Activating #EGFR variants were identified in early-onset, severe generalized #AcanthosisNigricans with pulmonary nodules; EGFR inhibitor therapy improved both skin and lung disease. ja.ma/4rKi9CP

Intralesional interleukin-2 immunotherapy produced an 81% complete response rate with only mild adverse events in patients with high-risk #SquamousCellCarcinoma not eligible for surgery. ja.ma/41fIdd4

Eosinophilic fasciitis (EF) is a rare disease in which the fascia, the tissue that covers the muscles, becomes inflamed. 📄 This Patient Page describes the symptoms, diagnosis, and treatment of eosinophilic fasciitis. ja.ma/4smysFQ

Lutikizumab at 300 mg weekly or every other week improved clinical outcomes compared with placebo in adults with moderate to severe #HidradenitisSuppurativa who experienced anti–tumor necrosis factor therapy failure. ja.ma/4sCECSN

Once-daily oral ICP-332, a tyrosine kinase 2 inhibitor, showed favorable safety and significantly improved disease severity versus placebo in adults with moderate to severe #AtopicDermatitis. ja.ma/4aKOF1C

In 2025, JAMA Dermatology evaluated >3,400 manuscript submissions and maintained an Impact Factor of 11. Read the full “JAMA Dermatology—The Year in Review, 2025,” by Editor in Chief Kanade Shinkai, MD, PhD. ja.ma/4biuUyG

📃 Case report describes a man in his 90s with granulomatous dermatitis successfully treated with topical delgocitinib. ja.ma/4blswGf

#HidradenitisSuppurativa is associated with increased risks of self-harm and suicide, highlighting the importance of clinician vigilance and multidisciplinary mental health support. ja.ma/4ukagFV

A man in his 50s presented with a 4-mo history of pruritic, verrucous lesions on the right lower leg. What is your diagnosis? Take the Clinical Challenge: ja.ma/3N640R8

A woman in her 30s presented with a chronic, painful, nonhealing ulcer on her fifth finger that developed after trauma 1 year earlier. What is your diagnosis? ja.ma/4ajeDcb

Among patients previously treated for early-stage #Melanoma, nearly half reported fear of recurrence and 20% had not performed skin self-examination in the prior year; half lacked confidence in skin self-examination. ja.ma/4kZt74N

In a clinic-based survey, patients demonstrated variable understanding of skin cancer–related terminology, with only 64.2% correctly identifying "clear margins" and 21.6% understanding "dysplastic nevus." ja.ma/4qAh1zZ

Nearly 20% of acral lentiginous melanoma cases lacked the parallel ridge pattern, highlighting the need for improved diagnostic criteria and supporting the expansion of evidence-based dermoscopic benchmarks for early detection. ja.ma/4aSoWmw

A man in his 50s developed broad-spectrum abnormal localized photosensitivity syndrome, presenting as recurrent sun-induced, site-specific erythematous plaques confirmed by targeted phototesting. ja.ma/3OJvUTj

Systematic review: Accurate classification of dermatologic conditions using International Classification of Diseases (ICD) codes is essential for research that uses large administrative datasets. ja.ma/4kXmeB3

The TIP-CA model uses five clinical factors—including TIF1-γ antibody status, interstitial lung disease, poikiloderma, DM subtype, and anemia—to stratify cancer risk in DM patients. ja.ma/4tCLCzP

This case report describes a woman in her 20s with a history of linear morphea diagnosed in childhood who presented with disease progression despite long-term treatment. ja.ma/4kBw77f

Systematic review & meta-analysis identifies diclofenac and silymarin as the most efficacious interventions for the prevention of hand-foot syndrome, with diclofenac having the best supporting evidence based on both effect size & study quality. ja.ma/3N9Qbkz

For patients with stage IA to IIC #Melanoma, time to recurrence was associated not only with ulceration and thickness but also with tumor location, mitoses, neurotropism, and lymphovascular invasion. ja.ma/4rUaLEG

The Ectropion Severity Score demonstrated excellent reliability in grading ectropion across genotypes in epidermal differentiation disorders, with highest severity observed in TGM1-nEDD and ABCA12-nEDD. ja.ma/47g7iYK

Among bionaive patients with #Psoriasis in Denmark, ustekinumab had superior drug survival compared with adalimumab and secukinumab over 5 years. ja.ma/4qAgYEj

This case report describes a woman in her 20s with hereditary leiomyomatosis and renal cell carcinoma. 📄 Read the full report: ja.ma/4aYvXm0

Among patients after allogeneic hematopoietic cell transplant, 5.5% were diagnosed with demodicosis, presenting as pruritic folliculocentric eruptions with characteristic sparing of periocular skin and scalp. ja.ma/46ciG7D

This systematic review & network meta-analysis identifies diclofenac and silymarin as the most efficacious interventions for the prevention of hand-foot syndrome, with diclofenac having the best supporting evidence based on both effect size & study quality. ja.ma/403jN68

Case report describes a patient in his 50s with immunoglobulin A vasculitis with monoclonal B-cell lymphocytosis who was successfully treated with zanubrutinib after failure of multiple treatments. ja.ma/4aEscln

For patients with stage IA to IIC #Melanoma, time to recurrence was associated not only with ulceration and thickness but also with tumor location, mitoses, neurotropism, and lymphovascular invasion. ja.ma/4lbb4sj

Patient-Reported Outcomes Measurement Information System (PROMIS) measures for pain, itch, social satisfaction, and isolation showed strong validity and tracked clinical improvements in adults with chronic skin disease. ja.ma/3ZzYNnr

An adolescent female presented with 3 days of progressive abdominal pain and reported that a rash first appeared nearly 1 year earlier on her left wrist and gradually spread over several weeks. What is your diagnosis? ja.ma/3MHsVu6

This case report describes a man in his 30s who presented for evaluation of a 3-week history of irritation, redness, and photophobia in both eyes. ja.ma/46SSpLP

In this economic evaluation, #psoriasis treatments provided substantial patient value, with biologics delivering the largest mean gains, phototherapy remaining effective but underused, and step-therapy regimens achieving comparable efficacy at lower cost. ja.ma/4l56iN1

Latine patients with #HidradenitisSuppurativa report unmet wound care and pain management needs, frequent self-directed care, and barriers created by interpreter-mediated communication, supporting the need for improved multidisciplinary approaches. ja.ma/3ZF5ZP1

Among displaced persons at Mexico-US border humanitarian relief camps, infectious and inflammatory skin diseases were frequently diagnosed, especially in children and areas with overcrowding. ja.ma/4s4GMtk

Higher #BMI and inflammatory bowel disease were causally linked to increased risk of #HidradenitisSuppurativa, while the association with smoking was inconclusive after sensitivity analyses. ja.ma/4bY8C5V

A man in his 60s undergoing #radiotherapy for prostate #cancer presented to the dermatology clinic with a 1-week history of a tender, pruritic rash to the trunk and extremities. What is your diagnosis? ja.ma/4qRy1SA

Analysis of Global Burden of Disease data from 1990 to 2021 shows a gradual rise in #psoriasis incidence for both sexes worldwide, with projections indicating continued increases by 2050. ja.ma/4kA7LKW

In this economic evaluation, #psoriasis treatments provided substantial patient value, with biologics delivering the largest mean gains, phototherapy remaining effective but underused, and step-therapy regimens achieving comparable efficacy at lower cost. ja.ma/46pM22y

Monthly vixarelimab led to rapid and sustained improvement in pruritus and lesion severity for adults with #PrurigoNodularis, with no serious drug-related adverse events reported. ja.ma/4azhD38

Progress toward the 2030 Sustainable Development Goals for skin-related neglected tropical diseases is insufficient globally, with widening regional inequalities and only a few countries on track for target achievement. ja.ma/3OoCizw

Between 2013 and 2022, the share of #Dermatology specialty drug spending by advanced practice clinicians rose from 10% to 31%, driven by a faster increase in APC numbers and prescribing intensity compared to physicians. ja.ma/4tB7mvS

Although polarized dermatoscopes yielded more reportable images and fewer quality issues, a lower-cost, ambient-light, nonpolarized dermatoscope provided comparable clinical utility at a fraction of the cost. ja.ma/46UDfFU

Encouraging use of lower-priced #sunscreens and sun protective clothing may help reduce the financial burden and support adherence to recommended skin protection behaviors. ja.ma/4qTRRfY

In a multicenter study, cross-modal imaging aligned with biopsy-confirmed histopathology and showed high physician reader agreement, supporting its FDA-cleared role in clinical assessment. ja.ma/4kGJVNR

Biologic therapy adherence, discontinuation, and selection varied across racial and ethnic groups in Medicaid patients with #Psoriasis, pointing to disparities that affect long-term management and outcomes. ja.ma/4cCiW3E

This case report describes a pruritic rash on the trunk and erythematous patches with numerous flaccid, half-half pustules that contained clear and purulent fluid. 📄 Read the full case report: ja.ma/46FAtEo

Bimekizumab provided rapid and sustained improvements in symptoms and quality of life for patients with moderate to severe #PlaquePsoriasis, with benefits maintained through 3 years. ja.ma/4rtcgJT

Dupilumab significantly reduced itch and hives severity in anti–immunoglobulin E–naive patients with chronic spontaneous urticaria uncontrolled by H1-antihistamines, with early and sustained improvements seen through week 24. ja.ma/40cqgM5

Encouraging use of lower-priced #sunscreens and sun protective clothing may help reduce the financial burden and support adherence to recommended skin protection behaviors. ja.ma/3ORUMID

Bimekizumab provided rapid and sustained improvements in symptoms and quality of life for patients with moderate to severe #PlaquePsoriasis, with benefits maintained through 3 years. ja.ma/3ZF5S63

Encouraging use of lower-priced #sunscreens and sun protective clothing may help reduce the financial burden and support adherence to recommended skin protection behaviors. ja.ma/3Mt1EeU

A man in his 30s presented with a 2-month history of hair loss on the entire scalp and the lateral portions of both eyebrows. Results of the hair-pull test were negative. What is your diagnosis? ja.ma/4661hgW