HIV-1 subtype C: 59.3%. High resistance: 3TC/FTC 88.3%, EFV 92.8%, NVP 96.8%. M184V/I in 86.2%, K103N in 57.8%, more in Africa/S.America (p<0.05).##idsky

IT-aided audit in Urology cut restricted antibiotic use by ~50%, boosted Access group drugs, and improved guideline adherence for UTIs, but long-term change is tough.💊📉##idsky

In 214 flu episodes among 143 allo-HCT pts, vax cut LRTD risk by 82% (HR 0.18) & hosp by 80% (OR 0.20). High ISI ↑ LRTD (HR 4.71) & hosp (OR 22.86). 🦠💉##idsky

RSV cases (n=8457) in Dutch kids <2y showed a shift from 2.2 to 4.9 months median age during COVID, returning to 2.7 months by 2023/24. Seasonality reverted to pre-COVID winter pattern.❄️📈##idsky

11,082 PWH studied; anti-HBs <100 IU/L cleared faster. Peak anti-HBs 100–499 IU/L (HR 0.26), 500–999 (HR 0.17), ≥1000 (HR 0.10) protect vs clearance.💉##idsky

TAF twice-daily with rifampicin ↑TFV-DP by 32%, safe+efficacious; 95% viral suppression in 43 HIV/TB pts. No serious AEs/discontinuations. Supports TAF use in TB/HIV 🦠💊##idsky

Study of 3694 cases found fever in 78% cases, similar in IE/non-IE. Excluding fever ↑sensitivity 74→77% & specificity 49→80% for IE diagnosis in 2023 Duke-ISCVID criteria.⚕️##idsky

JoRRP incidence: 3.82/100K live births; prevalence: 4.17/100K. 50% had aggressive disease. Diagnosis ≤2 yrs ↑aggressive risk (OR ~0.3-0.43). Maternal HIV linked to lung involvement.🦠👶##idsky

MucorGenius® PCR detected Mucorales DNA in 28% samples, with 94.4% sensitivity for mucormycosis. It identified co-infections and 11 cases missed by routine tests.🦠🔬##idsky

mNGS cut diagnosis time by ~145 days, 88 tests, 2 LPs in DNA viral cases; 144 days, 30 tests, 12 LPs in bacterial; 297 days, 126 tests, 2 LPs in autoimmune cases🧠📉##idsky

Study found FTC detected in 53.3% oral fluids ≤48h post-dose; FTC <7.5ng/mL predicts non-adherence with 90% sensitivity, 65% specificity. TFV detection too low (9.0%). 💊👄##idsky

Study shows 🏥 caregiving sheds Candida auris rapidly; 80%🔽 with chlorhexidine gluconate ≥156 µg/mL. High-contact care = key spread; chlorhexidine aids risk cut in LTC.##idsky

NSTIs require urgent surgery+antibiotics. Shorter antibiotic courses post-surgery are effective, even with streptococcal bacteremia. Clindamycin use faces resistance; linezolid is a safe alternative. ⚔️🦠⏳##idsky

AI in infectious diseases (ID) can boost care through automation, but 100% AI literacy is vital for clinicians to lead, ensure quality data, oversight, and shape AI use in practice.🤖📈##idsky

HRV found in 4.6% (437/9,544) hospitalized adults; 49% had co-infections. HRV pneumonia in 7.8%. Male, fever, cough predict HRV pneumonia; 61.5% show LRT infection via IF.🦠##idsky

Acute HCV triggers a strong interferon-driven NK cell activation. DAAs cure it, removing activated NK cells, but long-term changes vs. healthy controls remain. 🔬🦠✨##idsky

Babesia microti, a tick disease, affects US blood donors. 🦠 14 states screen donors since 2019. Experts advise retest, observe asymptomatic cases; treat only if smear positive. 🩸##idsky

RSV-ARI pts≥50 had 10.77x⬆ mortality risk0-30d vs controls; MI, asthma, COPD, HF risks⬆ too. RSV-ARI & influenza-ARI had similar outcomes. Data: 14.7K RSV, 77.5K flu, 73.8K controls.📊##idsky

7.4% of HBV/HIV pts in China had HDV; 22.6% were HDV RNA+. HDV RNA dropped 92.8% after 7 yrs ART. HDV didn't affect HIV/HBV treatment or liver disease risk.📉🦠##idsky

Prof. Harbarth, an expert in antibiotic resistance, leads infection control at HUG, won the 2022 Robert Koch Award, and headed EU projects with 20+ partners in 12 countries. 🦠🏥🌍##idsky

Fungal surveillance in 12 countries (n=15 centers) is varied and underfunded, causing inconsistent data. Authors urge better integration and standardization for antifungal resistance tracking. 🦠📊##idsky

Ethiopia study: CAD4TB sensitivity 77%🤖, specificity 93%; stool Xpert sensitivity 77%, specificity 97%, κ=0.76. 10.6% HHCs had new TB. Combo aids TB detection, esp. kids & sputum-challenged.##idsky

Lenacapavir biannual HIV drug showed 61% virus suppression at wk 156; CD4 ↑ 164 cells/μL; 14/72 got resistance; low side effects; 2 stopped due to nodules.🦠💉##idsky

RZV vax 💉 in 102,766 adults ≥50↓ risk of HZO by 72.9%, hospitalized AMI by 28%, stroke by 42% vs 411,064 unvax. Median age 68, 59%♀, 57.1% NH White.##idsky

Review explains hierarchical composite end points (HCEs) in infectious disease research, detailing 4 analysis methods: Wilcoxon rank sum, pairwise comparisons, proportional odds, probabilistic index.📊##idsky

20.4% of <5y kids exposed to MDR-TB had TB infection. Risks: longer cough, drug misuse in adult, child's age, relation to adult, study site. Improved MDR-TB care may lower rates.🦠👶##idsky

561 pregnant women studied for CMV; transmission without treatment: low avidity 31-34%, intermediate 14-22%. Valacyclovir cut transmission to 2-16% by timing. 🎯🦠##idsky

CDC 2021 HIV PrEP guidelines ↑RNA testing rate 16→123/100 person-yrs🧪; RNA positivity↓1.39%→0.22%; RNA PPV↓100%→67%. ~8,226-9,900 RNA tests needed per early HIV diagnosis🦠.##idsky

FMGX showed a 25% mortality @Day 42 & 40% success rate in IMDs pts (n=20, age~62). 15/21 had related AEs; 3 stopped tx. Safety 🤝 high-risk pts; supports further FMGX use.##idsky

Author says Milwaukee Protocol's demise is exaggerated; 18 lab-confirmed rabies survivors reported by "inexperienced clinicians," unlike Dr. Jackson's no-survivor reports.🧪🦠##idsky

CVST occurred in 5.6% of cryptococcal meningitis (CM) patients🧠. No thrombophilia genes found, but 44 thrombosis genes were elevated🧬. MRI/MRV aids diagnosis🩻.##idsky

Author says Milwaukee Protocol's demise is exaggerated; 18 lab-confirmed rabies survivors reported by "inexperienced clinicians," unlike Dr. Jackson's no-survivor reports.🧪🦠##idsky

AMBITION-cm showed promise for HIV+ cryptococcal meningitis using 10 mg/kg amphotericin B combo. Caution urged for non-HIV organ transplant pts due to immune variability & risks. ⚠️🧬##idsky

225 babesiosis pts studied; ICAH pts (112) had ↑parasitemia 2.8% vs 0.9%, AKI 24% vs 11%, ARDS 11% vs 4%, longer tx (27 vs 10 days), mortality 7% vs 1%🔴##idsky

HCV reinfection in incarcerated on MOUD: injection drug use & unsterile tattooing 3.4x risk, meth use 2.5x; younger age & poor buprenorphine adherence raise risk. 💉🔥##idsky

48,343 HIV+ with 2+ yrs virological suppression showed 1933 cancers (IR 6.43/1000 PY). Higher CD4↓cancer risk: IRR 0.26 at ≥750 cells/μL vs <350 (p<.0001). Early ART crucial.🦠🎗️##idsky

First study of A-to-I RNA editing in pathogenic bacteria found dozens of sites; E. coli shows higher edits than P. aeruginosa, mainly causing amino acid changes (e.g., Tyr-to-Cys)🧬##idsky

Early cmDNA PCR diagnosis in invasive wound mucormycosis cut 100-day mortality from 63.6%➡️30.8% (P=0.071), significantly better for TBSA≥30% (P=0.047).⏳🩺##idsky

Live-virus vaccines ↑ positive IGRA (4.6% vs 3.3-3.5%, OR≈1.27) & TST (15.7% vs 6.6-7.2%, OR≈2.4-3.8) in kids 2-14, challenging delay in TB testing 🧒💉🦠##idsky

Mycoplasma phocimorsus, ID'd in 2023 from 6 Scandinavian seal finger cases🦦, also found in US, Canada, Antarctica, Greenland. Antibiotics doxycycline+moxifloxacin used simultaneously💊.##idsky

Study: No significant difference in severe AKI risk with cefepime vs piperacillin-tazobactam in septic shock patients, aiding antibiotic nephrotoxicity debate 🦠🩺##idsky

Author clarifies moxifloxacin & doxycycline were given together; Mycoplasma phocacerebrale linked to seal finger in 1991, Mycoplasma phocimorsus in 2023. 🌍Seal finger rare outside N. regions.##idsky

mcfDNA seq: 47.7% sens, 100% spec for IFD dx. Aspergillus 70.8%, Mucorales 10.8%. Sens higher in proven IFD (60%) & mucormycosis (100%) vs aspergillosis (45.7%).🧬##idsky

Histoplasma antigenuria was found in 24.3% of advanced HIV pts in Côte d'Ivoire; 35.7% prevalence in those who died vs 22.3% survivors. It may cause preventable deaths.🦠💉##idsky

3 yrs post-PCV13+PPSV23, seroprotection dropped: 9% PWH, 17% immunosuppressed, 42% controls. Recall responses: 40% PWH, 14-22% immunosuppressed, 67% controls.🦠🔬##idsky

34F w/ liver transplant & leukemia presented w/ leg edema, dyspnea, pustules. CT: lung necrosis, lymph node 3.8cm. Biopsy: filamentous organisms; stains mostly neg. Immunosuppressed.##idsky

Viral-first HCV testing saves $0.26/person (intervention 1) or costs $8.60-$21.48 more (interventions 2 & 3) with more diagnoses & QALYs vs current US strategy.💉💰📈##idsky

TPT + effective ART cut TB by 87% (IR 0.55 vs 1.06/100 PY) & deaths by 94% (MR 2.2 vs 13.5/100 PY) in 4706 PWH over 6 yrs in India 🇮🇳🔥 #EndTB##idsky

Xpert-HR showed 88.5% sens⚡ but low spec (~30%) for TB in 181 kids (14.4% confirmed). Sens higher in ≥5 yrs; combining tests didn't boost accuracy. More pediatric markers needed.🧒🩸##idsky

8 Oregon residents got Mycobacterium immunogenum infections from tattoos by 1 artist; ink likely contaminated by self-made diluent. Reporting 🔍 needed for outbreak control.##idsky