@bvmurciasalud.bsky.social
📤 35
📥 11
📝 943
#Preevid
#Tratamiento
de elección para la disfunción eréctil en pacientes con antecedentes de
#infarto
de miocardio ✔️Los inhibidores de la fosfodiesterasa-5 (iPDE-5)❗Está contraindicada en paciente que toman nitratos
#disfunciónEréctil
👉En
https://www.murciasalud.es/preevid/26807
1 day ago
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#PubSaludMurcia
Development and Initial Psychometric Testing of a Patient-Reported Clinical Tool for Endometriosis: The Mobility Measure for Endometriosis (MobEndo) @Area2Cartagena
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Development and Initial Psychometric Testing of a Patient-Reported Clinical Tool for Endometriosis: The Mobility Measure for Endometriosis (MobEndo)
Background: Women with endometriosis frequently experience mobility limitations that affect daily functioning. A specific tool to assess these restrictions would help clinicians to better understand patients’ functional challenges, facilitating more effective communication and shared decision making. Addressing this gap is essential for strengthening patient–professional dialogue and improving individualized care. Objective: To develop the new instrument MobEndo and to perform initial psychometric testing of the tool. Methods: The initial domains and items were generated through semi-structured interviews with patients and based on experts’ advice. Guided by the International Classification of Functioning, Disability, and Health (ICF) framework, exploratory factor analysis was conducted on data from patients diagnosed with endometriosis. Internal consistency was assessed using Cronbach’s alpha, considering values ≥ 0.70 as acceptable. Test–retest reliability was examined using intraclass correlation coefficients (ICCs), and ICC values were judged as excellent if >0.75. Construct validity was evaluated through concurrent, discriminant, and known-groups validity. For the known-groups validity hypothesis, participants were categorized by baseline pain levels. Results: The final questionnaire included 18 items, developed from responses from 301 women (mean age 38.96 ± 6.85). Factor analysis revealed two components—transitioning between body positions and performing movements requiring stabilization and executing load-bearing tasks involving the upper limbs—with the model explaining 71.78% of the total variance. Reliability was excellent, with a Cronbach’s alpha of 0.977. The ICC for the total score was 0.976 (95% CI 0.949–0.988), with similarly high values for each component. Concurrent validity correlations were significant, while discriminant validity showed no relevant associations. Known-groups analyses showed clear differences across pain-level groups. Conclusions: The questionnaire is a valid and reliable tool for capturing women’s perceived mobility limitations in endometriosis.
https://doi.org/10.3390/jcm15072765
2 days ago
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#PubSaludMurcia
Retinal Microvascular Features Assessed by Optical Coherence Tomography Angiography in Attention Deficit Hyperactivity Disorder @Area6VegaMedia @AreaUnoArrixaca
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Retinal Microvascular Features Assessed by Optical Coherence Tomography Angiography in Attention Deficit Hyperactivity Disorder
Background: Attention deficit hyperactivity disorder (ADHD) lacks objective biomarkers that may complement clinical diagnosis. Optical coherence tomography angiography (OCTA) enables non-invasive quantitative assessment of retinal microvasculature and has emerged as a potential tool to explore neurovascular features associated with neurodevelopmental disorders. The aim of this study was to comparatively evaluate macular and peripapillary OCTA parameters in individuals with ADHD and neurotypical controls. Methods: This comparative case–control study involved 200 eyes (100 from 50 patients with ADHD and 100 from 50 neurotypical controls) belonging to the same well-characterized cohort previously evaluated using structural optical coherence tomography (OCT). Macular and peripapillary OCTA scans were obtained, and quantitative parameters related to vessel density, perfusion density, and peripapillary flow metrics of the superficial retinal capillary plexus were analyzed separately for right and left eyes. Group comparisons were performed using independent-samples t-tests and analysis of covariance adjusted for age, sex, and axial length, with correction for multiple comparisons. Results: After adjustment for age, sex, and axial length, no OCTA parameter showed statistically significant between-group differences after correction for multiple comparisons. Across parameters, mean differences were small and did not provide statistical evidence of an effect under the prespecified analytical framework. Conclusions: Superficial OCTA-derived microvascular parameters did not demonstrate robust between-group differences in ADHD in this cohort. These results suggest that when restricted to the superficial capillary plexus, OCTA metrics are unlikely to serve as standalone biomarkers for ADHD.
https://doi.org/10.3390/jcm15072669
3 days ago
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#PubSaludMurcia
Operating Table Height Optimization Reduces Surgeon Postural Load During Total Knee Arthroplasty: An Ergonomic Simulation Study @Area3Lorca @Area7ReinaSofia
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Operating Table Height Optimization Reduces Surgeon Postural Load During Total Knee Arthroplasty: An Ergonomic Simulation Study
Background: Work-related musculoskeletal disorders (WMSDs) are prevalent among orthopaedic surgeons as a result of prolonged exposure to non-neutral postures and forceful manual tasks during surgery. Although working height is a key determinant of trunk and upper-limb posture, the systematic evaluation of ergonomic working-height recommendations in orthopaedic surgery remains limited. Methods: A simulated left total knee arthroplasty (TKA) was divided into twelve critical surgical steps and analysed across four commonly used surgeon positions (A–D). Two conditions were compared: uncorrected working height (N) and working height corrected according to Canadian Centre for Occupational Health and Safety (CCOHS) recommendations (C). Joint angles were measured from standardized photographs using Kinovea software, and postural load was quantified with the Rapid Entire Body Assessment (REBA) method. Two trained evaluators conducted three independent assessments, yielding 288 REBA scores. Results: Mean REBA scores decreased across all surgeon positions following ergonomic correction, with statistically significant reductions observed in positions A, B, and D. When pooled across all position–step combinations (n = 48), the mean reduction was 0.92 REBA points (95% CI 0.50–1.33; p < 0.001). Notably, 27 of the 48 position–step comparisons exceeded the minimal detectable change threshold. The largest reductions occurred during force-intensive surgical steps, including bone cutting, drilling, and implant impaction. Conclusions: Adjusting working height in accordance with CCOHS ergonomic recommendations reduces surgeons’ postural load during TKA. These findings support the integration of evidence-based ergonomic adjustments into routine orthopaedic surgical practice.
https://doi.org/10.3390/jcm15072782
3 days ago
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#Preevid
¿Es eficaz la
#crioterapia
para disminuir el
#dolor
tras artroplastia total de rodilla? ✔️Disminuye el dolor percibido de forma significativa durante las primeras 48-72 horas
#artroplastiaTotalRodilla
👉Consulta la evidencia en
https://www.murciasalud.es/preevid/26806
3 days ago
0
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0
#PubSaludMurcia
Comparative effectiveness of continuous positive airway pressure and glucagon-like peptide-1 receptor agonists in obstructive sleep apnea: A network meta-analysis of randomised trials @Area6VegaMedia
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https://doi.org/10.1111/dom.70572
4 days ago
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#Preevid
Actualización: ¿Hay un "tiempo de oro" para suturar heridas no causadas por mordeduras? 🧵Hasta 18 horas y las heridas en la cabeza pueden suturarse hasta 24 horas después
#suturasHeridas
#tiempoSutura
#noMordedura
👉Toda la evidencia en
https://www.murciasalud.es/preevid/26803
4 days ago
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#PubSaludMurcia
A decade of mosquito-borne arboviral infections in the Region of Murcia: Clinical and epidemiological description of dengue and chikungunya (2014-2024) @Area7ReinaSofia @AreaUnoArrixaca
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https://doi.org/10.1016/j.eimce.2026.503159
4 days ago
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#Preevid
Levotiroxina en comprimidos, pauta de administración diaria (matutina o nocturna) más recomendada 🕥No parece haber diferencias significativas 📌Lo más importante sería que se tome con el estómago vacío
#Levotiroxina
#pautaAdministración
🔗En
https://www.murciasalud.es/preevid/26802
4 days ago
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#Preevid
Uso de
#alopurinol
en población china con
#gota
❗Debería valorarse la determinación del alelo HLA-B*58:01 ✴️En los pacientes portadores sería preferible utilizar otros hipouricemiantes
#poblaciónChina
👉En:
https://www.murciasalud.es/preevid/26800
5 days ago
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#PubSaludMurcia
The impact and role of shared decision-making in surgical practice: A systematic review @AreaUnoArrixaca
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BrowZine
https://browzine.com/libraries/4071/journals/8580/articles-in-press?showArticleInContext=doi:10.1016%2Fj.cireng.2026.800328&utm_source=nomad
5 days ago
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#PubSaludMurcia
The impact and role of shared decision-making in surgical practice: A systematic review @AreaUnoArrixaca
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BrowZine
https://browzine.com/libraries/4071/journals/8580/articles-in-press?showArticleInContext=doi:10.1016%2Fj.cireng.2026.800328&utm_source=nomad
5 days ago
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#PubSaludMurcia
Identification of new molecular mechanisms of antithrombin deficiency: six new SERPINC1 variants in a Polish cohort @DonarSangreMU
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https://doi.org/10.1016/j.thromres.2026.109656
6 days ago
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#PubSaludMurcia
Nasolabial transposition flap for reconstruction of extensive defects of the nasal midline @Area7ReinaSofia
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Journal of the European Academy of Dermatology and Venereology | Wiley Online Library
Click on the article title to read more.
https://doi.org/10.1111/jdv.70456
8 days ago
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#PubSaludMurcia
Rehabilitation interventions in bronchiectasis: expanding evidence, personalization, and clinical practice @Area6VegaMedia
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Frontiers | Rehabilitation interventions in bronchiectasis: expanding evidence, personalization, and clinical practice
Bronchiectasis is a chronic and heterogeneous respiratory disease characterized by irreversible airway dilation, recurrent infection, persistent inflammation...
https://doi.org/10.3389/fresc.2026.1785522
8 days ago
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#Preevid
Antiséptico de elección para la toma de muestras de sangre capilar mediante punción del talón en
#lactantes
✔️ Indicado: - clorhexidina acuosa al 0,5% y al 2% - alcohol isopropílico al 70º ❌Evitar: uso de antisépticos yodados 👉
https://www.murciasalud.es/preevid/26798
8 days ago
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#Preevid
¿Esta indicado el uso de
#corticoides
intranasales en el tratamiento de
#vegetaciones
en
#niños?
🔶 No identificadas GPC que recomienden su uso ✔️ En revisiones sistemáticas recientes: los niños experimentan una mejora significativa 👉👉
https://www.murciasalud.es/preevid/26795
9 days ago
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#PubSaludMurcia
The effectiveness of group-based psychological interventions for emotional distress in non-clinical adult populations: a systematic review
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The effectiveness of group-based psychological interventions for emotional distress in non-clinical adult populations: a systematic review
The demand for healthcare due to emotional distress from daily challenges has grown rapidly. Many individuals do not meet criteria for a mental disorder, yet psychotropic medication is often the fi...
https://doi.org/10.1080/09638237.2026.2646319
10 days ago
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#PubSaludMurcia Lead
I R-Wave Peak Time as a Criterion for Conduction System Capture During Left Bundle Branch Area Pacing @AreaUnoArrixaca @Area2Cartagena
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https://doi.org/10.1016/j.hrthm.2026.03.1950
10 days ago
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¿Vacuna del herpes zóster y demencia? ✔️ La vacunación frente al herpes zóster podría asociarse con un menor riesgo de demencia.
#Preevid
#vacunacion
#herpeszoster
#demencia
👉👉Más información en:
https://www.murciasalud.es/preevid/26784
10 days ago
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Webinar para
#farmacéuticos,
#médicos
(AP y otras especialidades) y
#enfermeras
del SMS y Cons. de Salud sobre búsqueda de
#fármacos, #Interacciones, Incompatibilidades
IV y dosificación para
#niños
y
#neonatos.
✏️ Inscripciones en
https://forms.cloud.microsoft/e/XL9MSrt3Z5?origin=lprLink
11 days ago
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#PubSaludMurcia
Nuevos modelos de colaboración en el equipo de atención primaria: transversalidad y coordinación. Informe SESPAS 2026 @Area9VegaAlta
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https://doi.org/10.1016/j.gaceta.2026.102572
11 days ago
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#PubSaludMurcia
Impacto de la coordinación en la calidad de la atención y los resultados de salud. Informe SESPAS 2026 @Area9VegaAlta @Area2Cartagena
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https://doi.org/10.1016/j.gaceta.2026.102570
11 days ago
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#PubSaludMurcia
Expanding the genetic landscape of inherited metabolic diseases using long-read sequencing and transcriptomic profiling @Area6VegaMedia @DonarSangreMU
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Expanding the genetic landscape of inherited metabolic diseases using long-read sequencing and transcriptomic profiling - European Journal of Human Genetics
European Journal of Human Genetics - Expanding the genetic landscape of inherited metabolic diseases using long-read sequencing and transcriptomic profiling
https://doi.org/10.1038/s41431-025-01995-7
12 days ago
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#PubSaludMurcia
Advanced in silico drug design strategies for mitigating transplant rejection: a status update @AreaUnoArrixaca
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Advanced in silico drug design strategies for mitigating transplant rejection: a status update
Current immunosuppressive regimens in solid organ transplantation (SOT) have markedly improved short-term graft survival. However, the adverse effects of these drugs, together with incomplete contr...
https://doi.org/10.1080/17460441.2026.2642965
12 days ago
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#PubSaludMurcia
Immune mechanisms driving clinical heterogeneity in oral lichen planus @AreaUnoArrixaca
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Immune mechanisms driving clinical heterogeneity in oral lichen planus - Scientific Reports
Oral lichen planus (OLP) is a clinically localized mucosal disease that nonetheless exhibits systemic immune alterations contributing to its heterogeneous presentations. This study investigated systemic immunological profiles associated with reticular (ROLP) and erosive (EOLP) OLP by analyzing circulating lymphocyte subsets and PBMC-derived cytokine secretion. Peripheral blood mononuclear cells from 91 participants (30 controls, 31 ROLP, 30 EOLP) were assessed by 24-colour spectral flow cytometry, and cytokine production was measured following CD3/CD28 stimulation. ROLP patients showed significantly elevated IL-2, IL-4, IL-17 A, and TNF-α secretion, whereas both OLP subgroups exhibited increased TGF-β1 compared with controls. Flow cytometry revealed higher frequencies of CD4⁺ Th1 cells in ROLP and increased naïve B-cell proportions in both ROLP and EOLP. Both clinical forms displayed enhanced TIGIT expression across CD4⁺, CD8⁺, and NK cells. These findings indicate distinct systemic immune signatures: a Th1/Th17-associated cytokine-driven inflammatory profile in ROLP and an inhibitory immune profile characterized by persistent TGF-β1 elevation in EOLP. Together, these data support the contribution of systemic immune dysregulation to OLP heterogeneity and highlight immunoregulatory pathways that warrant further investigation.
https://doi.org/10.1038/s41598-026-46106-8
13 days ago
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#PubSaludMurcia
Is spinal angiography useful in the differential diagnosis of myelopathies of unknown origin? Analysis of a series of 93 patients @AreaUnoArrixaca
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https://doi.org/10.1016/j.nrleng.2026.501942
15 days ago
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#PubSaludMurcia
Clinical and economic impact of the Multimorbid Patient Unit @Area2Cartagena
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https://doi.org/10.1016/j.rceng.2026.502521
16 days ago
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#PubSaludMurcia
Are we managing desmoid tumors correctly in Spain? Results of the first national survey @AreaUnoArrixaca
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https://doi.org/10.1016/j.cireng.2026.800333
16 days ago
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#PubSaludMurcia
An innovative modelling proposal for the blood supply chain @DonarSangreMU
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An innovative modelling proposal for the blood supply chain
Whole-blood donation and apheresis are the only ways to obtain blood components for human use. Tools are being developed to improve the efficiency of blood donation systems by reducing waste, increas...
https://doi.org/10.1111/vox.70234
17 days ago
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#Preevid
¿Cuántos
#hemocultivos
hay que hacer en
#pediatría?
🩸Las principales sociedades científicas consideran la toma de una sola muestra de hemocultivo pediátrico 👉Consulta la evidencia en
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https://www.murciasalud.es/preevid/26783
17 days ago
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#Preevid
Programas en las Unidades de Cuidados Intensivos Neonatales para favorecer el
#neurodesarrollo.
✔️Podrían favorecen el neurodesarrollo y otros resultados clínicos relevantes
#unidadesCuidadosIntensivosNeonatales
👉Toda la evidencia en
https://www.murciasalud.es/preevid/26793
17 days ago
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#PubSaludMurcia
Neutrophil CD14: expanding the deep vein thrombosis framework @DonarSangreMU @Area6VegaMedia
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https://doi.org/10.1182/bloodadvances.2025019211
18 days ago
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#PubSaludMurcia
Congenital ocular toxoplasmosis: Retrospective diagnosis by PCR in heel prick blood in a pediatric case @AreaUnoArrixaca
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https://doi.org/10.1016/j.eimce.2026.503139
18 days ago
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#Preevid
¿Ecografía pulmonar en niños con crisis de asma? 📌Las principales sociedades científicas no consideran la realización de una ecografía pulmonar 📌Tampoco para establecer la gravedad de una exacerbación
#asma
#ecografíaPulmonar
#niños
👉En:
https://www.murciasalud.es/preevid/26792
18 days ago
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#Preevid
Aislamiento inverso en el paciente hospitalizado con neutropenia no inducida por quimioterapia ⁉️No está claro el beneficio del aislamiento inverso en los pacientes con
#inmunodepresión
#aislamientoInverso
#neutropenia
👉Más información en:
https://www.murciasalud.es/preevid/26788
18 days ago
0
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#PubSaludMurcia
STRATIfy-PK SCORE: A predictive tool for identifying pharmacokinetic failure risk in anti-TNF-treated patient @Area7ReinaSofia
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BPS Publications
Objective The purpose of this study is to identify risk factors associated with pharmacokinetic failure, defined as immunogenicity or subtherapeutic drug concentrations, in patients treated with inf...
https://doi.org/10.1002/bcp.70346
19 days ago
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#PubSaludMurcia
Infliximab-Induced Pneumonitis in a Patient With Sarcoidosis: A Case Report @Area2Cartagena
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https://doi.org/10.1016/j.opresp.2026.100608
19 days ago
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#PubSaludMurcia
Carboplatin dosing in obese patients @AreaUnoArrixaca
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Carboplatin dosing in obese patients - Cristina Ramírez-Roig, Alberto Espuny-Miró, Raquel Olmos-Jiménez, María Sacramento Díaz-Carrasco, 2026
Objectives: The study aimed to: 1) Describe the carboplatin dosing criteria in obese patients in routine clinical practicein a general university hospital. 2) E...
https://doi.org/10.1177/10781552241292503
20 days ago
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#PubSaludMurcia
Rectosigmoidectomy versus pelvic peritonectomy in the management of seromuscular involvement of superficial rectal wall tumors in advanced-stage ovarian cancer at complete interval cytoreductive surgery @AreaUnoArrixaca
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https://doi.org/10.1016/j.ygyno.2026.02.014
20 days ago
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#PubSaludMurcia
Efectividad de la glutamina en nutrición parenteral en pacientes sometidos a trasplante de progenitores hematopoyéticos @Area6VegaMedia
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Nutrición Hospitalaria - Arán Ediciones, S.L.
Revista oficial de la Sociedad Española de Nutrición Parenteral y de la Sociedad Española de Nutrición. Está dedicada al estudio y divulgación de temas relacionados con la nutrición.
https://doi.org/10.20960/nh.06172
20 days ago
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#PubSaludMurcia
Intra-graft expression of miR-4284, miR-4286 and miR-7977 is associated with tolerance status and tacrolimus exposure in liver transplant patients @AreaUnoArrixaca
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REED - Revista Española de Enfermedades Digestivas
https://doi.org/10.17235/reed.2026.11801/2025
21 days ago
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#PubSaludMurcia
Older adults and major cardiovascular events requiring emergency department consultation during the 1st wave of the COVID-19 pandemic: results from the EDEN-4 Study @Area7ReinaSofia
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Personas mayores y eventos cardiovasculares graves que precisaron consultar en el servicio de urgencias durante la primera ola de la pandemia de COVID-19: resultados del estudio EDEN-4 – Revista Emergencias
LnRiLWZpZWxkcy1hbmQtdGV4dFtkYXRhLXRvb2xzZXQtYmxvY2tzLWZpZWxkcy1hbmQtdGV4dD0iMzU1MDRkNGI5MGU0YTQ1ODQ4MmI0MGNlMzNmMTlmNTkiXSB7IGZvbnQtc2l6ZTogMTJweDtwYWRkaW5nOiAxMnB4O2JvcmRlcjogMnB4IHNvbGlkIHJnYmEoIDAsIDExMywgMTkyLCAxICk7Ym9yZGVyLXJhZGl1czogNXB4OyB9IC50Yi1maWVsZHMtYW5kLXRleHRbZGF0YS10b29sc2V0LWJsb2Nr...
https://doi.org/10.55633/s3me/027.2026
22 days ago
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#PubSaludMurcia
Diagnosis and treatment of solitary fibrous tumors of the thyroid gland: the importance of an appropriate diagnostic approach @AreaUnoArrixaca
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https://doi.org/10.1016/j.endien.2026.501744
22 days ago
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Ayer nuestra compañera Patricia representó a la Biblioteca Virtual en tres talleres sobre
#preevid
durante las "V jornadas de tutelaje clínico: tutor@s, sembrando el futuro de la
#enfermería"
organizadas por @umuenfermeria
22 days ago
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#PubSaludMurcia
Recurrence factors in familial papillary thyroid carcinoma @AreaUnoArrixaca @Area2Cartagena
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https://doi.org/10.23736/s2724-6507.25.04264-2
23 days ago
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#Preevid
Compatibilidad de
#sertralina
y
#lorazepam
con la
#lactancia
✔️Son compatibles con la lactancia materna en caso de ser necesarios, utilizando la menor dosis eficaz y monitorizando sus posibles efectos adversos en el niño lactante 👉En
https://www.murciasalud.es/preevid/26787
23 days ago
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#Preevid
Suplementación de hierro como
#profilaxis
de anemia ferropénica en recién nacidos
#prematuros
alimentados con
#lactancia
materna 📌Se deberían administrar al menos 2 mg/kg/día
#anemiaFerropénica
#suplementoHierro
👉Más información en
https://www.murciasalud.es/preevid/26785
23 days ago
0
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#PubSaludMurcia
Genetic testing for hereditary breast and ovarian cancer in the Murcian population using a comprehensive NGS panel @AreaUnoArrixaca @Area2Cartagena @Area6VegaMedia
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Genetic testing for hereditary breast and ovarian cancer in the Murcian population using a comprehensive NGS panel - Familial Cancer
Traditionally, hereditary breast and ovarian cancer syndrome (HBOC) has been associated with germline pathogenic or likely pathogenic variants (PV/LPV) in BRCA1 and BRCA2. However, growing evidence indicates that this condition is genetically heterogeneous, and that PV/LPV in additional cancer predisposition genes also contribute significantly to disease susceptibility. In this study, 414 HBOC index cases (ICs) from the Region of Murcia, who fulfilled the 2019 Spanish Society of Medical Oncology (SEOM) criteria, were analyzed using next-generation sequencing (NGS). A 50-gene panel was applied, containing a total of 20 clinically actionable genes recommended by the National Comprehensive Cancer Network (NCCN) for HBOC. The study achieved a diagnostic yield of 15% based solely on the 20 clinically actionable genes included in the panel, with the highest detection rate observed among patients with co-occurring breast and high-grade serous epithelial ovarian cancer. Notably, applying only criteria involving a personal history of breast cancer from the 2019 SEOM guidelines limited the identification of HBOC patients carrying PV/LPV. It was also observed that BRCA genes contributed more to HBOC than non-BRCA genes (60% and 40%, respectively). Finally, re-evaluation of variants of uncertain significance (VUS) led to a substantial reduction in their number, with 25.38% of the initially identified VUS reclassified as benign or likely benign and 6 of the 97 remaining variants (6.2%) prioritized after applying a prioritization algorithm. This study confirms the importance of limiting HBOC genetic testing to clinically actionable genes in routine clinical practice. The re-evaluation and the prioritization of VUS are also essential, since they allow clinical laboratories to manage their resources more efficiently.
https://doi.org/10.1007/s10689-026-00544-5
24 days ago
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#PubSaludMurcia
Leaving nothing behind in non-complex de novo lesions: Is the time right? @AreaUnoArrixaca
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https://doi.org/10.1016/j.ijcard.2026.134451
24 days ago
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