Rianne Lord (@drriannelord.bsky.social)

Late to the party, but... Congratulations to the group on the latest @pubs.acs.org in Inorganic Chemistry! Thanks for your efforts Tam and Ben 🙏🏼 Thanks also to Dr Ceyda Acilan and her team for the continued collaboration 🙏🏼🎉🥂 pubs.acs.org/doi/10.1021/...

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Understanding the Modes of Action of β-Ketoiminato Iridium(III) Complexes in Cancer Cells Four new charged iridium(III) 1,2,3,4,5-pentamethylcyclopentadienyl (Cp*) complexes, 1–4, of the type [Cp*Ir(L1–4)(PTA)](PF6) (where L1–4 = functionalized β-ketoiminate ligands and PTA = 1,3,5-triaza-7-phosphaadamantane), have been successfully synthesized and characterized. Single crystal X-ray crystallographic data have been obtained for all compounds and confirm a typical pseudo-octahedral half-sandwich geometry. Cytotoxicity values have been determined against a range of cancerous and noncancerous cell lines and highlight high cytotoxicity and selectivity toward breast cancers. Among these compounds, the unfunctionalized β-ketoiminate Ir(III) complex (1) emerged as the most promising candidate, demonstrating activity that was comparable to or exceeded that of cisplatin, especially after 24 h against the triple-negative MDA-MB-231 cell line. Morphological and molecular analyses confirmed that 1 triggers apoptotic cell death, involving caspase activation and PARP cleavage, which is consistent with its DNA-damaging characteristics, highlighting the future anticancer potential of compound 1. https://pubs.acs.org/doi/10.1021/acs.inorgchem.5c02026