In a large cohort of adults with hypopigmented #mycosis #fungoides, most had early-stage disease and responded well to skin-directed therapy, with stage progression observed in only 6%. ja.ma/4eCAuMA

This consensus statement develops a core outcome set of essential domains to be reported in #clinical trials evaluating the efficacy of interventions for facial #aging. ja.ma/3SrC1Oc

In refractory #rosacea, paroxetine therapy was associated with systemic proteomic changes in neuro-vascular-immune pathways and identified circulating protein #biomarkers linked to #clinical improvement. ja.ma/4xOI5Aj

💬 Editorial: Efforts to unify remission criteria in #AtopicDermatitis through clinician and patient measures highlight progress for research and guidelines, yet require further evaluation for feasibility and patient relevance. ja.ma/4gCLOea

This systematic review examines potential clinical, laboratory, and treatment-related factors associated with progression from acute to chronic urticaria. ja.ma/4g4T9TM

Among more than 780 000 children in Denmark and England, #AtopicDermatitis was not linked to poorer academic performance on national exams regardless of disease phenotype or socioeconomic background. ja.ma/4oJrqdo

In high-risk cutaneous squamous cell #carcinoma, ultrasonography and CT detected baseline nodal metastases more accurately than physical examination, but both modalities performed poorly in #immunosuppressed patients. ja.ma/4y1UOA7

Commercial payer-negotiated prices for 15 common #Dermatology procedures varied widely across US hospitals; median prices were lower than list, higher than #Medicare, and lower in rural vs nonrural facilities. ja.ma/4uIYjbG

📄 This case report describes 2 household members who presented with intensely pruritic eruptions from the scalp to the extremities. ja.ma/3Shrzsy

In a large cohort of adults with hypopigmented #mycosis #fungoides, most had early-stage disease and responded well to skin-directed therapy, with stage progression observed in only 6%. ja.ma/3SQbWbz

This consensus statement develops a core outcome set of essential domains to be reported in #clinical trials evaluating the efficacy of interventions for facial #aging. ja.ma/4xCtKH5

In refractory #rosacea, paroxetine therapy was associated with systemic proteomic changes in neuro-vascular-immune pathways and identified circulating protein #biomarkers linked to #clinical improvement. ja.ma/4eSJwGw

Keratinocyte carcinoma prevention with nicotinamide was cost-effective and patient-centered, reducing treatment costs and providing measurable quality-of-life benefit. ja.ma/4w0Jfaz

No significant difference in melanoma mortality trends was observed between Germany's #SkinCancerScreening program and neighboring countries, suggesting limited population-level impact. ja.ma/3QBvakB

Keratinocyte carcinoma prevention with nicotinamide was cost-effective and patient-centered, reducing treatment costs and providing measurable quality-of-life benefit. ja.ma/4e9TYJH

No significant difference in melanoma mortality trends was observed between Germany's #SkinCancerScreening program and neighboring countries, suggesting limited population-level impact. ja.ma/43YQbIX

Keratinocyte carcinoma prevention with nicotinamide was cost-effective and patient-centered, reducing treatment costs and providing measurable quality-of-life benefit. ja.ma/4v43xjl

An adolescent boy presented with more than 10-year history of skin discoloration and difficulty protruding the tongue. What is your diagnosis? Take the JAMA Dermatology Clinical Challenge: ja.ma/4e1kOn3

No significant difference in melanoma mortality trends was observed between Germany's #SkinCancerScreening program and neighboring countries, suggesting limited population-level impact. ja.ma/3PWjUPE

Pediatric patients waited 68% longer for appointments with pediatric dermatologists than with general dermatologists, and >30% of general dermatologists did not accept new pediatric patients. ja.ma/442Y7ZJ

Among adults with refractory #HidradenitisSuppurativa, golimumab led to durable improvement in disease severity; most responders used doses of 200–300 mg every 3–4 weeks. ja.ma/4ehcBKq

#HidradenitisSuppurativa is associated with increased risks of self-harm and suicide, highlighting the importance of clinician vigilance and multidisciplinary mental health support. ja.ma/4ehM1Rt

Joachim Hübner, PhD, and Alexander Katalinic, MD, discuss recent findings comparing #melanoma mortality rates in Germany from 2009 to 2022 with those in nine neighboring countries without population-wide screening programs. 🎧 Listen to the podcast: ja.ma/3Qy67Pp

Keratinocyte carcinoma prevention with nicotinamide was cost-effective and patient-centered, reducing treatment costs and providing measurable quality-of-life benefit. ja.ma/49P7i3o

No significant difference in melanoma mortality trends was observed between Germany's #SkinCancerScreening program and neighboring countries, suggesting limited population-level impact. ja.ma/3QercOK

This case report describes a woman in her 30s with melanoma arising in association with a BAP1-inactivated melanocytic tumor. ja.ma/3QutF7J

Intralesional interleukin-2 #immunotherapy produced an 81% complete response rate with only mild adverse events in patients with high-risk squamous cell #carcinoma not eligible for #surgery. ja.ma/4olTVhk

This case report describes well-circumscribed, yellow-brown atrophic plaques on the legs that were rimmed by erythema and scale. ja.ma/4e8eklh

This case report describes a woman in her 30s with melanoma arising in association with a BAP1-inactivated melanocytic tumor. ja.ma/4ay6EHM

Intralesional interleukin-2 #immunotherapy produced an 81% complete response rate with only mild adverse events in patients with high-risk squamous cell #carcinoma not eligible for #surgery. ja.ma/3QqKRuR

Biologic therapies targeting IL17 and IL23 achieved the highest short-term Psoriasis Area and Severity Index 90 responses for chronic plaque #Psoriasis, with low rates of serious adverse events similar to placebo. ja.ma/43OSePP

Monthly rifampin, moxifloxacin, and minocycline therapy for Hansen disease was associated with reduced type 1 reaction risk vs multidrug therapy, with no increase in erythema nodosum leprosum. ja.ma/43OAMLg

Listen to Luc Thomas, MD, PhD, speak about the accuracy of #AI models for #SkinCancer diagnosis with Adewole S. Adamson, MD, MPP. 🎧: ja.ma/4vsLJhs

💬 Editorial: As more pathogenic #Melanoma variants are identified, updated evidence-based screening and management protocols are needed to guide clinical care. ja.ma/4vll2LC

Pathogenic variants in major familial #Melanoma genes were found in 0.5% to 0.9% of the general population, and >2.5% among those with multiple or early-onset #CutaneousMelanoma. ja.ma/49sMRt4

Neoadjuvant capecitabine led to tumor regression in 67% of patients and a complete pathologic response in 42% of surgically treated cases with advanced #CutaneousSquamousCellCarcinoma of the head and neck. ja.ma/3RU1M9u

A clinical prediction model for #PemphigusVulgaris using hoarseness, dysphagia, and disease severity accurately predicted deep laryngeal involvement and may help guide laryngoscopy decisions. ja.ma/4dU0nHd

Individuals with #ChronicLymphocyticLeukemia faced increased risk of skin cancer-specific metastasis and death compared with controls especially #BasalCellCarcinoma and #SquamousCellCarcinoma, though the absolute risk remained low. ja.ma/4ucGDox

#AI-assisted dermoscopy matched or exceeded dermatologist performance for #Melanoma detection in prospective studies, but broader clinical validation is needed for routine use. ja.ma/4dU7I9Q

A woman in her 40s with a medical history of complex regional pain syndrome presented to the dermatology department for evaluation of a pruritic recurrent rash on her right anterior thigh that started 1 month prior. Take the Clinical Challenge: ja.ma/3PVFsf7

In 2025, JAMA Dermatology evaluated >3,400 manuscript submissions and maintained an Impact Factor of 11. Read the full “JAMA Dermatology—The Year in Review, 2025,” by Editor in Chief Kanade Shinkai, MD, PhD. ja.ma/4dvqENe

Combined therapy with ixekizumab and tirzepatide led to higher rates of complete skin clearance and ≥10% weight reduction at 36 weeks in adults with moderate to severe #Psoriasis and #overweight or #obesity. ja.ma/49kStp8

Global burden of melanoma, cutaneous squamous cell carcinoma, and basal cell carcinoma increased from 1990 to 2023, with projections indicating further growth to 2050, especially in low- and middle-SDI regions. ja.ma/49Pw3fL

Isotretinoin use for #Acne in adolescence was not associated with reduced adult height in a nationwide cross-sectional study of Danish military conscripts. ja.ma/3PXH2Nx

Robert A. Swerlick, MD, discusses his research which defined the demographics, #SkinCancer risk factors, and near-term outcomes of asymptomatic individuals seeking comprehensive skin examinations with Adewole S. Adamson, MD, MPP. Listen now: ja.ma/4fvwFe6

Presented last week at #SIDCHICAGO26: Genetically diagnosed porokeratosis was associated with increased risk of #KeratinocyteCancer, especially squamous cell carcinoma, compared with matched controls, but not with melanoma. ja.ma/4uMy9VU

💬 Editorial: Adding incretin therapy to biologic treatment improved skin outcomes and cardiometabolic risk factors in patients with moderate to severe #Psoriasis and obesity. ja.ma/4ulgqVM

Presented last week at #SIDCHICAGO26: Combined therapy with ixekizumab and tirzepatide led to higher rates of complete skin clearance and ≥10% weight reduction at 36 weeks in adults with moderate to severe #Psoriasis and #overweight or #obesity. ja.ma/4wC4oZo

📄 This case report describes off-label intradermal hyaluronidase injections as a targeted antifibrotic treatment for a woman in her 50s with systemic sclerosis–related sclerodactyly. ja.ma/3RBYJ5C

Global burden of melanoma, cutaneous squamous cell carcinoma, and basal cell carcinoma increased from 1990 to 2023, with projections indicating further growth to 2050, especially in low- and middle-SDI regions. ja.ma/4eKsGdu