New MDCP Pearl: Computer Vision Analysis for Objective Motor Assessment in Parkinson's Disease: A Retrospective Study https://loom.ly/5kOko2o

Motor improvement ≠ life improvement. After STN-DBS, patients rated real-world functioning ~7.7/10—yet genetics (GBA) and sex tracked more with socio-occupational outcomes than the usual clinic scores. We need outcomes that reflect living, not just moving. https://loom.ly/JkeP8t4

Cervical dystonia has 2 big phenotypes: -Early onset (35y) = much worse pain/mood/QoL vs later onset (48y) — motor severity differences are smaller. -Don’t “BoNT-and-bye”: treat the non-motor load. https://loom.ly/C2cZIOc

PD & fractures: we’re missing the mark. Only 12% on bone protection pre-fracture → just 53% @48wks post-fracture. -Men, rib #, care home residents = least treated -Vertebral # drives treatment—but shouldn’t be the trigger -Think bone health EARLY in Parkinson’s https://loom.ly/CN43aPU

The Japanese anime character Naruto Uzumaki has for generations inspired children and adults. in this study Naruto's running style was observed and described in children and interpreted as a evidence of a cultural meme rather than a pathological disorder of movement. https://loom.ly/hclviEI

Continuous subcutaneous apomorphine infusion (CSAI) may benefit selected patients with multiple system atrophy. In a French multicenter cohort (n=50), CSAI improved motor symptoms in 90% at 6 months, with acceptable tolerability. #MSA #Parkinsons #DAT #Apomorphine https://loom.ly/BL2WFJo

Among PDRD patients with significant palliative needs, nearly half had an ED visit and one in five were hospitalized annually. Home-based services were used by over a third. Acute care use remains substantial underscoring gaps in supportive care delivery. https://loom.ly/ni_LYAc

Foslevodopa/foscarbidopa improves urinary disturbances, nocturia and quality of life in PD patients. Both overnight continuous dopaminergic stimulation and increasing the total dose of L-dopa contribute to improve overactive bladder. https://loom.ly/7apCuI8

The 'Swallow Tail Sign' gets an upgrade! Absence of dorsolateral nigral hyperintensity on SMWI is a robust, reproducible marker of neurodegenerative parkinsonism—works early, survives real‑world controls, and fits existing MRI pathways! https://loom.ly/VaFEiNw

MRgFUS thalamotomy shows strong tremor control even in patients ≥80 — with 95.6% improving and side‑effect rates similar to younger adults. Learning point: Age alone shouldn’t exclude MRgFUS; balance issues are common but usually improve or resolve. https://loom.ly/TaVJnSw

Two siblings with BCL11B‑related early‑onset dystonia showed striking, long‑lasting motor improvement after GPi‑DBS,with >50% BFMDRS-M reduction. A reminder that genetic dystonias can be highly DBS‑responsive—mutation type, phenotype & timing matter. https://loom.ly/jdqaE90

Exocrine dysfunction in PD is common & early—drooling, dry mouth/eyes, seborrhea, rhinorrhea, sweating & GI issues all reflect autonomic + α‑synuclein pathology. Clinician tip: Ask about these symptoms—they’re underrecognized but highly impactful! https://loom.ly/f8qhIg4

Subcutaneous foslevodopa/foscarbidopa (fLD/fCD) was thought to overcome systemic and nutritional complications of LCIG therapy, but peripheral neuropathy can still emerge. Baseline + ongoing vitamin & nerve monitoring recommended! https://loom.ly/ZhfwsWM

New scoping review highlights how FXTAS remains under diagnosed in Latin America. https://loom.ly/YRyRVdg

A global MDS member survey on career and work environment found pronounced gender disparities in the field. Data were proportionally representative of Pan-America, Asia-Oceania, Europe, and Africa. https://loom.ly/G1b2SQo

New case series:In PD dementia,cognitive fluctuations were consistently time‑locked to hypotensive episodes on 24‑hr BP monitoring — independent of levodopa timing. Recognizing & treating hypotension may be key to improving cognition. https://loom.ly/p938aJI

The Parkinson’s Pals program reduced loneliness and demoralization in pwPD after just 8 virtual sessions, while boosting student PD knowledge. Low‑cost, scalable psychosocial care in action! https://loom.ly/-dCdb0U

New MDCP Pearl: Digital Gait Measures Discriminate People with Friedreich's Ataxia from Healthy Controls https://loom.ly/WPtnCjQ

Long-term data from 31 orthostatic tremor patients show that about half continued perampanel, experiencing better social functioning, mental health, and reduced pain. Benefits are meaningful, but side effects remain frequent and may outweigh the benefit in some OT patients. https://loom.ly/pz6jNwg

Can we identify patients at risk for a first fall before it occurs? Using routinely collected motor and cognitive data from clinic visits, we developed and validated a model to estimate first-fall risk in Parkinson’s disease, supporting earlier, proactive clinical assessment. https://loom.ly/-7dF36k

Extensive hemispheric vasogenic edema after MRgFUS thalamotomy for essential tremor — first report! Takeaway for clinicians: remain vigilant for delayed neurological decline post‑MRgFUS & manage promptly. https://loom.ly/GOIJapc

High dairy intake = ↑ PD risk in men (but not women), but evidence is weak + observational only. No basis for advising dairy restriction. Mechanisms unclear (pesticides? uric acid? hormones). Useful reminder: association ≠ causation. https://loom.ly/f1RjCKE

New insights for DBS teams: PD patients awaiting STN‑DBS often show less active & more emotion‑focused coping, which correlates with ↑ anxiety, depression, psychosomatic symptoms & ↓ QoL. Poor executive function = fewer adaptive coping strategies. https://loom.ly/ZAKrvmQ

When should you switch off DBS in late‑stage Parkinson’s? This study of 25 LSPD patients shows some stay stable on meds alone, but 40% need rapid rescue therapy—especially those with <10.5 yrs of DBS. https://loom.ly/eCRCTUI

Pump therapies in PD aren’t the slam‑dunk we think. SC foslevodopa–foscarbidopa: 1 in 3 quit in 4 weeks—mostly by choice, not side effects. Big lesson: motor gains ≠ patient satisfaction. https://loom.ly/HtLmQSs

Dominant HSP isn’t one disease — and this MDSGene mega‑review proves it. Across 2,177 cases, ATL1, SPAST & REEP1 show strikingly different ages at onset, phenotypic signatures & variant biology. https://loom.ly/oPbBHBI

New MDCP Pearl: Using a Brief Body Sway Assessment Device to Track Balance Differences across the Huntington's Disease Integrated Staging System Spectrum. https://loom.ly/7CZFC68

New MDCP Pearl: Prognostic Value of Parkinson's Disease Subtypes in the LABS-PD Cohort: Functional Ability, Quality of Life and Mortality. https://doi.org/10.1002/mdc3.70412

Significant weight loss in PD isn’t “expected ageing” — it’s a progression alarm. In COPPADIS, >10% loss was 2× more common in PwP and flagged worse motor complications, mood decline, dysphagia, cognitive drop‑off & major QoL hit. https://loom.ly/bYwVYH8

Chronic watery diarrhoea in a patient on oral levodopa/DDCI-think microscopic colitis! This under‑recognised, drug‑associated complication typically resolve after discontinuing or switching the DDCI,or switching to an alternative treatment such as s/c Foslevodopa/Foscarbidopa https://loom.ly/b0uW2iM

Sex hormones shape PD. Clinical tip: Always ask about reproductive history + hormonal milestones https://loom.ly/w3RfMag

Charcot at 200 This new review revisits how Charcot shaped modern neurology—defining Parkinson’s disease, distinguishing tremors, describing ALS, and founding the blueprint for today’s academic neuro centers through his anatomo‑clinical method and visual documentation. https://loom.ly/0cZ67tM

Hospitalized PD patient with sudden rigidity, confusion, or fever? Think acute dopamine depletion. In this Mayo series, triggers included levodopa withdrawal (27%), antidopaminergics (33%), sepsis ± withdrawal (34%), and DBS failure. https://loom.ly/bdYDTXw

In myoclonus–dystonia (SGCE), impaired convergence—with preserved divergence—provides a clean, pathway‑specific signature of dorsal vermis Purkinje cell dysfunction, offering a simple oculomotor clue to cerebellar involvement. https://loom.ly/yyip2ZQ

Stimulants in cerebellar ataxia? 🧠 In this patient‑reported study, alertness (95%), fatigue (90%), and executive function (80%) all improved with stimulant therapy—supported by a 26% improvement in PROM‑Ataxia Mental scores. https://loom.ly/ewaQWhc

STN‑DBS improves motor function but ~50% of patients feel their communication gets worse, even when language & cognition tests stay stable. Remember: use CPIB, counsel early about speech risks, and assess motor speech + mood—not just fluency scores. https://loom.ly/RBZlks4

For people with Parkinson’s, quality of life is personal, adaptable, and shaped by what supports their well-being. Health can help or hinder it. Listening to these perspectives can improve care, interventions, and how we measure what truly matters. https://loom.ly/H4PJcTU

New MDCP Pearl: Prognostic Value of Parkinson's Disease Subtypes in the LABS-PD Cohort: Functional Ability, Quality of Life and Mortality. https://loom.ly/yEAIZ68

"Listen, the patient is telling you the diagnosis." Voice and speech changes are common in atypical Parkinsonian disorders. However, evaluating and treating them can be challenging. This review aims to provide clinicians with a practical guideline to improve patient care. https://loom.ly/URAjhlA

Our new systematic review and network meta-analysis shows that rasagiline may modestly improve global cognitive performance in Parkinson’s disease, while MAO-B inhibitors overall show limited effects on specific cognitive domains. https://loom.ly/YANW3BY

Is Early Oophorectomy a Hidden Parkinson’s Risk? Systematic review shows 32% higher PD risk after premenopausal bilateral oophorectomy, with hints of greater risk at younger ages. Even hysterectomy with ovarian conservation isn’t risk-free. https://loom.ly/4GFiRIs

Features emphasized in phase 1 development of the @movedisorder.bsky.social PD e-Diary included sensitivity to change, customizable or predefined item banks, personal and research modes, and feedback reports. #COA https://loom.ly/-xuzyqQ

Tongue movement disorders can be subtle, varied, hard to classify, (and missed!) yet offer important diagnostic clues. Our review outlines a clinical framework for tongue MDs. https://loom.ly/6_glCDQ

João Moura and colleagues recently published a global overview of movement disorders associated with specific ethnic or geographic backgrounds. https://loom.ly/z8SNUK4

New MDCP Pearl: Levodopa-Carbidopa Intestinal Gel Improves Dyskinesia in Parkinson's Disease: Post Hoc Analysis from the COSMOS Study https://loom.ly/vSxgyuk

In a 248-patient study—largest to date—we show SMWI detects loss of dorsolateral nigral hyperintensity ("swallow tail sign") with 92%SN, 96%SP, and κ=0.88 for degenerative parkinsonism. https://loom.ly/VaFEiNw

MDS Tourette Syndrome Study Group found no compelling evidence to make general clinical recommendations on complementary medicine for TS. Rather, they advise knowledge gap transparency when engaging patients about specific treatments. https://loom.ly/mMBjYSw

Could DBS reshape the brain beyond symptom control? Neuroimaging shows: -Increased STN activity -Mixed connectivity shifts in motor & non-motor networks -Hippocampal atrophy—aging or DBS effect?What does this mean for long-term cognition? What are the implication? Read more: https://loom.ly/AmBkTOs

Menstrual cycle & pregnancy matter in Parkinsons! 60% of women with early-onset PD report perimenstrual worsening; 40% experience symptom changes during pregnancy/postpartum. An unmet need for tailored guidelines! An unmet need for tailored guidelines! https://loom.ly/Gcn02nA

New MDCP Pearl: Orthostatic Tremor Is Evoked by Muscle Load Without the Need for Orthostatic Position https://loom.ly/fLM3XHw