Prenatal exposure to #acetaminophen was not associated with an increased risk of #autism in offspring in a large Danish cohort, with consistent findings in population and sibling analyses. ja.ma/4tPlQrr

Annual prevalence of unmet health care needs among children with #AutismSpectrumDisorder in the US doubled from 2016 to 2023, with sharp postpandemic increases in unmet mental and medical health care needs. ja.ma/3OcjHXu

Assigned female at birth youth in Medicaid and CHIP had higher rates of hormone therapy and puberty blocker use than assigned male at birth youth, with lower overall gender-related care utilization compared to commercially insured adolescents. ja.ma/3PH2G8a

Among US patients with #SpinalMuscularAtrophy, #GeneTherapy was associated with low out-of-pocket costs relative to total spending, but costs varied by insurance plan type and treatment type. ja.ma/3Qge23k

EEG-guided anesthesia was associated with a lower incidence of emergence delirium, reduced pediatric anesthesia emergence delirium scores, and shorter postanesthesia care unit stays among children compared with standard practice. ja.ma/4vO6Sno

Children with metabolically healthy obesity had higher risk of type 2 diabetes, hypertension, and dyslipidemia as young adults vs the general population. Obesity treatment lowered risk in all groups. ja.ma/4c8bzPR

Nirsevimab immunization was cost saving and reduced #RSV-related hospitalizations in most Italian pediatric centers, with the greatest benefits observed when campaigns started before the epidemic season. ja.ma/4cGODZn

Wearables indicate six sleep health dimensions in young adolescents. Sleep irregularity and shorter duration were associated with transdiagnostic mental health symptoms. ja.ma/4tqkALc

The CONSORT–Children and Adolescents (CONSORT-C) 2026 guideline extends CONSORT 2025 with 13 new reporting items for pediatric RCTs, enhancing transparency, reproducibility, and relevance for patients aged 0 to 19 years. ja.ma/4cpj9FX

Meta-analysis: Cognitive and educational disadvantages after #PretermBirth or low birth weight persist through the life course, particularly for those born before 28 weeks or with birth weight <1.0 kg. ja.ma/4trWHTe

💬Editorial: Economic analyses indicate that nirsevimab immunization can be cost saving in real-world settings, but the extent of cost-effectiveness varies with health system resources, cost drivers, and analytic perspective across countries. ja.ma/4sAsD7o

Exposure to alcohol-promoting #SocialMedia content increased desire to drink among young adults, supporting concerns about online influencer content and its influence on alcohol-related attitudes. ja.ma/4sBJ2bw

Parents of children with #NeurodevelopmentalDisorders—including autism, ADHD, or intellectual disability—had a higher risk of developing #CardiovascularDisease, especially with multiple affected children or comorbidities. ja.ma/4sxFnvp

Uncompensated hospitalizations comprised 3.4% of encounters and 3% of costs in US children’s hospitals, with most nonreimbursed stays involving lower complexity and shorter length of stay. ja.ma/4cuvSHw

All current World Health Organization IMCI algorithm clinical signs were associated with mortality or culture-confirmed sepsis, and additional signs such as prolonged capillary refill and central cyanosis may improve risk identification in young infants. ja.ma/4c7h2rh

Buprenorphine and medications for #ADHD are frequently implicated in emergency department visits and hospitalizations for unintentional oral prescription medication exposures among children younger than 6 years. ja.ma/4rLXmO9

Among extremely preterm infants, prophylactic acetaminophen for patent ductus arteriosus accelerated ductal closure but did not increase survival without severe neonatal morbidity at 36 weeks and was associated with higher rates of cholestasis. ja.ma/4cglsei

Wearables indicate six sleep health dimensions in young adolescents. Sleep irregularity and shorter duration were associated with transdiagnostic mental health symptoms. ja.ma/4drn9I8

Meta-analysis: Cognitive and educational disadvantages after #PretermBirth or low birth weight persist through the life course, particularly for those born before 28 weeks or with birth weight <1.0 kg. ja.ma/4cbqf0v

Regulatory changes have expanded #Naloxone and #Buprenorphine access, but adolescents remain under-treated for opioid overdose and use disorder despite persistently high overdose fatalities. ja.ma/4rT79Ck

Children with metabolically healthy obesity had higher risk of type 2 diabetes, hypertension, and dyslipidemia as young adults vs the general population. Obesity treatment lowered risk in all groups. ja.ma/3PJuPf2

Among children 5 to 9 years, suicide deaths were rare but present in 30 countries, most involving hanging or suffocation, and were more frequent among boys, supporting prevention focused on environmental safety. ja.ma/4sTf9Eu

Annual prevalence of unmet health care needs among children with #AutismSpectrumDisorder in the US doubled from 2016 to 2023, with sharp postpandemic increases in unmet mental and medical health care needs. ja.ma/4s7zq8f

A parent-led developmental intervention improved executive function at school age in preterm children, especially in disadvantaged settings, supporting early, home-based approaches for neurodevelopment. ja.ma/3PJCGsR

In a national survey, children with developmental disabilities had over twice the prevalence of parent-reported #ChronicPain compared with children without disabilities. Socioeconomic and adversity factors further increased risk. ja.ma/41lVVLQ

Uncompensated hospitalizations comprised 3.4% of encounters and 3% of costs in US children’s hospitals, with most nonreimbursed stays involving lower complexity and shorter length of stay. ja.ma/48wdP2a

Parent-led early intervention in very preterm infants improved executive function at school age compared with usual care, supporting long-term neurodevelopmental benefits for #Preterm children. ja.ma/3PH9q5X

PrEP uptake among US youths aged 13-21 with HIV indications was low, with higher initiation in older males and states with LGBTQ+ protections, and lower rates among females, minors, and those in the South. ja.ma/3Ok25Jm

💬 Editorial: Observational data suggest an ICP threshold around 14-15 mm Hg better predicts outcome than 20 mm Hg in pediatric #TBI, supporting developmentally appropriate management strategies. ja.ma/4sqVKKk

Sustained intracranial pressure >14-15 mm Hg in children with moderate to severe #TBI was associated with poorer long-term functional outcomes, indicating current 20 mm Hg thresholds may be too high. ja.ma/4toPzXS

Children with metabolically healthy obesity had higher risk of type 2 diabetes, hypertension, and dyslipidemia as young adults vs the general population. Obesity treatment lowered risk in all groups. ja.ma/4c4UAO9

Wearables indicate six sleep health dimensions in young adolescents. Sleep irregularity and shorter duration were associated with transdiagnostic mental health symptoms. ja.ma/3PPr4oe

This JAMA Pediatrics Patient Page describes moles in children, including when children should see a skin specialist for evaluation. ja.ma/4dS4J3h

Annual prevalence of unmet health care needs among children with #AutismSpectrumDisorder in the US doubled from 2016 to 2023, with sharp postpandemic increases in unmet mental and medical health care needs. ja.ma/4bJMzQ3

Meta-analysis: Cognitive and educational disadvantages after #PretermBirth or low birth weight persist through the life course, particularly for those born before 28 weeks or with birth weight <1.0 kg. ja.ma/410pWAC

In a national survey, children with developmental disabilities had over twice the prevalence of parent-reported #ChronicPain compared with children without disabilities. Socioeconomic and adversity factors further increased risk. ja.ma/4uY8vOO

📊 JAMA Clinical Guidelines Synopsis: The 2026 #PediatricSepsis guidelines by SCCM and ESICM recommend immediate antimicrobial therapy for suspected septic shock and timely blood lactate measurement for all children with sepsis. ja.ma/4ca2NSu

💬 Editorial: Plasma levels of glial fibrillary acid protein and neurofilament light chain increased before acute brain injury diagnosis during pediatric ECMO and were associated with unfavorable outcomes. ja.ma/4rYELyA

Hospitalizations for eating disorders among adolescents and young adults rose after COVID-19 onset and returned to prepandemic levels five years later. ja.ma/3PqG242

Children with metabolically healthy obesity had higher risk of type 2 diabetes, hypertension, and dyslipidemia as young adults vs the general population. Obesity treatment lowered risk in all groups. ja.ma/4uJTNuB

Wearables indicate six sleep health dimensions in young adolescents. Sleep irregularity and shorter duration were associated with transdiagnostic mental health symptoms. ja.ma/41vRFsU

From @jama.com: Among US #pediatric hospitalizations, an electronic health record–based definition identified #sepsis in 1.3% of encounters, with an in-hospital mortality rate of 10%. #SCCM2026 #CriticalCare @sccmcriticalcare.bsky.social ja.ma/4rSUBuB

💬 Editorial: Use of high-performance valved holding chambers (#VHC) for pressurized metered-dose inhaler delivery substantially improves clinical outcomes for young children with acute #asthma exacerbations, including reduced hospitalization. ja.ma/4bNYaNI

💬 Editorial: Nighttime #ScreenUse is consistently linked to later sleep onset and poorer sleep quality among youth, with repeated within-person studies confirming direct associations between evening phone use and sleep disruption. ja.ma/4rJ45bL

Among sexually active adolescents in a large pediatric network, 12% had not received any #HPV vaccine before sexual debut, with higher rates among non-Hispanic White and commercially insured patients. ja.ma/3Nz2WFw

Among children with chronic kidney disease, first-line #RAASi were associated with lower risk of CKD progression and improved blood pressure control compared to #CCB. ja.ma/4dslbaj

In 2025, JAMA Pediatrics remained the highest-ranked pediatric journal, with >3,300 manuscript submissions, an Impact Factor of 18, and >12.9 million article views. Read the full “Year in Review, 2025,” by Editor in Chief Dimitri A. Christakis, MD, MPH. ja.ma/4bhqvfp

💬 Editorial: Social policies such as universal pre-kindergarten (#UPK), income supports, food and housing programs are associated with reduced child neglect, especially in disadvantaged populations. ja.ma/4lx8NIh

Annual prevalence of unmet health care needs among children with #AutismSpectrumDisorder in the US doubled from 2016 to 2023, with sharp postpandemic increases in unmet mental and medical health care needs. ja.ma/4buO9Ui

From 2022 to 2025, #ChildPoverty rates declined in most US counties, but Black and Hispanic children continued to face higher rates than White children. ja.ma/4drqzdH