampus region lit up, it’s stunning. I was thrilled to play a part! #keepCA2weird

Researchers learned a function of enzyme MORC2, that helps organise DNA and turn off genes when not needed. Mutations in MORC2 cause Charcot-Marie-Tooth disease, a rare condition that weakens muscles. These findings could lead to new treatments. www.nature.com/articles/s41...

Relevant to projects focusing on effects of long term elevated heat.

Apologies in advance…

For those of you who may not have known him, Dr. Atul Butte, a pioneer in informatics, was the winner of the 2024 Morris F. Collen award, a pinnacle achievement in our field, as part of his storied career. His passing is a major loss to us all. RIP Dr. Butte #MedSky

Care it. ?

Random Reddit post whereupon J learned (1) click lighters generate a tiny EMP that can turn off a computer monitor, and (2) desk chair pistons can do the same 🤯 Will this become a feature of desk chairs? “Certified EMP-free” www.reddit.com/r/pcmasterra...

Again, reminder for American policymakers that return on investment is 2.5x for NIH funded research. Includes many short term benefits to cancer patients, and many medium term benefits broadly to health and quality of life. This research is not wasteful spending.

Senator Durbin noted that some (I believe Republican Senators) had indicated the US had been doing more than its share of biomedical research and it was time for other countries take a turn. I felt I had to interrupt to respond...

Random post, the comments are gold.

My “Step 2. Draw the rest of the owl” jokes might lose their edge if I could actually draw the rest of the owl like this! Very nice.

Thanks to everybody who chimed in! I arrived at the conclusion that (1) there's a lot of interesting stuff about interactions and (2) the figure I was looking for does not exist. So, I made it myself! Here's a simple illustration of how to control for confounding in interactions:>

Sweet!

I am excited to share a new version of svglite for #rstats with the world. It includes support for all the new features in the graphics engine as well as providing a more powerful and polished experience for embedding web fonts in the file. Read all about it her:

Another win for Justice Allison Riggs, this time in US District Court! Let’s hope Jefferson Griffin finally accepts his loss. (He has one week to appeal.) Source: bit.ly/4iRIqK5

A new R-4.5.0 function “grepv()” mimics a function I’ve used for years in jamba: vgrep(): value-returning grep and moreso vigrep(): case-insensitive value Okay I’m not the only one. 👀 Next up, version-type sorting? To order chromosomes chr1, chr2, … chr9, chr10

Well said. All ballot applications so far (30,000+) have had valid license or SSN on their application, not one has lacked info. The core issue is a coding glitch that “didn’t match” DMV/ID records, and simply stored “unverified.” Headlines calling it “a twist” are wildly misrepresenting the story.

Genomics yields biological and phenotypic insights into bipolar disorder rdcu.be/efkLZ

Great thread, I’m excited to dig deeper into this preprint. We’re facing similar challenges as well. Rough summary: The effects of using a human genome reference which is not fully representative of worldwide populations.

Minecraft keeps looking better and better.

👇THIS is who NIH/NIEHS is! Every day of every week, these scientists work to discover and develop life-saving meds and treatments that benefit us all. We should be proud of what the scientific community in NC has achieved. Let’s be more vocal about it, because he’s right, this touches every family.

It me 6-7 years of avoidance, haha. Iltimately not too bad, and the CRAN reviewers were great. Now I’m ready to push other jam packages to CRAN or Bioconductor. Let’s go.

This package looks great! Anything with color, to help my brain see the patterns.

Step 7 is key. Ideal world, nothing gets past step 7 even in the face of firings. The driver is federal responsibility to uphold the law. “Simply need confirmation of the legal aspects, until then my duty to the American people is to prevent access until it is legally clear.” Not personal of course.

I've seen three different articles on this, because the guy who owns the company that makes this stuff reached out to the press. He's got 400,000 boxes of life-saving goo sitting in a warehouse, and if USAID won't accept it, he's going to have to throw it out.

Desperately screaming: "Computer, exit" has thus far not yielded the desired result. I'm on trial 6,534. Will report back on results of additional trials.

A missing part of the indirects conversation: equipment and clinical care are not subject to indirects. The true indirect rate is ~27%. Explainer 👇

The summary: ~27% of total grant money goes to overhead, pretty consistently. Interesting question: When did it start, and why? It seems like NIH is complicit since they’re all still essentially 27%, what drove the policy?

Always great to follow CA2 research, I’m very keen to dive into this paper! Nice work!

Great read on the history of tidyverse. The *personal* history no less, haha. Amazing breadth of R packages owned or touched by Dr. Wickham and tidyverse community.

Wow, we’re still finding new brain regions? This region sounds particularly relevant to mental conditions beyond, say, bipolar, perhaps a model for understanding personality disorders.

Being a person with deadly, incurable cancer who is nonetheless still alive for an indefinite timeframe gives me an interesting metaphor that helps me deal with things like large-scale corruption in government or commerce. Bear with me for a second while I try to explain.

Thank you. It is cathartic (but also quite stressful) to think through these issues and unburden myself a bit.

As we start the new year, I would like to remind everyone that it is now almost 120 years since the US decided consumer protection - by which I mean regulation - mattered. Given the upcoming presidential inauguration, let's talk about how that happened - and why it's so important. (A thread)

Where would I find such a training? 👀 Amazing, would love to learn.

Time for a 🧵 on our new paper from the Walkley lab in @scienceimmuno.bsky.social. If you're into RNA editing by ADARs, double-stranded RNA (dsRNA) sensing, post-transcriptional gene regulation and CRISPR screening, then read on! 1/X www.science.org/doi/10.1126/... #RNASky #ImmunoSky

Because we don’t see enough real estate in historic Wales, especially of 16th century architecture. Plus, the bathroom was an indulgence, I’d love to know the backstory.

Hillary Clinton receiving the Presidential Medal of Freedom today. Perfection.

Math coincidences are wild. How many times does (1..n)^2 even equal 1^3+2^3+..n^3? Spoiler: Every time. Whoa.🤯 I hope 2025 is a great year for everyone!

Fun “playoff style” coding font game, I enjoyed it. March Madness is still a long way off. When bluesky adds polls, it would be fun to see the winner across like, the tidyverse user base or something huge.

Mentorship, influence, collegiality. One of my favorite courses at UNC “Case Studies in Structural and Molecular Biology”, taught by Charlie Carter, Mary-Ellen Jones, and Richard Wolfenden, followed the trajectory of major scientific discoveries. In what is now the ME Jones Building. Same energy.

I could read these all day, a wonderful summary of Dr Lubert Stryer’s life, a remarkably perfect person to have written a foundational Biochemistry textbook. These are amazing stories in science, this is what the inspired mind can do.