Mariarosaria De Rosa (@meryderosa.bsky.social)

I am excited to share that our study has just been published in Nature Communications! www.nature.com/articles/s41... We uncovered a “dark side” of base excision repair of oxidative guanine damage at telomeres. 🧵⬇️

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OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced senescence in human fibroblasts - Nature Communications Telomeres are prone to oxidative damage, particularly the formation of the common lesion 8-oxoguanine. This study shows that the processing of 8-oxoguanine at telomeres by the DNA repair enzymes OGG1 ... https://www.nature.com/articles/s41467-024-55638-4