Anne Vassalli (@annevassalli.bsky.social)

Our follow-up study on the orexin↔dopamine neuronal interplay is here to share! We discover opposite action of #hypocretin/orexin A vs B via #OX1R vs #OX2R on VTADA cell excitability +demonstrate striking distinct impact of DA cell Ox1 vs 2R loss on mouse behavior in socioemotional&cognitive domain

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Divergent modulation of dopaminergic neurons by hypocretin/orexin receptors-1 and -2 shapes dopaminergic cell activity and socio-emotional behavior Many neuropsychiatric disorders involve dysregulation of the dopaminergic (DA) input to the forebrain. Of particular relevance are DA projections originating from the midbrain ventral tegmental area (... https://www.biorxiv.org/content/10.1101/2025.02.14.638329v1