Mihovil Joja
@mihojoja.bsky.social
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MD, PhD student in Mahesh Desai lab in Luxembourg. Studying mucin-degrading bacteria in IBD.
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Mihovil Joja
Marion Brunck
3 months ago
⏰ Timing is everything 🦠 as you will appreciate listening in! 🤓Keep abreast of the literature as
@kknoop.bsky.social
gives a round up summary of the review that inspired the latest
@mucosalimmunol.bsky.social
cover and guess the disease/pathogen with
@ashu-mangalam.bsky.social
‘s Med Mystery 🎧
add a skeleton here at some point
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Mihovil Joja
Mucosal Immunology
3 months ago
Our August issue is online now
www.mucosalimmunology.org/current
, featuring microbes that are “living on the edge” from Mahesh Desai
www.mucosalimmunology.org/article/S193...
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Mihovil Joja
Lisa Maier Lab | Tübingen
4 months ago
Finally online! Our latest research is out
@nature.com
: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
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Non-antibiotics disrupt colonization resistance against enteropathogens
Nature - Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of...
https://rdcu.be/ewwrG
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Mihovil Joja
Lisa Maier Lab | Tübingen
5 months ago
Ever wondered why proton pump inhibitors raise the risk of C. diff infections? Is it due to pH shifts or direct antibacterial effects on the gut microbiome? We think it’s the pH. 🧪💡 Dive into Julia & Patrick’s new paper for the full story! 📖👇
#Microbiome
#PPI
doi.org/10.1080/1949...
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Proton-pump inhibitors increase C. difficile infection risk by altering pH rather than by affecting the gut microbiome based on a bioreactor model
Clostridioides difficile infections often occur after antibiotic use, but they have also been linked to proton-pump inhibitor (PPI) therapy. The underlying mechanism – whether infection risk is due...
https://doi.org/10.1080/19490976.2025.2519697
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Mihovil Joja
Dirk-Jan Scheffers 🟥
5 months ago
It’s a bacterium-eats-bacterium world…
www.science.org/doi/10.1126/...
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Bacteria poison and eat their neighbors
Bacteria leverage a secretion system to kill and scavenge nutrients from nearby competitors
https://www.science.org/doi/10.1126/science.ady7008?utm_source=sfmc&utm_medium=email&utm_content=alert&utm_campaign=SCIeToc&et_rid=34820745&et_cid=5641210
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Mark A. Hanson
5 months ago
To celebrate this (urp 🤢) exciting new journal series, we made a mini game! Can YOU guess which journals are Discover, MDPI, or both? No cheating! There's even the challenge mode "APC Ladder." Share your high score with the hashtag
#ResearchIntegrity
pagoba.shinyapps.io/publi_guess/
FUN!! 🤮 6/n
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Itai Yanai
6 months ago
Have you discovered the Night Science Podcast yet?
@nightsciencepod.bsky.social
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Thomas Clavel
6 months ago
Very happy that HiBC is out:
rdcu.be/ekSCO
🔥
@natcomms.nature.com
Excellent team spirit, and, as always, great driving factor by
@tcahitch.bsky.social
⭐⭐⭐⭐ We hope that these bacterial isolates from the human gut will facilitate many studies by others... 😀
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HiBC: a publicly available collection of bacterial strains isolated from the human gut
Nature Communications - Here, the authors present and characterise a collection of human gut bacteria including novel taxa associated with health conditions and a large diversity of plasmids. All...
https://rdcu.be/ekSCO
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Mihovil Joja
Lisa Maier Lab | Tübingen
7 months ago
Here are our ideas on developing tools and technologies for anaerobic bacteria! We hope you enjoy the read as much as we enjoyed brainstorming on the topic...
add a skeleton here at some point
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Mihovil Joja
Microbiology Society
7 months ago
Our "Guide to communicating microbiomes in the media", created in collaboration
@lindsaybroadbent.bsky.social
aims to help navigate the complexities of communicating microbiome research. Click the link in our bio to read and download the guide.
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Mihovil Joja
Nature Microbiology
7 months ago
Out now! Live bacteria can translocate to other tissues via Colonic goblet cell-associated passages which may be beneficial to the host!
#MicroSky
#MicrobiomeSky
🦠
www.nature.com/articles/s41...
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Colonic goblet cell-associated antigen passages mediate physiologic and beneficial translocation of live gut bacteria in preweaning mice - Nature Microbiology
Colonic goblet cell-associated passages allow translocation of live bacteria to other organs in early life, potentially leading to beneficial impacts.
https://www.nature.com/articles/s41564-025-01965-1?utm_source=bluesky&utm_medium=social&utm_campaign=nmicrobiol
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Mihovil Joja
George Birchenough
8 months ago
My colleague Sjoerd van der Post just quietly dropped a preprint defining the interaction of the
#ETEC
SPATE family enzyme EatA with intestinal Muc2, providing some fascinating insights into host specific
#mucus
degradation 🤯. Check it out:
www.biorxiv.org/content/10.1...
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Degradation of the intestinal mucus layer by the ETEC protease EatA is species specific determined by the structure of the MUC2 mucin
Enterotoxigenic Escherichia coli (ETEC) infections are a leading cause of diarrheal illness, responsible for an estimated 100,000 deaths annually. ETEC pathogenesis is driven by various virulence fact...
https://www.biorxiv.org/content/10.1101/2025.03.16.643548v1.full
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Mihovil Joja
Nature Microbiology
8 months ago
A very helpful read on tackling procrastination
@naturebiotech.bsky.social
www.nature.com/articles/s41...
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An open letter to graduate students and other procrastinators: it’s time to write - Nature Biotechnology
Nature Biotechnology - An open letter to graduate students and other procrastinators: it’s time to write
https://www.nature.com/articles/s41587-025-02584-1
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Mihovil Joja
Nature Microbiology
9 months ago
A must-read for any microbiome researcher 🦠📐and a new addition to our
#bestpractices
series Planning and describing a microbiome data analysis by
@amydwillis.bsky.social
and
@davidandacat.bsky.social
www.nature.com/articles/s41...
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Planning and describing a microbiome data analysis - Nature Microbiology
We provide guidance on the planning, execution and description of statistical analyses in microbiome studies.
https://www.nature.com/articles/s41564-025-01944-6?utm_source=bluesky&utm_medium=social&utm_campaign=nmicrobiol
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Mihovil Joja
Oded Rechavi
9 months ago
IT'S HAPPENING! The Woodstock of Biology 2.0 meets Night Science
@nightsciencepod.bsky.social
10-13 of June in Prague & the Woods of Bohemia... Be there or be REJECTED.
#theconferencetoendallconferences
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Mihovil Joja
Nature Microbiology
9 months ago
OUT NOW: SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome
@harriswang.bsky.social
& co
www.nature.com/articles/s41...
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SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome - Nature Microbiology
Split-And-pool Metagenomic Plot-sampling sequencing (SAMPL-seq) can be applied to complex microbial communities to reveal spatial co-localization of microbes at the micron scale.
https://www.nature.com/articles/s41564-024-01914-4
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Mihovil Joja
Nature Microbiology
9 months ago
OUT NOW: Carbohydrate-active enzymes from Akkermansia muciniphila break down mucin O-glycans to completion
@lucyicm.bsky.social
@cassiebakshani.bsky.social
#microsky
🧪
www.nature.com/articles/s41...
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Carbohydrate-active enzymes from Akkermansia muciniphila break down mucin O-glycans to completion - Nature Microbiology
Biochemical characterization of 66 carbohydrate-active enzymes from the gut microorganism Akkermansia muciniphila reveals that these enzymes can break down a range of host glycans, including mucin, wh...
https://www.nature.com/articles/s41564-024-01911-7
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Mihovil Joja
Eduardo Villablanca
10 months ago
Dear mucosal immunologists! Registration for the European Mucosal Immunology Group (EMIG) meeting in Aachen, Germany is now open. Register and see you this July in Aachen! 👇🏼
emig2025.de
@petterbrodin.bsky.social
@wiag.bsky.social
@mucosalimmunol.bsky.social
@societymucosalimm.bsky.social
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Mihovil Joja
bioRxiv Microbiology
10 months ago
Ten species comprise half of the bacteriology literature, leaving most species unstudied
https://www.biorxiv.org/content/10.1101/2025.01.04.631297v1
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Mihovil Joja
Nature Microbiology
10 months ago
OUT NOW: Metagenomic immunoglobulin sequencing (MIg-seq) reveals IgA coating of microbial strains in the healthy human gut by Justin Sonnenburg, Matt Olm, Sean Spencer & co
#microsky
www.nature.com/articles/s41...
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Metagenomic immunoglobulin sequencing reveals IgA coating of microbial strains in the healthy human gut - Nature Microbiology
Metagenomic immunoglobulin sequencing (MIg-seq) uncovered patterns of IgA antibody binding of bacterial strains in the healthy human gut microbiome.
https://www.nature.com/articles/s41564-024-01887-4
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Mihovil Joja
The BMJ
11 months ago
Surgeons showed significantly greater manual dexterity compared with physicians, nurses, and non-clinical staff when assessed using a buzz wire game. But had the highest rates of swearing
www.bmj.com/content/387/...
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Mihovil Joja
Hutlab
11 months ago
We are happy to announce that the MaAslin3 manuscript is now available on @biorxivpreprint! Check it out and feel free to post feedback on our forums!
www.biorxiv.org/content/10.1...
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MaAsLin 3: Refining and extending generalized multivariable linear models for meta-omic association discovery
A key question in microbial community analysis is determining which microbial features are associated with community properties such as environmental or health phenotypes. This statistical task is imp...
https://www.biorxiv.org/content/10.1101/2024.12.13.628459v1
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Mihovil Joja
Michael Fischbach
11 months ago
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream.
@djenetbousbaine.bsky.social
led the charge...
@natureportfolio.bsky.social
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Mihovil Joja
Bork Group at EMBL Heidelberg
11 months ago
Everyone talks about "strains", but what are they? Within the lab, we often come back to the review "Diversity within species: interpreting strains in microbiomes" by Thea Van Rossum (2020) when discussing at which phylogenetic resolution we do see different signals
www.nature.com/artic...
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Diversity within species: interpreting strains in microbiomes
Nature Reviews Microbiology - Large-scale metagenomic analyses are vastly increasing the rate of discovery of variation within species but they are also leading to scientific and semantic...
https://www.nature.com/articles/s41579-020-0368-1
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