Can we measure & shift a cell’s age? Meet Pasta, a plug-and-play transcriptomic clock that flags perturbations that ↑ (cancer therapy) or ↓ (regenerative medicine) biological age. doi.org/pqhh bsky.app/profile/jero...

Can we measure & shift a cell’s age? Meet Pasta, a plug-and-play transcriptomic clock that flags perturbations that ↑ (cancer therapy) or ↓ (regenerative medicine) biological age. doi.org/pqhh #aging #AI 🧵 bsky.app/profile/jero...

Can we measure & shift a cell’s age? Meet Pasta, a plug-and-play transcriptomic clock that flags perturbations that ↑ (cancer therapy) or ↓ (regenerative medicine) biological age. doi.org/pqhh #aging #AI 🧵 bsky.app/profile/jero...

Can we measure & shift a cell’s age? Meet Pasta, a plug-and-play transcriptomic clock that flags perturbations that ↑ (cancer therapy) or ↓ (regenerative medicine) biological age. doi.org/pqhh #aging #AI 🧵👇

🚨 Pre-print alert! 🚨 We generated chromosome-scale diploid genome assemblies for the widely used fibroblast lines BJ and IMR-90. These models of replicative senescence and telomere shortening now have fully resolved telomeres, subtelomeres, and centromeres. 🧬 🧵👇

Emerging insights in senescence: pathways from preclinical models to therapeutic innovations 👩‍🔬🧪🔬🥼👨‍🔬 #senescence #SASP #ageing #inflammation #NephSky #CardioSky #Senescent Full details 👇 ✨️ www.nature.com/articles/s41...