Modeling human prenatal adrenocortical functional zonation dynamics from pluripotent stem cells

Featured in Penn Today: our human adrenal organoid platform. Rather than modeling hormone output alone, we reconstruct progenitor-driven zonal architecture providing a new framework to study how stem cells build and maintain endocrine function. penntoday.upenn.edu/news/stress-...

Thrilled to share our new paper in Cell Stem Cell! 🧬 We generated stem cell–derived human adrenal tissue with functional zonation, recapitulating key aspects of the adrenal cortex’s 3D architecture and steroidogenic activity. www.cell.com/cell-stem-ce... Kudos to the entire team!

Synthetic and stem cell endocrinology: Join Our Team to Recreate the Human Adrenal Gland and hypothalamic-pituitary-adrenal Axis Using the Power of Stem Cells. t.co/1z16UstQqY

Thrilled to share our latest preprint! We have successfully reconstituted a human adrenal cortex from stem cells, achieving functional zonation both in vitro and in vivo. www.biorxiv.org/content/10.1...