New preprint by @merenbey.bsky.social, where they validate long-read metagenome assemblies by aligning reads to contigs, and find TERRIFYING levels of errors. I'm honestly shocked. I have papers in review with conclusions based on metaMDBG assemblies. What now? www.biorxiv.org/content/10.1...

My metagenomics group spends tens of TB storing BAM files. I made a CLI tool to strip unneeded data from BAM/SAM files. We see 90-98% lower file sizes, with identical downstream results. Get it at: github.com/jakobnissen/... #metagenomics #bioinformatics #rustlang