Depression isn’t one thing. 🚨 Same label. Different brain states. Different drivers. Different treatment responses. New video 👉Depression Isn’t One Thing - Why the Wrong Treatment Keeps Failing youtu.be/-AvODpgp8OQ

Supplements for ADHD?🚨 Top 5 solutions to specific bottlenecks. Each one maps to a different problem:
1. a dopamine limiting step
2. signal-to-noise regulation
3. membrane signalling efficiency
4. timing (circadian delay)
5. effort physiology / cognitive endurance Names 👇 youtu.be/hYwGWx1UNLI?si…

Serotonin enters the ADHD conversation. 🚨 New video on Centanafadine, a triple reuptake ADHD medication (NE + DA + 5-HT) that’s now under FDA Priority Review. Video 👉 youtu.be/DKWGO3BzFCI

Why Hyperbolic tapering of antidepressants may be making things worse 🚨 We’re told the safest way is : Go slower. Hyperbolic taper. Micro-reduce. And for many people, that’s true. BUT What if, in some cases, the tapering process is the issue? Video 👉 youtu.be/oZxe_EkgXP8?si…

One of the most common psychiatric interventions I implement in clinical practice is Iron Supplementation. 🚨 Cos… Brain iron ≠ serum iron. This matters in ADHD management In this video, I link iron to clinical practice (ADHD and RLS) Video 👉 youtu.be/vf7ol8mpZjk?si…

New video 🚨 I cover: 1. The transformation trap (relief ≠ function) 2. The cue–reward trap (when meds become the reward) 3. What stimulants actually do: improve signal clarity, not motivation Video 👉 Here’s What ADHD Stimulants Actually Do. (Why Calm Isn’t Enough) youtu.be/4c-AICHiBuc

New video👇Why AfterSun Broke Me “Brought me to tears. Beautifully said and I related so much. Bittersweet.” “Beautiful video. I had a very similar experience watching it, and watching this analysis. …… Brilliant.” youtu.be/0YyX22DygFE

𝐓𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭 𝐫𝐞𝐬𝐢𝐬𝐭𝐚𝐧𝐭”… 𝐨𝐫 𝐣𝐮𝐬𝐭 𝐭𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭 𝐰𝐢𝐭𝐡𝐨𝐮𝐭 𝐝𝐢𝐫𝐞𝐜𝐭𝐢𝐨𝐧 ? 🚨 In this new video, I cover: 1. Why treatments appear to “fail” when the brain has no clear prediction 2. The 3 questions for specific, testable targets 3. Why function is the real marker of progress Video 👉 youtu.be/Vi9Opuvwk4s?si…

New Video 🚨👉telling people to “exercise”… for many, that advice backfires. It’s movement , not exercise, that regulates the brain. I cover 👇 • why motivation comes after action • the brain pathways that help people get started • a simple movement script Watch video 👇 youtu.be/NntTyHygGNU

🚨Is this the worst question in psychiatry? “How’s your mood?” ⁉️ Clinically, it tells us almost nothing. “Mood” is not a feeling, not happiness, and not sadness - but something far stranger: A rolling measure of prediction success vs failure. 🎥 New video 👉 youtu.be/zUkm8jR6BM8

New video 🚨 Modafinil vs Armodafinil I cover: -How they work on dopamine, norepinephrine, orexin & histamine -Role in narcolepsy, shift work, sleep apnoea, depression & ADHD -The idea of “performance debt” -Side effects, and risks Watch here👉 youtu.be/J3nzq2GIPUo

If you deal with "chronic pain", this video will give you something to think about.

New video 👉Why Chronic Pain Persists: Neurobiological Mechanisms 🚨 I cover: 👉Why pain persists after tissues heal 👉Central sensitisation, neuroinflammation, descending inhibition 👉conceptualising pain beyond nociception.. the human aspects Video 👉 youtu.be/ovMOmAbxbkQ?si…

New video. 🚨 -Not about Ritalin or Dex. -Not about making a child sit still or focus harder This is about a core neurobiological system the Brain needs - and the one modern childhood has systematically ‘stripped’ away. The System is PLAY Here’s why it matters 👉 youtu.be/PwmTLNUTWZQ?si…

Very interesting. We know insufficient sleep reduces stimulant effectiveness, and once addressed this improves most cases where patients report medications seems less effective. Will have to start incorporating adenosine into those discussions. /1

New video 🎥 The Dopamine Paradox🚨 “Doesn’t last long enough … Not as strong” Seeing more patients on increasingly higher stimulant doses, sometimes above recommended limits … 🚩 But when doses keep needing to go up, that’s a red flag clinicians need to notice. 👇 Link 👉 youtu.be/qYfrHCbGbbU?si…

Procrastination Isn’t Laziness — It’s a Dopamine Timing Glitch (and Here’s How to Fix It) youtu.be/slwjAIaePPU

Kratom Explained: Stimulant, Opioid, or Danger? 🚨 Kratom is marketed as a natural remedy - but its effects are not without risks. I break down:
 👉Pharmacology 👉Short & Long Term Effects 👉Regulatory action and more... 
 Link 👉 youtu.be/rEjIVyJsANM?... #Kratom

AuADHD & Stimulants 🚨 Ever had patients with ASD + ADHD respond atypically to stimulants? “Makes me tired” “I was anxious.” I cover: -Why the ‘autistic brain’ processes stimulants differently -Clinical signs to watch for -Strategies to improve outcomes Video 👉 youtu.be/dLVzwNp9GMY?si…

𝐍𝐞𝐰 𝐫𝐞𝐥𝐞𝐚𝐬𝐞 🎥 𝐏𝐚𝐭𝐢𝐞𝐧𝐭𝐬 𝐨𝐟𝐭𝐞𝐧 𝐬𝐚𝐲: “𝐈 𝐣𝐮𝐬𝐭 𝐜𝐚𝐧’𝐭 𝐬𝐰𝐢𝐭𝐜𝐡 𝐨𝐟𝐟.”🚨 In this video, I explore the Default Mode Network (DMN) - the brain’s “overthinking circuit.” Video 👉 youtu.be/JWpxycc6iKQ?si…

Interoceptive Awareness and its role in ADHD and ASD ‘Burnout’ 🚨 Interoceptive awareness is the brain’s ability to detect and integrate internal bodily signals Video 👇 youtu.be/ONM8YifTjf4 In ADHD & Autism, brain regions like the insula or ACC can misread or miss key physiological signals.

Interoceptive Awareness and its role in ADHD and ASD ‘Burnout’ 🚨 Interoceptive awareness is the brain’s ability to detect and integrate internal bodily signals Video 👇 youtu.be/ONM8YifTjf4

“Wired… and tired.”🚨 Often mislabelled as anxiety, this state is frequently driven by noradrenergic hyperarousal In this video, I explore: – The difference between anxiety, hyperarousal & agitation – The circuits involved -A 4-step practical framework Video 👇 youtu.be/PHLSQVuNxv4?...

The average age of first porn exposure is just 11.*🚨 In this video, I explore: 1. How porn ‘hijacks’ dopamine & motivation 2. Brain changes 3. Hypersexual disorder & POPU 4. Evidence-based treatments *range of surveys show ages between 10-13

The Most Expensive Debt of All? Understanding Burnout as Performance Debt 🚨 In this video, I cover the neurobiology and strategies to start paying it back - clinically and practically 👇 🔗 👉 youtu.be/AP_GTgslEPM?si…#Burnoutu#PerformanceDebtb#MentalHealthth

New video 🚀- RFK Jr. went viral using methylene blue mid-flight. 🚨 But few realise what he was really taking. In this video, I explain: – MOA – Dose-response & psychiatric implications – Biohacking myths vs clinical pharmacology – What clinicians & patients need to know youtu.be/qDYzyq1WcyM

New video 🚨5 psychiatric phenomena so strange, they blur the line between reality and delusion. 🚀 5 Bizarre Psychiatric Syndromes You Won’t Believe Are Real youtu.be/k6-VJ1c77QM

New video on the Dr Rege channel: 🚀 Still Tired After 10 Hours of Sleep? - Let’s try to Solve it …🚨 In this video, I go beyond diagnostic labels to take a problem-solving approach to fatigue. 🔗 Watch here 👇 youtu.be/TxC1WCtugBc #Fatigue #Burnout #Neuroscience

High Achiever but Always Burnt Out? Hidden ADHD… or Survival Mode? youtu.be/AtERZ0Rw5gA

🚨 New video on the Dr Rege Channel - Emotions as a signal 🎥 Emotions come from ‘emovere’- “to move out”. They’re not problems to fix, but signals pointing to unmet needs and prediction mismatches. 🔗 👉 youtu.be/h7cEnI3atFE?si…

New video 🚨👉You're Not Treating a Label- You're Treating a Human ✅ Give me 5 minutes-and it might change the way you approach treatment. If you don’t define the targets, you’re flying blind- no matter how “right” the diagnosis seems. Here’s how to change that 👇 Video 👉 youtu.be/0TINiQeot3M?si…

🚨 NEW - ADHD and Non Stimulants 🚀 ADHD meds = dopamine-spiking stimulants. But is it hiding a long-term price? I break down the non-stimulant options- from atomoxetine to a med that slashed symptom scores by ~50%. Video 👉 youtu.be/I0JGVNWTZsM?si… *General education only #adhdh#stimulantsts

Antidepressants are just like heroin.🚨 That’s the claim. And it’s dead wrong - in two completely different ways. I break it down: – What real addiction is – Why SSRI withdrawal ≠ addiction – The dangers of lazy science Video 👇 youtu.be/_kVPN6goeTw

The Overlooked Reason ADHD Treatment Fails - Fix This First youtu.be/5giC7Hh0AmA

New Video🚀 This topic often flies under the radar yet frequently arises in clinical practice, particularly in addiction & sexual health settings. Chemsex involves complex intersections of trauma, stigma, substance use, and mental health. Clinicians should be aware. 👇 Video : youtu.be/kdbS22vBYzA

New video : Exploring ‘The Substance’ through a psychodynamic lens: 👉The split self and identity diffusion 👉Role absorption 👉Repetition compulsion 👉An insight into borderline personality organisation 👉Cyclical Psychodynamics youtu.be/OLp9zocvcQ8

A visual guide to metabolic switching 👉https://youtu.be/NDV-AlCfBYc?si=4h1welf3sbg_jeow

New video on YT I cover : 1. The gut-brain connection 2. Inflammatory vs. anti-inflammatory diets 3. Evidence for Mediterranean & ketogenic diets 4. Nutrients for serotonin, dopamine production 5.Practical steps to ‘support your brain’ with food youtu.be/TPY-rB4N3V0

🧠 What Happens to Your Brain Without Sleep?🚨 3 Days Without Sleep—Here’s What Happens Next 👉 youtu.be/NY4oNQd-xeY

15 Commandments of Psychopharmacology 🚀 Textbooks taught me psychopharmacology-UNTIL I stepped into real-world practice as a consultant psychiatrist. 🚨 Here’s what experience taught me that textbooks don’t (or can’t).

🚀 New YT video out! 👉 youtu.be/q_5hZUnmsI4?si… The Neuroscience of intermittent fasting and how, from an evolutionary perspective, our brains evolved to experience metabolic switches- which may offer neuroprotective and cognitive benefits.

@drsanil.bsky.social and @realjesseluke.bsky.social, this happened soon after I fell asleep and I suspect was the combo of low-level clonidine from a much earlier dose, lemborexant, and the elevated/stimulated state empagliflozin puts me in. A state that the lemborexant brings to an end after 3 days

🎥New Video Release on Psychiatry Simplified: Understanding Anhedonia 🚨 youtu.be/lTvdGFJeAMM

New YT video - Not All SSRIs Are the Same! 🚨 youtu.be/_vITGe0XxuI 👉Receptor profiles & metabolism – Why some SSRIs are activating, others sedating 👉Drug interactions & CYP inhibition 👉Withdrawal risks – What to monitor 👉Patient-tailored selection – Matching SSRI pharmacology to symptom profile

🧵The Stability Paradox in BPD: Why Attention-Seeking Is Not What You Think 🚨 Most misunderstand attention-seeking in BPD. Let's break it down 👇Thread on Twitter X x.com/sanilrege/st...

New Video: NAC in Psychiatry –Evidence, Mechanisms & Clinical Use 🚀 N-acetylcysteine (NAC) is one of the few supplements with a reasonable evidence base across psychiatric disorders, including schizophrenia, depression, OCD, bipolar disorder, and addiction. Video 👉 youtu.be/CfHJGR8NXeE

x.com/sanilrege/st... Great thread on BPD and restricted access to care by @drsanil.bsky.social

Psychedelics and the Free Energy Principle ( FEP) 🍄- Video👇 A while ago, someone asked “explain the Free Energy Principle to a 5-year-old.” Video 👉 youtu.be/CgkGjKKyyf8 Enjoy the ride! 🚀🐛🧠

Is ADHD Overdiagnosed ? A Nuanced Exploration 👇 youtu.be/rdmdpMlmU-Q?...

Coming up tomorrow on The Psychiatry Simplified Channel 🚀 Why is ADHD on the Rise? 🚨 You can subscribe ( or hit the bell icon) to be notified 👇 www.youtube.com/@psychiatrys...