Growing evidence shows that sleep disruption is a feature of primary headache disorders. A new systematic review found reduced sleep efficiency, increased night-time awakenings, and altered arousal patterns in migraine, with emerging similarities in cluster headache. Read: doi.org/10.1186/s101...

New real-world data show effectiveness of eptinezumab in difficult-to-treat migraine patients. In a multi-centre study, ~70% of patients achieved a ≥50% reduction in migraine days within 6 months, with major improvements in disability and quality of life. Read more: doi.org/10.1186/s101...

New preclinical evidence strengthens the link between CGRP and migraine-associated photophobia. CGRP induced light avoidance and headache-like pain in rats, closely mirroring human migraine provocation studies, offering strong translational relevance for studying migraine. doi.org/10.1186/s101...

In a collaboration with Headache, Cephalalgia has published a series of 2025 highlights reflecting on a year of milestones across migraine and headache research. These highlights cutting-edge work in headache medicine. Read from the collection here: journals.sagepub.com/doi/full/10....

This latest study reports the real-world data on medication-overuse headache from Egypt. A preventable cause of chronic headache with major impact on patients’ lives, especially in low- and middle-income settings: Read more: lnkd.in/eVWzaWja #Migraine #JournalOfHeadacheAndPain #MedicationOveruse

A recent study introduces the “four dimensions (4D) migraine scale,” a composite tool that integrates key clinical and patient-centered features to better quantify migraine severity and treatment response. journals.sagepub.com/doi/10.1177/...

A new systematic review and meta-analysis from researchers on behalf of the European Headache Federation (EHF)—evaluates long-term (≥12 months) safety of monoclonal antibodies targeting the CGRP pathway for migraine prevention. doi.org/10.1186/s101...

A comparative 7 T multimodal MRI study shows that migraine with aura is associated with distinct subcortical nuclei alterations and glymphatic dysfunction compared to migraine without aura and healthy controls. 👉 doi.org/10.1186/s101...

A randomized, placebo-controlled crossover study found that sildenafil reliably induced headache but not migraine-like attacks in men with migraine without aura, contrasting with higher migraine induction in women. doi.org/10.1186/s101...

New research shows that spreading depolarizations can activate the cGAS–STING immune pathway, fueling inflammation and head pain linked to migraine with aura. The study also found that targeting this pathway may reduce pain responses in preclinical models. doi.org/10.1186/s101...

The Journal of Headache and Pain is now accepting submissions for the 2026 Early Career Research Mentorship Program. 🧠 PhD, Postdocs & Residents 📝 Original Research or Review 🏆 10 APC waivers ✨ Opportunity to join the Junior Editorial Board ⏰ Deadline: 31 Aug 2026 (or until awards allocated)

Thanks to everyone who joined us at the European Headache Congress 2025. Your support made the meeting unforgettable. 📸 Got photos? Tag us! We’d love to see your moments from the congress. 🌍 Planning ahead—2026 details coming soon. Keep an eye on our social channels and the website for updates.

The EHF School of Advanced Studies (SAS) meet at the Congress in Lisbon! 🧠✨ The SAS offers high-level training for early-career clinicians & researchers to deepen their expertise in migraine and headache medicine. Want to join the 2026 cohort? Keep an eye on the EHF website for updates.

Exciting news from the European Headache Congress in Lisbon! 🎉 Congrats to the newly elected European Headache Federation board members: 🇳🇱 Rolf Fronczek 🇹🇷 Esme Ekizoglu 🇷🇸 Igor Petrusic #EHC2025 #EHF #Neurology

📣 EHC 2025 Closing Ceremony! We are thrilled to announce that the European Headache Congress (EHC 2026) will be held in the magnificent city of Berlin (9-12 December 2026) Save the date! We can’t wait to see you there! #EHC2025 #Lisbon #ClosingCeremony #EHC2026 #Berlin #HeadacheCongress

Day 4: don't miss the session on Headache and Stroke, covering critical topics like Intracranial Hypertension and Cerebral Venous Thrombosis. #EHC2025 #Headache #Stroke #Neurology Follow us also on Instagram www.instagram.com/european_hea...

Day 3 has begun! The EHF School of Advanced Studies (SAS) is now LIVE at the Headache Theatre! #EHC2025 #SAS #Migraine

Join this afternoon at the European Headache Congress in Lisbon! 4pm in the Plenary Hall the European Headache Federation Award session. 17.15-18.45 the parallel sessions: Assessing outcomes in Headache Care and Basic Science of Headache. Or browse the ePosters. headache-congress.org #EHC2025

Starting NOW: Plenary Session 3 at EHC 2025! Focus is on Neurodegeneration in Chronic Migraine and new findings on Neuropeptides in TACs. Essential translational science! #EHC2025 #TranslationalViews #MigraineResearch

☀️ EHC 2025 Day 2: The Debate Heats Up! The second day of EHC 2025 is starting strong with a lively debate in the Future Headache Experts (FHE) session! 🔥 #EHC2025 #FHE #FutureHeadacheExperts #Comorbidities

🥂 EHC 2025 Day 1: Day 1 is officially wrapped, highlighted by our inspiring Opening Ceremony. The evening culminated in the presentation of the Lifetime Achievement Award to Professor Steiner. We thank all attendees for making today unforgettable. See you tomorrow! #EHC2025 #OpeningCeremony

Don't miss the Session on Headache Biomarkers at EHC 2025. Key insights on future diagnostics! #EHC2025

⚡️ NOW LIVE: Parallel Session 1! Tune in right now for Parallel Session 1: Headache and Hormones

EHC 2025: Plenary Session Kicks Off! The moment we've been waiting for is finally here! The European Headache Congress has officially begun! 🎉 #EHC25 #EHF #headache #migraine

Migraine and pregnancy-related headaches are independent risk factors for serious complications, including a significantly increased risk of stroke and other cardiovascular events during pregnancy and the postpartum period. Full details: doi.org/10.1186/s101...

Spreading Depolarization (SD) can trigger seizure-like activity in the hippocampus. This suggests a probable direct mechanism for migraine-aura triggered seizures (migralepsy). Read more: doi.org/10.1186/s101...

New findings link Familial Hemiplegic Migraine type 2 (FHM2) to a significantly impaired glymphatic system. This study identifies abnormal neurovascular coupling as a key factor, opening new avenues for understanding migraine pathophysiology. Read the full article: doi.org/10.1186/s101...

Abnormal brain iron deposition in patients with new daily persistent #headache (NDPH). Findings indicate that the metabolic disorder of iron deposition in specific areas of the brain may be related to the underlying pathogenesis of patients with NDPH. Full text here: rdcu.be/eOLcO

How common chronic headache disorders are and how much productivity loss they are causing within administrative bodies? Compared with TTH, #migraine compromises brain health more severely and generates more economic loss. Full text here: doi.org/10.1186/s101...

The International Headache Society’s new position statement highlights the importance of early migraine prevention. It recommends considering preventive therapy from 2–4 monthly migraine days and underscores the need for studies to evaluate early intervention benefits: doi.org/10.1177/0333...

New meta-analysis found no clear link between migraine and overall, cardiovascular, or suicide-related mortality. Some studies identified a link between women with migraine aura and increased cardiovascular risk, highlighting the need for more research and sex-specific risks doi.org/10.1186/s101...

Women with migraine show higher serum levels of CGRP, a key migraine-related molecule, compared to healthy controls. A CGRP level above 40 pg/mL was linked to more frequent attacks and greater pain sensitivity. Links between CGRP and rimegepant response were identified: doi.org/10.1186/s101...

New study: Men with migraine are much less likely than women to get the right diagnosis before seeing a specialist (57% vs 74%). Women often show classic migraine signs, while men have less typical symptoms—leading to missed or delayed care. doi.org/10.1186/s101...

🧠New insight into migraine and inflammation: results from a large systematic review and meta-analysis (57 studies, ~2 850 migraine patients) reveals that different inflammatory markers are associated with different migraine states. doi.org/10.1186/s101...

🧠 New research suggests a promising approach for post-traumatic headache (PTH) relief! doi.org/10.1186/s101...

This new meta-analysis reveals how the brain’s electrical activity changes across migraine phases in Hemiplegic migraine👇 ⚡ Aura: 71% show low-amplitude EEG on the opposite side of paralysis ⚡ Headache/Post-headache: slowing in the same region ⚡ Interictal: 79% normal EEG doi.org/10.1186/s101...

We have extended the late breaking abstract deadline to 10 October! Whether you are working on innovative treatments, new clinical data, or emerging insights in headache and migraine research, we want to hear from you. 📢 Submit your abstract today: headache-congress.org/programme-ab... #EHC25

Headaches are widespread but under-recognised in the German military: 95% had headaches last year, 27% migraine, 29% probable migraine. 64% lost workdays; migraineurs ~4 days/month. Most had no diagnosis & few used preventives. Better screening & care needed. Read more: doi.org/10.1177/0333...

Spreading depolarization triggers migraine-like facial pain and anxiety in a model. Oral atogepant, a CGRP receptor blocker, reduces pain and eliminates grimace responses, while also improving anxiety-like behavior, highlighting its potential for migraine treatment. doi.org/10.1186/s101...

New methods in awake models are improving our understanding of spreading depolarization, key in migraine with aura. Techniques like optogenetics, wireless telemetry, and two-photon imaging enable minimally invasive, long-term monitoring, bridging the gap to human studies. doi.org/10.1186/s101...

📢 Call for Papers – Journal of Headache and Pain Submit your work to our new collections: 🧠 Pain in Neurodegenerative Diseases 🧬 Epigenome & Transcriptome in Headache 💊 Community Pharmacy & Headache Care Help shape the future of headache research. 🔗 thejournalofheadacheandpain.biomedcentral.com

Epigenetic changes in the RONS-TRPA1-CGRP pathway may shape migraine susceptibility, chronification, and treatment response. Insights from a narrative review. doi.org/10.1186/s101...

🔬 New Tool in Migraine Care: The “CGRP Score” Nomogram. This ML-based predictive score achieved a good performance in identifying responders to anti-CGRP mAbs. The nomogram has the potential to be a practical, user-friendly tool for supporting clinical decision-making. doi.org/10.1186/s101...

🤖💡 AI is reshaping how we approach headache care. A systematic review of 76 studies highlights progress in diagnosis, treatment prediction, and digital health monitoring. But major challenges remain. So, AI should augment—not replace—the doctor–patient relationship. doi.org/10.1186/s101...

This year’s programme features high-level plenaries, cutting-edge debate sessions, interactive teaching courses, and forward-looking updates – all under the theme “Transforming Challenges into Solutions”.

Late breaking abstracts are open – perfect for those last-minute discoveries! You have groundbreaking results or fresh insights to share? Submit your late breaking abstract now & showcase your latest research to a global audience. 🗓️ Deadline: 29 September 2025 🔗 headache-congress.org/programme-ab...

Established molecular triggers reliably induce extracerebral arterial dilation, an effect reversed by sumatriptan. These findings support the hypothesis that sustained meningeal vasodilation might contribute causally to #migraine pathogenesis. Read more here: rdcu.be/eCJA3

Longitudinal assessment of #migraine burden in resistant and refractory migraine – Data from the prospective REFINE study. While both ResM and RefM reflect high migraine disability burden, they might present relevant differences in their management and prognosis. rdcu.be/eB8lD

Trigeminal neuralgia affects brain-wide networks—not just facial pain areas. Patients show reduced brain flexibility and control, especially with age. Evidence suggests it is a whole-network disorder, not a local one. Read the article: doi.org/10.1186/s101...

In a mouse model of post-traumatic headache, anti-CGRP mAb partly reduced pain if given around injury—but fully blocked it if given before headache triggers. Timing matters! Read the full study: doi.org/10.1186/s101...