🎥 A glimpse into our 7-day directed differentiation of human iPSC-derived dorsal horn neurons. Fast. Reproducible. Ready for pain pathway discovery. #NotYourAverageNeuron #CompleteTheCircuit #neuroscience #drugdiscovery #iPSC #dorsalhorn #painresearch

Motor neurons alone can't explain ALS or CMT. Schwann Cell Precursors reveal how disrupted glial-neuronal crosstalk drives disease. Co-cultures model early pathogenesis, glial dysfunction, and myelination defects more accurately. #CompleteTheCircuit #NotYourAverageNeuron

💡 Unlike chemo drugs that damage DNA, Bortezomib disrupts mitochondrial function and protein balance in nerves. RealDRG™ hiPSC-derived sensory neurons show dose-dependent cytotoxicity to Bortezomib—highlighting their value for CIPN research. #CIPN #PainResearch #RealDRG #DrugDiscovery

Add These Publications to Your Reading List 📚 Explore all publications featuring Anatomic’s products in one place — a fast way to find relevant assays and new applications. See how our models are advancing discovery: www.anatomic.com/publications #CompleteTheCircuit #NotYourAverageNeuron

The Kolber Lab at UTD has launched a core facility with a high-content analgesic screening assay using the Axion Maestro Pro, now featured in their latest publication. Read the article here: www.cell.com/cell-reports...

Team Anatomic hit the pavement together for the #Walk4CMT 💙 Grateful to be part of a community that's raising awareness, showing support, and walking toward a cure. Huge thanks to everyone who came out and walked with us and to CMTA for putting on a well organized and meaningful event.

Exciting synaptic insights! 🟢 Using Anatomic’s nociceptors & dorsal horn neurons, VGLUT2 (green) shows glutamate at synapses, while TUJ1 (red) highlights neurons. #CompleteTheCircuit #SensoryNeurons #PainResearch #DorsalHornNeurons #NotYourAverageNeuron

Keepin’ it local🤙🏼We attended the 3rd Minnesota Organoid Symposium put on by the University of Minnesota and Mayo Clinic earlier this week. Big shoutout to our Scitech intern Devanshi, who gave her first poster presentation! #NotYourAverageNeuron #CIPN #StemCells

🌉 Hello, San Francisco! Catch Vincent Truong at the Axion BioSystems World Tour on April 17! He’ll share how advanced hiPSC-based models are transforming #pain, #ALS & #CMT research. 🔗 Register now → axionbiosystems.com/axion-world-... #AxionWorldTour #hiPSC #Neuroscience #NotYourAverageNeuron

💡 Integrating Schwann cell precursors (SCPs) into motor neuron (MN) cultures enhances relevance by replicating human physiology. As SCPs mature, they migrate and align along axons, visualized via S100b/SOX10 (SCPs) and TUJ1 (MNs) staining. #CompleteTheCircuit #NotYourAverageNeuron #ALSResearch

Anatomic has been focused on developing CIPN-related assays for the last few years. The FDA’s new draft guidance underscores the need for better study designs and endpoints in CIPN research. Read the full guidance below! #CompleteTheCircuit #CIPNResearch

💎Check-out the purity💎 Images of co-cultures of RealSCP, hiPSC-derived Schwann cell precursors, and RealDRG, hiPSC-derived sensory neurons, generated without the need for genetic engineering or Mitomycin C. #CompleteTheCircuit #NotYourAverageNeuron

It’s always tough to pick favorites when there’s so much exciting data to explore! 🤩 We have compiled our favorite data from over the years onto a new page for your easy access. Check out our data highlights page at www.anatomic.com/datahighlights #CompleteTheCircuit #NotYourAverageNeuron

Harnessing a more physiological in vitro model for CIPN! Dr. Nanna Elman Andersen’s Ph.D. thesis explores chemotherapy-induced neurotoxicity using hiPSC-derived Schwann cells & sensory neurons, studying paclitaxel, vincristine & bortezomib. Read more: portal.findresearcher.sdu.dk/en/publicati...

Science is serious stuff, but sometimes it can’t help but make you smile. Especially when it smiles first 😁

🧒🏻👧🏽👦🏼👩🏽‍🦱Multiple donors. Same process. Sensory neurons derived from hiPSC lines (both healthy and diseased) express key ion channel targets for pain - NaV1.7, NaV1.8, and TRPV1. #NotYourAverageNeuron #CompleteTheCircuit #DiseaseModeling #PainResearch

🚨 New Insights into Chronic Pain 🚨 Reduced KCC2 expression in the dorsal horn links to chronic pain and opioid use. KCC2 regulates chloride gradients for inhibition, and its dysfunction drives neuropathic pain. Findings support therapies targeting KCC2. Read more: www.biorxiv.org/content/10.1...

💡 Paclitaxel, first FDA-approved in 1992 for ovarian cancer, is linked to chemotherapy-induced peripheral neuropathy (CIPN). Imaging shows dose-dependent cytotoxicity in sensory neurons & Schwann cell precursors, with co-cultures altering responses. #CompleteTheCircuit #CIPN #PainResearch

🔎How do you “spot” a melanocyte? You look with your naked eye! With RealMELO, Anatomic is going MACROSCOPIC! If your drug screen readout is pigmentation, the effects will be obvious in as little as 7 days post-thaw! #CompleteTheCircuit #Vitiligo #Melanoma #Cosmetics

📰RealDRG iPSC-derived nociceptors power a novel axonal electrophysiology platform! Using MaxWell Biosystems HD-MEAs + PDMS microstructures, this system aids nociceptor distinction & drug screening for neuropathic pain 🔗 Read more: www.biorxiv.org/content/10.1... #Pain #TRPV1

Sensory neurons and Schwann cells are better together❣️ Whether you are single or have date night plans, this is a scientific love story that you can study this Valentine’s day. #CompleteTheCircuit #NotYourAverageNeuron #PainResearch #CoCultures #CMT

🔬👩‍🔬Twitch isn’t only for gamers. See motor neuron-induced myofiber contraction in our neuromuscular junction (NMJ) assay using Anatomic’s new RealMOTO hiPSC-derived motor neurons! Industry-leading directed differentiation speed resulting in industry leading purity! #ALS #CMT #Microfluidics

CIPN is a major challenge in oncology, often limiting treatment. Using RealDRG™ hiPSC sensory neurons, we tested CIPN-related compounds and found that DSRM-3716, a SARM1 NADase inhibitor, preserves axonal density after bortezomib treatment. More studies underway! #StemCells #CIPN #Pain

Motor neurons 🤝 Schwann cell precursors Adding SCPs enhances ALS models by increasing physiological relevance. As co-cultures mature, SCPs align with axons—the first step of myelination! Learn more: [email protected] #CompleteTheCircuit #NotYourAverageNeuron

#SLAS2025 ✅ Kicking off the year with exciting progress! We shared our latest work on Schwann cell integration into our CIPN sensory neuron model, along with advancements in other cell types. Great discussions, collaborations, and insights—let’s keep the momentum going! #CompleteTheCircuit

🔗 Decoding Motor-Schwann Interactions! 🔬 ICC reveals neuron morphology & Schwann cell distribution, while qPCR tracks myelination markers over time. Schedule a call to learn more! #CompleteTheCircuit #PainResearch #NotYourAverageNeuron

🔬 A Closer Look at Synaptic Vesicles 🟢 Simulate neurocircuitry with the Xona Microfluidics XC-T500 3-chamber chip + Anatomic’s nociceptors & dorsal horn neurons! 🟢 Synaptophysin = synaptic vesicles 🔴 TUJ1 = neurons Recreating human anatomy, one cell at a time. #PainResearch

#CompleteTheCircuit with Dorsal Horn Neurons Dorsal horn neurons link DRG cells to the CNS, key for processing touch, pain, and temperature. Disruptions can lead to chronic pain. Discover our iPSC-based models driving pain research! #stemcells #neuroscience

How do Schwann cells shape sensory neuron function and their expression? 💡 Our fully hiPSC-based co-culture model provides the platform to explore these critical dynamics. Over time, these co-cultures show increased alignment and axonal density. #stemcells #neuroscience #pain

Did you know Schwann cells are the most abundant glial cells in the peripheral nervous system? 💡 In these images, hiPSC-derived Schwann cell precursors (S100b, SOX10) align increasingly with hiPSC-derived motor neurons (TUJ1) over time in culture. #ALS #CompleteTheCircuit #NotYourAverageNeuron

Relieving your drug screening pain points ⚡🩹 The Kolber Lab’s new pre-print highlights their development of a high-content screening platform using the Axion BioSystems Maestro Pro for analgesic drug discovery. #science #neuroscience #pain Read the article here: www.biorxiv.org/content/10.1...

💎Check-out the purity!💎Images of RealDRG hiPSC-derived sensory neuron cultures, ready for patch clamping. These cultures were generated without the need for genetic engineering or Mitomycin C. #Science #Neuroscience #Stemcells #Pain #DrugDiscovery

Anatomical relevance = physiological relevance In a local collab with Dr. Sunny Chan at UMN, we generated a same-donor tri-culture NMJ: hiPSC-derived Schwann cell precursors, motor neurons, & skeletal muscle. #CompletingTheCircuit #NotYourAverageNeuron #stemcells #neuroscience #ALS