Harvard Medical School Division of Sleep Medicine (@harvardsleepmed.bsky.social)

Prof. of Neurology, Dr. Tom Scammell, and colleagues show that an orexin receptor 2 (#OX2R) agonist improves the maintenance of wakefulness, and highlights some of the neural pathways through which this occurs #HarvardSleepMed www.cell.com/current-biol...

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An orexin agonist promotes wakefulness and inhibits cataplexy through distinct brain regions Ishikawa et al. show that an orexin receptor 2 (OX2R) agonist improves the maintenance of wakefulness through OX2R in the tuberomammillary nucleus (TMN) and basal forebrain (BF) regions and suppresses... https://www.cell.com/current-biology/fulltext/S0960-9822(25)00356-2