The October edition of Insights is out! We have a fantastic issue for you, with a report from the Cambridge University Bob Edwards event, the recording of our recent Journal Masterclass webinar, three Talking Points, article highlights, and more! sh1.sendinblue.com/ais0e855z9pf... #RBMOinsights

Two media appearances from RBMO Editor Richard Anderson this week On the BBC news, and quoted in this @theguardian.com article, commenting on the recent breakthrough in transforming skin cells into human eggs (reported in Nature Communications) www.theguardian.com/science/2025...

With a change from multi- to single step protocols, shortening vitrification as well as warming time of blastocysts, laboratory techniques were made simpler while maintaining high blastocysts survival rates and high pregnancy outcomes. doi.org/10.1016/j.rb...

A new Review article from our September issue presents that Leader Development Model - an evidenced-based training framework of five distinct elements: individual readiness, developmental experiences, new knowledge, reflection, and time. doi.org/10.1016/j.rb... 1/3

This new systematic review investigates whether gonadotrophin-releasing hormone agonist pretreatment has a positive effect on pregnancy outcomes in women with adenomyosis who were undergoing a frozen embryo transfer cycle. doi.org/10.1016/j.rb... #ClinicalAssistedReproductiveTechnology

Issue 51.4 of RBMO is out now, with 16 Research Articles, 3 Commentaries and a Review, across seven of our specialist sections! www.rbmojournal.com/issue/S14726...

As we celebrate the centenary of his birth, this Commentary article from Kamal Ahuja describes Bob Edwards as a polymath, and reflects on the profound breadth of creative influences and relationships which characterised his lifetime of achievements. doi.org/10.1016/j.rb...

Today marks the centenary of the birth of Sir Robert Edwards. In this special article in our newsletter we reflect on the legacy of the man - the polymath - responsible for the world’s first IVF baby in 1978, and our journal, Reproductive Biomedicine Online. bit.ly/RGEcentenary

We are at the Physiology Lecture Theatre, at University of Cambridge for an afternoon of lectures honouring the life, work and legacy of Sir Robert Edwards, whose work revolutionised fertility treatment through the invention of in vitro fertilisation. #RobertEdwardsCentenary #IVF

A new Commentary article from Mitchel Schiewe , marks a waypoint along our progress from “fast to fastest” approaches in the vitrification and post-warming rehydration of human blastocyst doi.org/10.1016/j.rb... #RBMOCommentary #ClinicalEmbryology

This new research article from Andrew Drakeley and colleagues presents an approach for predicting male-factor miscarriage risk by utilising the Extend® neutral comet assay. doi.org/10.1016/j.rb...

We are excited to announce the call for papers for a new special issue of RBMO: The Ovary – The Key to Female Fertility and Women’s Health. Download the pdf for details: bit.ly/rbmo-ovary-cfp #RBMOspecialIssue #TheOvary #FemaleFertility #WomensHealth

The results of this meta-analysis suggest cystectomy and ablation have similar pregnancy and recurrence rates, making them suitable for treating endometriomas in infertile women; with sclerotherapy and no treatment also providing acceptable pregnancy rates. doi.org/10.1016/j.rb...

This study highlights the potential for significant reductions in material and medication waste, reducing ecological footprint in MAR procedures, and the development of more sustainable medical practices. Read it for free from issue 51.5, now doi.org/10.1016/j.rb... #SustainabilityinIVF

A comprehensive analysis of the global burden of PCOS from 1990 to 2021 reveals a notable rise in prevalence, incidence and years lived with the disease, particularly among adolescents aged 15–19 years. doi.org/10.1016/j.rb... #PCOS #PolycysticOvarySyndrome #GlobalBurdenOfDiseaseStudy

This new review shows: ❄️ Cryoprotectants and additives protect spermatogonial stem cells (SSC) during cryopreservation. ❄️ Cryoprotectant cocktails increase protective effects. ❄️ SSC cryopreservation should be further explored to develop novel cryoprotectants. doi.org/10.1016/j.rb...

This systematic review evaluates the potential of differentially expressed sperm mRNAs associated with infertility to improve diagnostic accuracy and identify predictive biomarkers for successful assisted reproductive technology outcomes. Read if for free from issue 51.3 doi.org/10.1016/j.rb...

Selected as an Editor’s Choice paper from our August issue, 52.2 – Michael L. Eisenberg and colleagues show preconception alcohol use in either partner does not appear to be associated with higher miscarriage risk. doi.org/10.1016/j.rb... #RBMOeditorsChoice #Periconception #Alcohol 1/3

This study into sperm recovery in cystic fibrosis patients provides reassurance and personalized counselling for patients prior to sperm extraction, regarding chances of a positive result for good-quality epididymal sperm extraction and subsequent ICSI outcomes. doi.org/10.1016/j.rb...

Join our Chief Editor and team for a journal submission masterclass session with behind-the-scenes insights and advice into writing high impact articles, AI researcher tools, secrets of peer review and the final polish of science editing! us02web.zoom.us/webinar/regi...

This new review discusses pros and cons of both LN2 and ultra-low freezers in terms of economic and logistical impact, and proposes a new paradigm for sperm freezing; from expensive LN2 freezers to modular biorepositories in traditional high-tech freezers. doi.org/10.1016/j.rb...

Join us Tuesday, 16 September, when our RBMO LIVE webinar will provide behind-the-scenes insights from our Editorial team in a Journal Submission Masterclass on writing and peer review. Let’s meet one of our speakers, RBMO Development Editor @dnjournals.bsky.social bit.ly/RBMOlive13 1/3

🔥 New Hot Topic selection! Exercise: a simple intervention that can be suggested when men say ‘but what can I do to help?’ Of course, we need a RCT to show causality, or will we be forever plagued by mere association? doi.org/10.1016/j.rb... #RBMOHotTopic #Andrology #MaleFertility

Join us Tuesday, 16 September for a special Journal Submission Masterclass edition of RBMO LIVE. Joining our Editorial team for the webinar will be Dr Gareth Dyke – consultant to author services and publishing companies, with over 380 peer reviewed publications to his name. bit.ly/RBMOlive13 1/3

This review from issue 51.2 provides detailed information on the latest updates and evolution of cryopreservation in assisted reproductive technology, from its origins in slow freezing to the introduction of new, efficient equilibration and rehydration protocols. doi.org/10.1016/j.rb...

Join us, Tuesday 16th September from 3pm EST for a masterclass in modern, high impact research publishing, with Chief Editor Nick Macklon, guest speakers and the team behind-the-scenes of one of the top journals in the field of reproductive medicine. bit.ly/RBMOlive13

The authors of this Review say IVF/ICSI should be prioritized as the initial infertility treatment in endometriosis, reserving surgery for symptom management, patient-specific factors, or clearly defined clinical indications for optimal outcomes and patient safety. doi.org/10.1016/j.rb...

This pilot study explores the impact of sexual intercourse on serum progesterone levels during an HRT cycle utilizing vaginal progesterone suppositories. The full paper is available now as a pre-proof to RBMO subscribers from our in-press articles section now: doi.org/10.1016/j.rb...

In this new Commentary article, former RBMO Chief Editor, Bart Fauser and Arie Franx outline how current outcome measures could detrimentally affect the way ART is practiced, and propose ways to improve such outcomes. doi.org/10.1016/j.rb... #ClinicalAssistedReproductiveTechnology #ARToutcomes

The authors say that above all, vitamin D deficiency was associated with worse phenotypes, especially higher androstenedione level in PCO, and sufficient vitamin D may be helpful in improving phenotypes in infertile women with PCOS. doi.org/10.1016/j.rb...

September's edition of RBMO Insights is out now, with: 📑 A new special issue call for papers on The Ovary 🗨️Talking Points on Blastocysts, Pregnancy Loss, and Sir Robert Edwards ♂️An Andrology Section Profile with Sandro Esteves... ➕...and more! sh1.sendinblue.com/aifda855z9pf...

This large multicenter cohort study indicated that between frozen embryo transfer (FET) may reduce the risk of monozygotic twinning (MZT) at the blastocyst stage. doi.org/10.1016/j.rb... #ClinicalAssistedReproductiveTechnology #Blastocyst

This network meta-analysis evaluates the effectiveness of progestogen administration routes on clinical pregnancy (CPR) and live birth rates (LBR) in fresh IVF cycles, and shows that oral and intramuscular progestogens may be more effective in improving IVF outcomes. doi.org/10.1016/j.rb...

This new review explores all repair mechanisms present in the oocyte for correcting sperm DNA damage, their potential effects on early embryo development, along with an evaluation of their clinical implications. doi.org/10.1016/j.rb...

This new narrative review examines the physiological and pathological roles of E2 in natural and ART cycles, emphasizing its impact on endometrial function, implantation, and pregnancy outcomes. doi.org/10.1016/j.rb... #ClinicalAssistedReproductiveTechnology

This new study shows rapid-warming protocols provide similar to superior results compared to the conventional thawing approach. A universal protocol would increase the efficiency of ovarian tissue thawing/warming, potentially optimizing costs and improving outcome. doi.org/10.1016/j.rb...

This new research project is the first to examine decision-making pathways for oocyte disposition outcomes for elective egg freezers. The study highlights the importance of counseling focused on attitudes and unique influences relevant to each outcome. doi.org/10.1016/j.rb...

This study is the first to show that even normal term pregnancies after ART show significantly altered microRNA gene expression profiles in the first trimester of gestation compared to pregnancies after NC. doi.org/10.1016/j.rb...

Issue 51.3 of RBMO is out now, with 19 Research Articles and 2 Reviews across our 8 specialist sections, plus correspondence discussing the efficacy of ovarian stimulation regimen based on randomized trials. www.rbmojournal.com/issue/S1472-...

This extensive Review article evaluates the efficacy of three promising alternative technologies for assessment of ploidy status in IVF embryos (PGT-A): Artificial intelligence (AI), non-invasive (ni)PGT-A and metabolomics. doi.org/10.1016/j.rb...

Issue 39 of RBMO Insights is out today! This month we talk lab witnessing, ovarian reserve, congenital anomalies in ART, preview our 'submission masterclass' RBMO Live webinar in September, spotlight our Reproductive Endocrinology and Health section, and more! sh1.sendinblue.com/ai6xvk55z9pf...

This study has implications for PTX-treated cancer survivors; revealing details about the timing of conception and offspring safety after chemotherapy, offering a basis for for patients treated with PTX therapy. available now as a pre-proof from our in-press articles doi.org/10.1016/j.rb...

This study is the first to show that hormonal replacement therapy may lead to a significant increase in serum TSH levels in women undergoing HRT for endometrial preparation before embryo transfer. doi.org/10.1016/j.rb...

This new study from The Rotterdam Periconception Cohort project team at Erasmus MC, University Medical Center, demonstrates that a higher degree of periconceptional vulnerability, as quantified by the PVRS is inversely associated with embryonic growth parameters. doi.org/10.1016/j.rb...

This work reflects real clinical practice, and provides a proof of concept methodology that IVF centres may employ to establish their own thresholds which after validation, can be used for patient counseling and to facilitate the workload of the IVF laboratory. doi.org/10.1016/j.rb...

This study demonstrates that objectively trained AI tools such as EMBRYOLY can support embryologists in difficult scenarios, especially in cases where they might be discouraged from transferring any embryo even though these stand a chance to lead to a pregnancy. doi.org/10.1016/j.rb...

In the pathogenesis of endometriosis, LINC01638 may act as a chromatin remodeller by modulating the levels of expression of HDAC1 to induce partial EMT in endometriotic lesions. RBMO subscribers can read the full paper from issue, 51.3, now: doi.org/10.1016/j.rb...

Comparing euploidy rates between blastocysts derived from poor- and good-quality day 3 embryos, this study demonstrates that the morphology of day 3 embryos does not influence the quality of the transferrable blastocysts they develop into. doi.org/10.1016/j.rb...

Our August issue, 51.2 is published in full on our website now, featuring 24 original research and review articles, viewpoints and commentaries from our eight specialist subject sections - including 10 open access and free articles www.rbmojournal.com/issue/S1472-...

The positive effects of HNG shown in this study may ameliorate the ovarian damage induced by CTX chemotherapy, which suggests the need for further investigation of HNG as a protective agent of the ovary. doi.org/10.1016/j.rb...