#MS_Selfie Newsletter on the Lazarus effect in MS. Is it real? When someone transitions from almost being confined to a wheelchair to being able to walk and run, we call this the Lazarus effect. Does CAR T-cell therapy hold promise as a cure for MS? => buff.ly/woSREfb

#MS_Selfie Q&A 123: treating MS over the age of 70 If I were over 70 and had MS, I would advocate for a proactive approach to my MS treatment. Do you agree? =>

#MS_Selfie Breaking News: Fenebrutinib Press Release My predictions may be correct. What were yours? Is this the game-changer we were hoping for? => gavingiovannoni.substack.com/p/breaking-n...

#MS_Selfie Newsletter: Are you aware of SAW? Would you want to know if you had smouldering MS? I am acutely aware of how often you have been gaslit when it comes to smouldering MS. Please share your experiences => buff.ly/xKWBbf4

#MS_Selfie Q&A 122: Comorbid Graves disease Another option is teriflunomide, which does not cause chronic immunosuppression and may help your Graves orbitopathy. buff.ly/5Jfzz2H

#MS_Selfie Q&A 121: Is ofatumumab superior to ocrelizumab? Ocrelizumab showed a trend toward statistical significance, but didn’t make the final cut. Does this mean ofatumumab is superior to ocrelizumab? What do you think? =>

# MS_Selfie Newsletter - MS and divorce If I were to design a comprehensive MS service, I would ensure that relationship counselling was part of the core services we offer. Do you agree? => gavingiovannoni.substack.com/p/ms-and-div...

#MS_Selfie Q&A 120: emotions and MS Does multiple sclerosis affect your emotional state? Please help and share your experiences => buff.ly/fIRZUY2

Will this MSARD Editorial on "When does multiple sclerosis start?" impact the field of MS and change the way we think about the disease? => www.msard-journal.com/article/S221...

#MS_Selfie Newsletter - Nitrofurantoin warning: please read Nitrofurantoin is a commonly prescribed antibiotic for urinary tract infections (UTIs) and is also used long-term as a urinary antiseptic to prevent UTIs. => buff.ly/7gPsotL

#MS_Selfie: Which formulation of HRT would you recommend? "It is encouraging to see these large-scale reconsiderations of the beneficial effects of HRT. However, it is upsetting that a generation of women missed out on the process.” => buff.ly/XI08YEN

#MS_Selfie Q&A 118: ECTRIMS 2025 & CAR T-cells I believe this is one of the most promising therapeutic strategies being tested in MS for several reasons: its CNS and deep tissue penetration, as well as its anti-EBV properties. => buff.ly/dE1kODU

#MS_Selfie Q&A 117: ECTRIMS 2025 - EBV & MS If EBV is necessary for the development of MS, why wouldn't we consider including EBV serology as part of the MS diagnosis? => buff.ly/h5QHqgM

#MS_Selfie ECTRIMS 2025: blowing my own horn The highlight of the meeting was my presentation of the ocrelizumab results in the PPMS O’HAND study, which were positive. buff.ly/EWHOuBw

#MS_Selfie Q&A 116: Which antiviral? There is a fine line between being an innovator and a quack. The observational data strongly support moving forward with EBV antiviral strategies in MS .... buff.ly/8CaFvBv

What a journey for people with MS and their HCPs. Natalizumab has taught us a great deal about MS. We try to tell the story in this review paper => buff.ly/WWjC7Ql

#MS_Selfie - Prof G's response to the AI-generated newsletter

#MS_Selfie Q&A 115: AHSCT or not? Anxiety and uncertainty are not good bedfellows when considering treatment options for multiple sclerosis. Should this young woman have the option of AHSCT? => buff.ly/e7bwckp

#MS_Selfie: How useful is AI-generated content in the field of MS? I have been having a back-and-forth argument with colleagues about the value of AI in MS research. I therefore asked Google Gemini Pro 2.5 Deep Research the following question: ... -> buff.ly/v3ot0m6

#MS_Selfie Q&A 114: Muscle loss and sarcopenia on GLP-1 receptor agonists If you have been prescribed a GLP-1 RA, did your HCP assess your muscle function at baseline and provide you with information about how to prevent muscle loss? Are you having regular assessments? => buff.ly/qn6S9wI

#MS_Selfie Q&A 113: Should I take creatine supplements? If you have started taking creatine, have you noted any impact on your MS symptoms, level of functioning and quality of life? => buff.ly/LumDjFy

Burnout RX: HCP's silent struggle impact.economist.com/health/healt...

#MS_Selfie - Energy drinks vs. Coffee Are you self-medicating MS-related symptoms using energy drinks or coffee? => buff.ly/2CGG9Za

#MS_Selfie Q&A 112: Latent TB

#MS_Seflie Q&A 111 (a Nelson): Glucagon-like peptide-1 receptor agonists (GLP-1RAs) Should I start tirzepatide or semaglutide to treat my MS? => buff.ly/OueDpzp

DR KRISTEN KRYSKO WINS 2025 RACHEL HORNE PRIZE FOR WOMEN’S RESEARCH IN MULTIPLE SCLEROSIS

#MS_Selfie Q&A 110: Anxiety and MS If you have a significant problem with anxiety and/or depression, please discuss this with your HCP. Simply living with anxiety and depression as a ‘new normal’ is not a solution. buff.ly/3VAmZVZ

#MS_Selfie Q&A 109: Antivirals as treatment for MS I would be interested to hear how many of you have started taking antivirals as a potential treatment for your MS; if so, who prescribed the antivirals? buff.ly/N88fBfB

#MS_Selfie Newsletter - Q&A 108: Dairy Sensitivity and MS I apologise for the delay in responding to your question. It has taken me some time to review the relevant literature. I hope this newsletter helps. => buff.ly/DXuPiwj

#MS_Selfie Q&A 107: a new AI-generated classification system for MS progression. Including an AI-generated podcast to describe the research underpinning this classification system. => gavingiovannoni.substack.com/p/q-and-a-10...

#MS_Selfie - Does MS-Selfie have a future? Am I making the lives of my colleagues, including general practitioners (GPs), more difficult and creating unrealistic expectations of what can be realistically offered to people with MS? buff.ly/fCubjcb

#MS_Selfie - Recurring UTIs - some non-antibiotic solutions How many of you have been taught how to self-manage your bladder to prevent UTIs? buff.ly/5WwcoJB

#MS_Selfie - Complicated Urinary Tract Infections in people with MS. New guidelines on the classification and management of complicated UTIs. Please be aware that UTIs are one of the MS elephants in the room and need to be taken seriously. =>

#MS_Selfie Q&A 106: Do I have a functional neurological disorder or MS? Did any of you get misdiagnosed with a functional neurological disorder (FND) that was later changed to MS? You may have some advice for this patient. It seems she is in a quandary. Thank you. => buff.ly/l0x1DSV

#MS_Selfie Q&A 105: Biohacking to take hydroxychloroquine or not Would you recommend taking hydroxychloroquine off-label in a similar way to metformin? => buff.ly/9OtXAjy

In this systematic review on the prediction of long-term outcome in Multiple Sclerosis, we try to identify factors that can be included in a prognostic calculator. Please note this calculator needs to be coded and then validated #MS_Selfie => buff.ly/ZhWyK86

#MS_Selfie Newsletter - Predicting worsening MS - to know or not to know How many of you would want to know your prognosis, i.e. your chances of worsening MS? If yes, in what format would you like the information to be in? buff.ly/nkeuK66

#MS_Selfie Q&A 104: Autonomic dysfunction in MS One must not assume that all autonomic symptoms are due to multiple sclerosis ... buff.ly/ce7DK95

"One in five UK doctors are considering quitting, regulator warns" => buff.ly/wLXzZkH This is a staggering finding. The reasons are multiple and include burnout, deprofessionalisation, poor working conditions, high student loans, low pay, ....

#MS_Selfie - Planning for death MS is rarely a life-threatening disease. But as in life, MS has a terminal phase. Here are some things to consider when planning for your death. => buff.ly/bPLvmUV

#MS_SELFIE_RESEARCH - When did you develop MS? How long is the MS prodrome? I would be interested to know if any of you recall being unwell in the decade or so before you developed clinically apparent MS. => buff.ly/54doMXb

#MS_Selfie Q&A 103 - Advanced MS - what can be done? What type of MS do I have? Have I converted to having secondary progressive MS? What treatments are possible? Is there any possibility of switching to another DMT? buff.ly/AaG9nAz

#MS_Selfie Q&A 102: Should I take vitamin K? Vitamin K has many effects on the body. I would be interested to hear if any of you are taking vitamin K or specifically K2? Who recommended it, and have you noticed any effect? => buff.ly/EzwaJuu

#MS_Selfie Newsletter - Does MS cause dementia? I would be interested to know if any of you think you have severe cognitive impairment or dementia. Have you raised this with your MS team? Have they sent you for a cognitive assessment? => buff.ly/1TiMet3

#MS_Selfie Q&A 101: worsening visual blurring If someone experiences visual changes due to MS, does it always show up on optic nerve scans and eye exams? To find out => gavingiovannoni.substack.com/p/q-and-a-10...

#MS_Selfie Newsletter - Let's get political: NHS resident doctors strike I would like to hear if your MS care has been affected by the strikes and what your position is on the strike. As always, the practice of medicine is a political endeavour. => buff.ly/wK0uD4I

#MS_Selfie Q&A 100: Comparing DMTs Should I change my decision and switch to Ocrevus (ocrelizumab) instead? What do you think? => buff.ly/gUqfhid

#MS_Selfie Newsletter - Is rituximab really superior to cladribine as a treatment for MS? It is important to debunk this analysis of rituximab vs. cladribine because both agents are on the WHO’s essential medicine list (EML) as treatments for MS. => buff.ly/FFDMUbV

#MS-Selfie Newsletter - How to avoid a DMT cul-de-sac? You should try to push back from being labelled as having SPMS or PPMS to prevent limiting your treatment options. buff.ly/Ub3K0HZ

How sad? 😪 Measles Cases Hit Highest Total Since U.S. Eliminated Disease buff.ly/R9Bwg0y