Migraine and Meniere’s disease show high comorbidity and shared symptoms. A recent study provides new insight of a shared genetic and cellular basis between the two conditions. Using GWAS and single-cell analyses, researchers identified overlapping risk genes. Read: doi.org/10.1186/s101...

Neuropathic pain remains notoriously difficult to treat, the mechanisms driving it are still unclear. A recent preclinical study highlight a compelling link between metabolism and pain and suggest the FGF4/HIF-1α axis as a potential target for future therapies. Read: doi.org/10.1186/s101...

What exactly should be considered a “migraine day”? A new international study proposes a consensus-based definition, developed through expert agreement, to help standardize migraine research and clinical practice. ➡️ doi.org/10.1186/s101... #Migraine #HeadacheResearch #Neurology

This new study examined whether network-level BOLD-CSF coupling alterations were differentially distributed across migraine subtypes and whether such alterations were associated with a deep learning estimation of the brain age gap. ➡️ doi.org/10.1186/s101...

Data from RCT (eptinezumab vs placebo) showed more favorable improvements in eptinezumab in multiple patient-reported outcomes (PROs) capturing headache-related life impact. ➡️ doi.org/10.1177/0333...

A pilot study suggests that pharmacist-led migraine consultations may enhance patient education and self-management, highlighting a potential role for community pharmacies in migraine care as a complement to existing headache care pathways. doi.org/10.1186/s101...

Structural brain MRI changes following 6 months of preventive treatment with erenumab or onabotulinumtoxinA in migraine. 📖 Read the article: doi.org/10.1186/s101...

Breaking the medication overuse headache cycle: from nociplastic pain mechanisms to patient-centered interventions. Reframing MOH within a nociplastic pain framework supports a shift from rigid detoxification models toward personalized, mechanism-based, and multidisciplinary care. rdcu.be/fh6gp

Understanding how pain and emotional symptoms are linked remains a major challenge in headache research. A recent preclinical study sheds light on a specific cortico-thalamic circuit that may play a key role in this connection. Read more: lnkd.in/e6qvnr-R

📢Call for Papers – The Journal of Headache and Pain 📢 Exciting opportunities to contribute to upcoming thematic collections in The Journal of Headache and Pain: Headache & Sustainable Development Goals, Focus India and Chronobiology of Headaches. See more: link.springer.com/journal/1019...

Migraine and fertility treatments: what’s the link? This systematic review explores how assisted reproductive technologies and hormonal interventions may influence headache disorders. 📖 doi.org/10.1186/s101...

Research published in The Journal of Headache and Pain explores the role of biochemical markers—such as CGRP, cytokines, and mitochondrial factors—in children with migraine. doi.org/10.1186/s101...

A large systematic review shows that migraine may be associated with an increased risk of retinal vascular events and macular disorders. 🧠 👁️‍🗨️ 📖 Read the full article: doi.org/10.1186/s101...

A recent systematic review in Cephalalgia examines current clinical guidelines for managing migraine in children and adolescents. 🔍 The study underscores the need for more pediatric-focused research and updated, harmonized guidelines to improve care. 📖 Read more: doi.org/10.1177/0333...

A recent study in The Journal of Headache and Pain explores how epigenetic changes may play a role in migraine and medication overuse headache, and how these patterns evolve after medication withdrawal. 📖 Full article: doi.org/10.1186/s101...

Forecasting #migraine with time-series machine learning from mobile health data. The most important features were #headache intensity, duration of the headache, and heart rate scores. Open access: link.springer.com/article/10.1...

Shift work #migraine disorder (SWMD): evidence, mechanisms, and implications for diagnosis, prevention, and management. Open access: link.springer.com/article/10.1...

A prospective study examined fluid biomarkers in idiopathic intracranial hypertension to better understand pathophysiology. The authors measured serum and CSF proteins and explored their relationship with intracranial pressure and visual outcomes. Read the study: doi.org/10.1186/s101...

A new neuroimaging study examined differences between migraine with depressive symptoms and migraine without. Brain dynamics distinguished the two groups, highlighting the potential for dynamic imaging biomarkers to identify migraine subtypes and guide treatment. Read: doi.org/10.1186/s101...

A recent cross-sectional study of over 1,000 students from China highlights the high burden of headache disorders in children and adolescents and their links to lifestyle factors. Migraine and tension-type headache were common, yet only 8% had sought medical care. Read: doi.org/10.1186/s101...

A new neuroimaging study explored the biology of medication-overuse headache in chronic migraine. The authors found reduced iron in the brains of chronic migraine patients with medication overuse headache. Lower iron was also associated with higher relapse rates. Read online: doi.org/10.1186/s101...

A new paper published in Journal of Headache and Pain dissected the genetic relationship between temporomandibular disorders (TMD) and anxiety. TMD genetic risk includes both anxiety-related (~20%) and anxiety-independent components, with distinct biological pathways. doi.org/10.1186/s101...

🧠 Fractal dimension analysis of cortical MRI morphology can differentiate individuals with episodic migraine from healthy controls, suggesting that subtle alterations in cortical structural complexity may serve as potential imaging biomarkers of migraine. ➡️ doi:10.1177/03331024251414616

A new review in The Journal of Headache and Pain explores the premonitory phase of primary headaches, highlighting shared and distinct mechanisms between migraine and cluster headache. ➡️ doi.org/10.1186/s101...

A recent study shows that Nr4a1 (nuclear receptor subfamily 4 group A member 1) modulates microglial overactivation and neuroinflammation in a rat model of trigeminal neuralgia. ➡️ doi.org/10.1186/s101...

🚨 Can blocking oxytocin receptors trigger a migraine attack? New research shows that acute oxytocin antagonism doesn't provoke attacks, suggesting a more complex modulatory role for this hormone. 🧠✨ doi.org/10.1186/s101...

70 enthusiastic young doctors took part in the new School of Headache Essentials (SHE) – the first meeting on 20 February 2026 in Vilnius, Lithuania, was a great success! 🎉 Applications to host an SHE meeting will be accepted from 6 March. ➡️ www.ehf-headache.org/.../school-o....

Hypothalamic and sex-related #hormones in #migraine. This review highlights the interplay between sex/reproductive hormones and hypothalamic hormones and their receptors in migraine-related neural structures. Open access: link.springer.com/article/10.1... #medicine #neurology #headache

Interictal burden, not ictal burden, drives work productivity impairment in #headache disorders: insights from a Japanese cross-sectional study. Open access: link.springer.com/article/10.1... #neurology #migraine #medicine #burden

Growing evidence shows that sleep disruption is a feature of primary headache disorders. A new systematic review found reduced sleep efficiency, increased night-time awakenings, and altered arousal patterns in migraine, with emerging similarities in cluster headache. Read: doi.org/10.1186/s101...

New real-world data show effectiveness of eptinezumab in difficult-to-treat migraine patients. In a multi-centre study, ~70% of patients achieved a ≥50% reduction in migraine days within 6 months, with major improvements in disability and quality of life. Read more: doi.org/10.1186/s101...

New preclinical evidence strengthens the link between CGRP and migraine-associated photophobia. CGRP induced light avoidance and headache-like pain in rats, closely mirroring human migraine provocation studies, offering strong translational relevance for studying migraine. doi.org/10.1186/s101...

In a collaboration with Headache, Cephalalgia has published a series of 2025 highlights reflecting on a year of milestones across migraine and headache research. These highlights cutting-edge work in headache medicine. Read from the collection here: journals.sagepub.com/doi/full/10....

This latest study reports the real-world data on medication-overuse headache from Egypt. A preventable cause of chronic headache with major impact on patients’ lives, especially in low- and middle-income settings: Read more: lnkd.in/eVWzaWja #Migraine #JournalOfHeadacheAndPain #MedicationOveruse

A recent study introduces the “four dimensions (4D) migraine scale,” a composite tool that integrates key clinical and patient-centered features to better quantify migraine severity and treatment response. journals.sagepub.com/doi/10.1177/...

A new systematic review and meta-analysis from researchers on behalf of the European Headache Federation (EHF)—evaluates long-term (≥12 months) safety of monoclonal antibodies targeting the CGRP pathway for migraine prevention. doi.org/10.1186/s101...

A comparative 7 T multimodal MRI study shows that migraine with aura is associated with distinct subcortical nuclei alterations and glymphatic dysfunction compared to migraine without aura and healthy controls. 👉 doi.org/10.1186/s101...

A randomized, placebo-controlled crossover study found that sildenafil reliably induced headache but not migraine-like attacks in men with migraine without aura, contrasting with higher migraine induction in women. doi.org/10.1186/s101...

New research shows that spreading depolarizations can activate the cGAS–STING immune pathway, fueling inflammation and head pain linked to migraine with aura. The study also found that targeting this pathway may reduce pain responses in preclinical models. doi.org/10.1186/s101...

The Journal of Headache and Pain is now accepting submissions for the 2026 Early Career Research Mentorship Program. 🧠 PhD, Postdocs & Residents 📝 Original Research or Review 🏆 10 APC waivers ✨ Opportunity to join the Junior Editorial Board ⏰ Deadline: 31 Aug 2026 (or until awards allocated)

Thanks to everyone who joined us at the European Headache Congress 2025. Your support made the meeting unforgettable. 📸 Got photos? Tag us! We’d love to see your moments from the congress. 🌍 Planning ahead—2026 details coming soon. Keep an eye on our social channels and the website for updates.

The EHF School of Advanced Studies (SAS) meet at the Congress in Lisbon! 🧠✨ The SAS offers high-level training for early-career clinicians & researchers to deepen their expertise in migraine and headache medicine. Want to join the 2026 cohort? Keep an eye on the EHF website for updates.

Exciting news from the European Headache Congress in Lisbon! 🎉 Congrats to the newly elected European Headache Federation board members: 🇳🇱 Rolf Fronczek 🇹🇷 Esme Ekizoglu 🇷🇸 Igor Petrusic #EHC2025 #EHF #Neurology

📣 EHC 2025 Closing Ceremony! We are thrilled to announce that the European Headache Congress (EHC 2026) will be held in the magnificent city of Berlin (9-12 December 2026) Save the date! We can’t wait to see you there! #EHC2025 #Lisbon #ClosingCeremony #EHC2026 #Berlin #HeadacheCongress

Day 4: don't miss the session on Headache and Stroke, covering critical topics like Intracranial Hypertension and Cerebral Venous Thrombosis. #EHC2025 #Headache #Stroke #Neurology Follow us also on Instagram www.instagram.com/european_hea...

Day 3 has begun! The EHF School of Advanced Studies (SAS) is now LIVE at the Headache Theatre! #EHC2025 #SAS #Migraine

Join this afternoon at the European Headache Congress in Lisbon! 4pm in the Plenary Hall the European Headache Federation Award session. 17.15-18.45 the parallel sessions: Assessing outcomes in Headache Care and Basic Science of Headache. Or browse the ePosters. headache-congress.org #EHC2025

Starting NOW: Plenary Session 3 at EHC 2025! Focus is on Neurodegeneration in Chronic Migraine and new findings on Neuropeptides in TACs. Essential translational science! #EHC2025 #TranslationalViews #MigraineResearch

☀️ EHC 2025 Day 2: The Debate Heats Up! The second day of EHC 2025 is starting strong with a lively debate in the Future Headache Experts (FHE) session! 🔥 #EHC2025 #FHE #FutureHeadacheExperts #Comorbidities

🥂 EHC 2025 Day 1: Day 1 is officially wrapped, highlighted by our inspiring Opening Ceremony. The evening culminated in the presentation of the Lifetime Achievement Award to Professor Steiner. We thank all attendees for making today unforgettable. See you tomorrow! #EHC2025 #OpeningCeremony