Same #enhancer, different #names = confusion in the field 🧬 New paper introduces a standardized enhancer nomenclature for #SOX2 to improve clarity and #reproducibility in gene regulation research 🔬 https://ow.ly/futM50Z5NSs

A #paradox in #cancer #biology: 🧫 ERα is present in #ovarian and #uterine cancers—but anti-#estrogen therapies don’t always work? 🔬 This review explores why the #molecular context matters and how this shapes cancer treatment 🩺 https://ow.ly/FCic50Z5NPR

How do #cells “remember” who they are after division? 🧫 🧬 New research explores #mitotic bookmarking, a mechanism that preserves #gene expression programs through mitosis, helping maintain cell identity and function! https://ow.ly/wh9N50Z5NLN

#AI is now part of #academic life—but are we using it #responsibly? 🧬 AI can boost writing and #coding, but also raises questions about accuracy, originality, and #scientific integrity 💻 How can we harness AI without compromising #research standards https://ow.ly/u3G850YRxxJ

#Medicinal #plant with anti-obesity molecules—but the #biosynthesis pathway was unknown 🌱 Researchers identify and validate key #enzymes in polysaccharide #production, revealing functional roles for PMI, GPI, and PMM genes in the pathway 💊 https://ow.ly/83Xs50YRxvK

Renewed through 2028: ETH Zurich corresponding authors can publish open access at no cost in our journal as well as gain full read access! For more information ▶️ https://ow.ly/lems50YtISw #AcademicPublishing #AcademicSky

From #crossbreeding to #CRISPR: crop improvement has never moved faster 🧬 Review examines how #genome editing is overcoming limits of conventional breeding and #transgenics, offering precise and potentially regulation-friendly path for crop innovation 🌱 https://ow.ly/WMrN50YRxyp

Why do Western #Canadian #soybeans have lower #protein content than Eastern ones? 🌱 Not just #genetics—#environment shapes #gene co-expression networks linked to #epigenetic regulation, #photosynthesis, and #carbon metabolism, influencing protein content https://ow.ly/WOgJ50YRxrk

#Histone extraction: widely used, often unnecessarily #complex 🧬 A new straightforward HCl-based #protocol that avoids the complications of common sulfuric #acid methods while yielding high-quality histones for downstream #proteomics and #electrophoresis https://ow.ly/V8sX50YRxsT

#Inflammation doesn’t just damage #bone—it blocks #regeneration 🦴 Research show miR-20b-5p is reduced under inflammatory #stress in BMSCs, and restoring it relieves ER stressm restores osteogenic differentiation—suggesting a new lever for bone #repair https://ow.ly/Q2qo50YRxpq

Same #toxic exposure, vry different outcomes 🪰 #Nickel toxicity in #Drosophila depends strongly on #sex and #genetic background—and even mirrors copper response patterns 🧬 Surprisingly, survival tracks #starvation resistance, not metal body burden https://ow.ly/cWSl50YRxnT

Fast, #accurate, and lightweight #COVID-19 detection from chest X-rays—without heavy #DeepLearning models 🫁 ChestCovidNet, an 11-layer #network that generalizes across datasets and achieves 98.12% accuracy for multi-class #lung #disease classification https://ow.ly/e3iK50YRxnC

Did you know ETH Zurich corresponding authors can publish open access at no cost in our journal as well as gain full read access? Learn more ▶️ https://ow.ly/Nln750YtCwt #AcademicPublishing

How do #cells flip #lipids across #membranes with a single #protein? 🧫 Mapping a flippase family revealed conserved lipid pathways, a lipid/cholesterol-interacting aromatic cluster, and a #disease-linked hotspot that may hint at a new transport #mechanism https://ow.ly/RpMM50YRxn8

Canadian Science Publishing is #hiring an Institutional Account Manager with experience in sales to support institutional partnerships across key markets. Apply now: 🇨🇦 Canada: https://ow.ly/tmeZ50YRgfs 🇬🇧 UK: https://ow.ly/Zuyi50YRgbC 🇩🇪 Germany: https://ow.ly/MQn750YRgbE#hiring #AcademicPublishing

🧪💊 New #study reports synthesis of novel 3,4-dihydropyrimidin-2(1H)-one #derivatives and evaluates their #anticancer potential across cell and in vivo models 🧫 Promising selective activity with minimal genotoxicity #CancerResearch #MedicinalChemistry https://ow.ly/PJOX50YRxiZ

Looking to build your research profile? Peer review can help you stay up to date, strengthen your critical skills, and establish your expertise within your field. Learn more 👥▶️ https://ow.ly/oxPS50YNBf0 #PeerReview #AcademicPublishing

🧬 Research in esophageal #cancer suggests TRAF7 may act as a tumor suppressor: 📉 is reduced in cancer cells 🛑 slows cell growth & migration ⚰️ promotes cancer #cell death Mechanism? Tags SOX12 for #degradation, shutting down a tumor-promoting signal https://ow.ly/rw1m50YHJCK

🌱 #Plant breeding in #Canada has evolved from slow cross-breeding to precise #genome editing: 🧬 mutation breeding ✂️ CRISPR & #gene editing to develop #crops that are more: 📈 #productive 🛡️ #disease- & stress-resistant 🌍 resilient for #food security

🌿 Compound from #goji berries may help protect #nerve cells from X-ray damage In rat studies, it: 🧬 boosts cellular cleanup (autophagy) 🛡️ reduces oxidative stress 📈 improves neuron survival 👉 A potential radioprotective effect via enhanced cell repair https://ow.ly/eKA350YHJBR

🧪 When measuring #enzyme inhibitors apparent potency (IC50) can change with substrate #concentration 👉 There's often an “optimal” substrate level where inhibition is most detectable ⚠️ Bottom line: #experimental set up can change how strong a #drug looks https://ow.ly/1xM250YHJBJ

🌾 Research shows boosting #soil #microbes can't always fix salty soils In barley: 🧫 microbial inoculants can have neutral/negative effects 🧬 plant genotype & microbial community mattered a lot 👉 microbiome-based solutions must be tailored! https://ow.ly/miyy50YHJFc

🔥 #Lactate used to be thought of as a metabolic “waste product” But new research shows it can: 📉 reduces #heat-driven metabolic activity ⚡ boosts #mitochondrial function 🛡️ lowers heat-induced #cell death 👉 A role in cellular #protection https://ow.ly/LiOy50YHJB8

BCB proudly recognizes Robert Kiss from McGill University as a 2025 Outstanding Reviewer for quality, timeliness, and volume of reviews. Congrats, Robert! Learn more about our Outstanding Reviewers ⭐▶️ https://ow.ly/aw7u50YLiV7 #OutstandingReviewer

🌿 #Enzymes that build #health-related molecules found in balloon #flower ⚙️ convert basic #sugars into building blocks 🔬 work as predicted when tested in #bacteria 👉 Helping us understand how therapeutic compounds are made https://ow.ly/qFMF50YHJH1

🦴 Healing #bone isn’t just about #stem cells—it’s about what’s blocking them! Under #inflammation, bone-forming cells slow down New research shows miR-20b-5p can: ⬇️ Reduce cellular stress ⬆️ Restore bone-building activity https://ow.ly/3W4R50YHJws#bone

🐝 Protecting #bees means thinking bigger New #research highlights that bee health is shaped by: 🧬 3genetics + 🦠 #microbiomes + 🤝 social behavior + 🌍 #environment A more holistic view could be key to supporting pollinators under environmental #stress https://ow.ly/WUUi50YHJvU#bees

🧬 Pseudogene-derived variant (UbKEKS) looks like #ubiquitin—but behaves differently 🔄 binds different set of targets 🧠 shifts protein interactions due to structural changes 🚫 can’t signal proteasomal degradation 👉 Tiny sequence change = major rewiring https://ow.ly/6UPR50YHJFN

SOX2 enhancers are like switches in the #brain 🧬—but each study calls them something different! New #review maps them all out & proposes a universal naming system. #Science just got a little less confusing #Neurobiology #Genomics https://ow.ly/Oms450YqsHv

NEW! Our Read and Publish agreement with #UIO has been extended through 2028, giving affiliated authors, including those at Oslo University Hospital, read access and publishing open access options at no cost. Learn more ▶️ https://ow.ly/hrQ050YtwBo #uio Universitetet i Oslo #UIO#uio#AcademicPublishing

🧬 New work revisits an old favorite: hydrochloric acid-based #histone extraction! Simple, reliable, and compatible with SDS, 2D gels, and mass spec—making histone prep easier for downstream #analyses. #Epigenetics #HistoneResearch #MolecularBiology https://ow.ly/vAp550Yh28O

From low-coverage reads to near-complete #genomes! 🔬 Researchers show ONT reads corrected with NGS rival more expensive hybrid sequencing for #genome #assembly 🧬#GenomeResearch #ONT #NGS #GenomicsInnovation https://ow.ly/4Xt250Yh1RZ

Canadian Science Publishing is #hiring a Peer Review Coordinator to manage peer review, support authors, reviewers, and editors, ensuring quality and timeliness. Learn more and apply: https://ow.ly/RpUF50YqbyY#hiring #PeerReview #SciencePublishing #AcademicJobs

Canadian Science Publishing is #hiring a Sales Operations & Customer Support Specialist to support subscribers and authors with journals, products, and services. Learn more and apply before Mar. 26: https://ow.ly/gqiu50YpU6i#hiring #SalesOperations #CustomerSupport #JobOpening

#NewAgreement! ETH Zurich corresponding authors can continue to read and publish open access at no cost under the renewed agreement with Canadian Science Publishing, now extended through 2028. Learn more ▶️ https://ow.ly/87kL50YtASO#NewAgreement #AcademicPublishing

🍔➡️🧬 High-fat, high-sugar diets can wreak havoc on the #liver—but NEDD4L overexpression flips the switch, reducing #ferroptosis and preventing MAFLD-related liver #damage. Targeting this pathway could inspire new therapies! #MetabolicHealth https://ow.ly/Q6VS50Yh223

#Pseudogenes aren’t always silent 🧬 RPS27AP5, once considered non-functional, produces a #ubiquitin variant (UbP5) and #ribosomal #protein variant (S27aP5) that alters #mRNA association, adding evidence for ribosome diversity 👏 https://ow.ly/hsNn50Yh11e

🧠 SOX2 is a key #transcription factor for brain development & neural #stem cells—but its enhancers have been all over the map! New review untangles years of data and offers a unified roadmap for understanding SOX2 regulation across species #Neuroscience https://ow.ly/shyk50YqsEP

💊 Combining old and new: Actinomycin D + resveratrol shows enhanced #cancer cell killing in vitro via p53 activation—but in vivo, the combo doesn’t outperform the single agents. #CancerResearch #p53 #DrugSynergy https://ow.ly/4zxx50Yh2co

ERα drives most #breastcancers — but context matters 🧫 Cofactor partnerships and genomic binding differences may explain why ovarian & uterine #cancers respond differently to therapy 👩🏾‍🔬 #InternationalWomensDay https://ow.ly/sF5M50Yh1jm

Canadian Science Publishing seeks a Digital Publishing Specialist to manage metadata, support our journal platform, and improve workflows. Apply before Mar. 26 ▶️ https://ow.ly/lkKa50Yq9ux #DigitalPublishing #PublishingJobs #MetadataManagement

A #ubiquitin variant hiding in a #pseudogene? UbKEKS (from UBBP4) looks like canonical ubiquitin — but NMR reveals structural & dynamic shifts that prevent K48-linked proteasomal degradation and reshape its substrate profile 🧫 https://ow.ly/ugo950Yh0MI

Proper #brain development depends on SRCAP-driven H2A.Z deposition 🧠 Disrupting SRCAP alters #chromatin dynamics and neurodevelopmental #gene expression — advancing our understanding of developmental #disorders 🧬 #DevelopmentalDiseasesDay https://ow.ly/oo4s50Yh0Gw#brain

Rare #disease research reveals fundamental #biology 🧬 Disruption of KAT3A (CREBBP) & KAT3B (EP300) underlies Rubinstein-Taybi syndrome and informs mechanisms in #Alzheimer's disease and #Huntington's disease 🧠 #RareDiseaseDay https://ow.ly/B6kU50Yh0hI

Cervical cancer cells can become resistant to cisplatin (cDDP), a key chemotherapy drug 😟. New research shows that the tumor suppressor TRIM3 helps fight this resistance by targeting a stress-related protein, GRP78. #CancerResearch #CervicalCancer https://ow.ly/q0y350XW85B

#Diarrhea from E. coli is a major health problem in humans and animals 🦠💊 New research shows that combining bovine lactoferrin (bLf) with an antimicrobial peptide (N6) can help protect the gut and reduce inflammation #GutHealth #InfectiousDisease https://ow.ly/nIZ950XW7ZH

Why do #anti-estrogen therapies work so well in #breast #cancer but not in ovarian or uterine cancers, even when they all express ERα? 🤔 New research suggests it may depend on which cofactors ERα teams up with! #CancerResearch #BreastCancer https://ow.ly/bY1950XW7Ll

#Hiring! We are looking for an Interim Editorial Director to oversee our biological and environmental science journals. If you have a background in academic publishing and a drive to support research, this could be the perfect opportunity to make an impact. Apply now ▶️ https://ow.ly/tCa550Y9sUN#Hiring

Our most read article of 2025 explores opportunities, challenges, and ethics of AI in academia. Read it now ▶️ https://ow.ly/HYmb50XVzfj 👥: Joshua Molligan, Edel Pérez-López 🇨🇦 #BestofCSP Université Laval

🔖 During #mitosis, most #gene expression shuts down—but mitotic bookmarking keeps key regulatory proteins & lncRNAs on chromatin, guiding the next generation of cells. Aberrant bookmarking can disrupt #tumor suppressors & proto-oncogenes 🧬 #Epigenetics #CancerResearch