❓Tech Q&A | Band misalignment in #WB is usually technical, not antibody-related. 👉Common causes: • Uneven gel #polymerization from poor mixing • Air bubbles in gel affecting migration • Sample-buffer interference alters mobility • Overloading samples #WesternBlot #LabTroubleshooting

❓Tech Q&A | SR-18292 may fail to inhibit #PGC1α due to insufficient dose and short exposure. 🔎Reported studies use higher concentrations (~20 μM) and longer incubation 👉Try extending treatment time and expanding the dose range 📑PMC: 7399350; PMC: 10093564 #SR18292 #WesternBlot #WB #Troubleshooting

📚Compared with conventional CAR-T, #InVivo #CART generates cells directly in patients, bypassing ex vivo steps for a faster, cheaper, off-the-shelf solution—covering comparisons, tech platforms, gene #delivery, and clinical progress & challenges. ow.ly/oJS050Y4GOt

🌍World Cancer Day | A new study from Cell reframes #cancer as a multidimensional system shaped by: 🔬Cancer cell traits 🧬Enabling characteristics 🧫The tumor microenvironment 🌐Whole-body influences 🧐Learn more: file.medchemexpress.com/pdf/MedChemE... #WorldCancerDay #TumorMicroenvironment

🎨Science Visuals | CAR-T Cell Therapy at a glance With new targets, smarter designs, and solid tumor strategies emerging, CAR-T remains a key focus in immuno-oncology. 👀Looking forward to innovative updates at the #ASTCT Tandem meeting! #Tandem26 #CART

🚀From Bench to Paper | A Cell study used Exendin-4 and #Exendin (9-39) amide (MedChemExpress) to clarify role of GLP-1 signaling in appetite and glucose regulation. Synergistic activation of #gut enteroendocrine cells⬆️hormone secretion + #metabolic benefits. #Metabolism #GLP1

❓Tech Q&A | p-PERK can appear as either a single band or a doublet in #WB due to post-translational modifications, including different phosphorylation states. ✅Both patterns are commonly reported and considered normal under #ER stress conditions. #pPERK

🚀From Bench to Paper | A Nature Genetics study maps all functional #FGFR 1–4 kinase mutations via saturation mutagenesis, revealing activating & drug-resistant variants for precision #oncology. #Puromycin (MedChemExpress) supported high-throughput screening. www.medchemexpress.com/Puromycin.html

🦠#NipahVirus (#NiV) is a deadly #zoonotic virus (40–75% fatality) with no approved treatment or vaccine. Recent outbreaks in Asia drive urgent antiviral & vaccine research. #VV116 shows promise. We support NiV research with 200+ compound libraries & 30,000+ bioactive compounds. ow.ly/iQI850Y4aEr

📰New & Featured | #NipahVirus Alert 🦠A high-risk #zoonotic disease under global surveillance: NipahVirus (#NiV) has a 40–75% fatality rate and no approved treatment or vaccine. How does spread? Animal → Human, Foodborne transmission, Human → Human. ow.ly/kfOU50Y3CwI

🚀From Bench to Paper | 🌟A study from Immunity shows how #redox regulation shapes immune cell metabolism & #ferroptosis tolerance. Using TRi-1 (#TXNRD1 inhibitor, MedChemExpress), the team uncovered links between redox balance, lipid #metabolism, and #immune cell survival. #Tri1

🔥Hot Off the Press | 🧬New Cell research reveals how class II #olfactory receptors can detect fatty acids and link chemosensation to downstream biological responses, shedding light on how organisms sense and respond to metabolic cues.

📰New & Featured | 🧬A new Cell study identified receptor #Or5v1/#Olfr110, senses #oxylipin signals and boosts liver fat burning and glucose control. ❓Could targeting such receptors become a new strategy against metabolic disease?👇 #obesity #antiobesity

🧫#CAGEs Power Live-Cell Single-Cell Genomics Single-cell sequencing is powerful but hard to scale in live cells. CAGEs(Capsules with Amphiphilic Gel Envelopes) retain cells & biomolecules while allowing reagents in, enabling high-throughput assays & genome-wide readouts.

💊FDA Approval Update | #SofetabartMipitecan Eli Lilly’s Sofetabart Mipitecan (#LY4170156) receives FDA Breakthrough Therapy designation for platinum-resistant #ovarian, fallopian tube, or primary peritoneal cancer. A #FRα-targeted #ADC carrying #exatecan, delivering therapy directly to cancer cells.

📚MedChemExpress Digest | #Macrophages Macrophages are key innate #immune cells in health & disease. Our practical guide covers: • Roles in immunity & tissue repair • How to induce subtypes #invitro • Markers & features to ID M1 vs M2 Learn more: ow.ly/FmJi50Y0tJz

Did you know @medchemexpress.bsky.social supplies a broad range of high-quality research chemicals and #biochemicals? 🧪🔬 Explore their compound screening libraries 👉 https://www.bioscience.co.uk/suppliers/medchem  #BioSky #DrugDiscovery

🔥Hot Off the Press | 🧐How T cells read antigen strength New Science study shows T cell activation isn’t just about signal intensity, but timing. 🔹#ERK signaling occurs in pulses 🔹Higher antigen affinity → more frequent ERK pulses 🔹T cells integrate these pulses over time to decide activation

📰New & Featured | A new Cell study discovered #CARD9 inhibitors with anti-inflammatory activity 🌟Blocks NF-κB and cytokine release in humanized CARD9 mouse model 💡A truncated variant of CARD9 has potential protective effect against Crohn's disease #HumanGenetics

🔥Hot Off the Press | 🧠New in Cell: Researchers bypass the #BBB by hijacking skull immune cells to deliver drug-loaded #nanoparticles directly into the #brain. 🐁In stroke models: ✔️Reduced brain damage ✔️Improved recovery ✔️Feasibility and safety ❓New route for #CNS delivery

📰New & Featured | 🧠Cell: How could #EBV help trigger #MS? A new Cell study shows that EBV-infected B cells can: 🧬Capture myelin antigens in the #CNS 🚫Bypass immune tolerance ⚡Trigger early demyelinating lesions #MultipleSclerosis #Neuroimmunology #EpsteinBarrVirus

✨#𝐃𝐞𝐜𝐞𝐦𝐛𝐞𝐫 𝐍𝐞𝐰 𝐑𝐞𝐥𝐞𝐚𝐬𝐞𝐬 🤩MedChemExpress launches 1,000+ new #molecules this December, supporting research across #Oncology, #Neurology, #Immunology & #Inflammation, and #Metabolic Diseases. Clearer targets. Greater control over mechanism validation.

📚Meet MedChemExpress Series | #FDAApprovals 2025 The U.S. FDA has approved 40+ novel drugs as of December 2025, covering #oncology, #RareDiseases, #neuroscience, infectious diseases, ophthalmology, and cardiovascular & metabolic disorders. Explore more: ow.ly/pOAW50XVgnX

🔥Low Bone Mass in Alzheimers Sensory nerves are essential for the skeletal stemcell (#SSC) niche. Loss of #p75NTR in sensory neurons disrupts SSC function, lowers neuronal osteopontin (#SPP1), and drives bone loss in #Alzheimers (#AD). ow.ly/oN7e50XVgcA

📰New & Featured | 🚀#NEJM: Universal base-edited #CD7 #CART cells show strong activity in relapsed/refractory T-ALL ✔️ Deep remissions ✔️ Bridge to allo-#HSCT ✔️ Off-the-shelf potential #TCellAcuteLymphoblasticLeukemia #CAR7 #BECAR7

🔥Hot Off the Press | How do #PDAC cells survive extreme stress? #NF2 & #Merlin Loss Fuels PDAC Survival 🔸In PDAC: NF2 loss → Merlin loss → cancer cells survive low nutrients & hypoxia → increased invasiveness, therapy resistance, & nutrient scavenging via #macropinocytosis.

🔥Hot Off the Press | 🧬CAR-T struggles in solid tumors because expression ≠ suitability. This preprint shows how AI + safety-by-design can: 🧬Rank antigens contextually 🔐Guide logic-gated CARs 🤖Assist design without sacrificing safety www.biorxiv.org/content/10.6...

🔥#meTPD–Driven Cancer #Vaccine #iVAC degrades #PDL1, drives tumor antigen presentation, and reprograms cells into APC-like messengers. Awakens bystander memory #Tcells, turning cold tumors hot—robust CD8⁺ activation & superior tumor control in humanized mice & organoids. #TPD

🔥 Hot Off the Press | Mitochondrial #VHL Rewires Cell Metabolism in Hypoxia Under chronic low oxygen, von Hippel-Lindau (VHL) translocates to #mitochondria, binds #MCCC2, and reprograms leucine & glutamine metabolism to support cell growth. Linked to VHL mutations in cancer.

📰New & Featured | Single-donor human #iPSC-derived lung-on-chip (#iLoC) 🔸Mimics lung 3D mechanical stretching + air-liquid interface 🔸Recapitulates cellular profiles in distal lung 🔸Macrophage #necrosis was higher upon #ATG14 deficiency after Mycobacterium tuberculosis (#Mtb) infection #LungOnChip

📰New & Featured | #Cell: #GPX4 released during #ferroptosis binds to dendritic #ZP3, activating cAMP-PPKA signaling 🔸Inhibits #glycolysis 🔸Impairs DC maturation and activation 🔸Eventually results in T cell priming defect 🧐Blocking GPX4-ZP3 interaction potentially drives #antitumor activity

🔥Hot Off the Press | A Cell study reveals the cryo-EM structure of pancreatic human islet amyloid polypeptide (#hIAPP) and atomic structure of pathological hIAPP fibrils. 🧐This can advance our understanding of mechanisms and therapeutic exploration in type 2 #diabetes (#T2D).

📰Extrachromosomal DNA (#ecDNA) drives cancer evolution and relies on ATM-mediated #DNAdamage response (#DDR) for replication and maintenance. TOP1, TOP2B, and the #altNHEJ pathway play key roles. Targeting ATM-DDR may offer new therapeutic opportunities for ecDNA+ tumors.

🔥#Ferroptotic cancer cells release #GPX4 as an immunosuppressive damage-associated molecular pattern. GPX4 binds #ZP3 on dendritic cells, blocks DC–T cell priming, and dampens antitumor immunity. Targeting the GPX4–ZP3 axis boosts responses to chemo-, radio-, and immunotherapy.

A fin-loop–like structure in #GPX4 anchors the enzyme to cell membranes, protecting neurons from #ferroptosis.A Cell study showed that a single point mutation (p.R152H) disrupts this protection, leaving neurons vulnerable to lipid peroxidation—especially in children with early-onset #dementia.

📰#AI-Guided #BreastCancer Therapy HR+/HER2− breast cancer is ~2/3 of cases. After CDK4/6i resistance, options are limited. The LINUX trial shows AI can classify tumors from routine H&E slides to guide therapy. In 105 advanced patients, AI-guided treatment improved outcomes & PFS.

📰New & Featured | T cell engagers (#TCE) are bispecific antibodies (#BiTEs) that transiently reprogram #CTLs to eliminate target cells 👉High response rates with step-up dosing to manage side effects 👉Aims for smarter targeting and better safety #BispecificAntibodies #Immunotherapy

🧬#Sefaxersen targets complement #FactorB mRNA, reducing FactorB and blocking the alternative pathway. Now in Phase3 IMAGINATION, this #RNAtherapy offers high specificity, long-acting effects, and potential disease-modifying benefits for kidney disease. #Kidney #PrecisionMedicine

📰New & Featured | A simplified haplo-#HSCT conditioning regimen (Flu/Cy + PTCy) shows promise in severe aplastic #anemia, avoiding ATG & irradiation 🔹To potentially reduce regimen-related toxicity 🔹Simplify the #transplant preparation while maintaining engraftment 🔗Read more:

📚#Aging drives chronic diseases, with 1 in 5 people expected to be 60+ by 2050. Explore the 14 #hallmarks of aging, mechanisms from molecules to systems, and emerging ways to clear senescent cells or slow aging. Discover more: ow.ly/wiuc50XSi3O

💜New year, same research goals… time to set them again with Cece! Wishing all researchers a strong start to 2026—smooth experiments, robust data, and a fulfilling research journey ahead. MedChemExpress is here to continue supporting your work every step of the way. 🌱 #newyear #researchlife #lablife

💊FDA Approval Update | #FDA recently approved #Yartemlea (#Narosoplimab-wuug) for #hematopoietic stem cell #transplant (#HSCT)-associated thrombotic microangiopathy 🔸Inhibits #lectin pathway effector enzyme — #MASP2 #HematopoieticStemCell #ThromboticMicroangiopathy

🧬Molecule of the Moment | Rather than controlling movement speed/force, dopamine provides a baseline permissive signal for movement to occur. 🔸#Levodopa alleviates #Parkinson's-induced motor symptoms by upregulating brain dopamine levels. 🌟We provide Levodopa for research use.

📰New & Featured | #Nanobodies Nanobodies—tiny, stable, highly specific single-domain antibodies—are transforming cancer diagnosis and therapy. From targeted #drugdelivery and advanced imaging to CAR-engineered #immune cells, they offer #precision beyond conventional antibodies. ow.ly/4Y4H50XRPF5

🤝 MedChemExpress on the Move A little throwback to bustling booths, brilliant conversations, and unforgettable connections. Thanks to everyone who stopped by, shared ideas, and shaped the journey with us. 👋 🌍 See you in 2026 💜 #Conference #LifeSciences #DrugDiscovery #ResearchTools #BoothVisit

📂The folder is bouncing—packed with MedChemExpress products! Referenced in 80,000+ #publications, fueling science and accelerating discoveries worldwide. 🎉Thank you for your support in 2025—we’re excited for what’s ahead in 2026. Happy New Year! 💜 #ResearchCitations #LabTools

📰New & Featured | A new #Cell study reports how the helicase-primase (H/P) complex of #HSV1 can be structurally inhibited 🧐Explains #antiviral potency and resistance mechanisms 💡Opens new avenues for next-generation anti-HSV therapies #HelicasePrimaseComplex #UL30

🔥Hot Off the Press | A #Science study reveals that #dermatomyositis is driven by JAK1-mediated, monocyte-induced #vasculopathy and #inflammation 🌟#JAK1 blockade mitigates endothelial damage and inflammatory signatures 💡JAK1 can be a promising target for dermatomyositis

🔥Tumour-enriched amino acid mimic drives in situ assembly of #PROTACs and immune-engaging #nanoparticles, boosting #Tcell activation 14.8× and causing strong tumour regression with minimal toxicity. ow.ly/WKzy50XQhjE #Tumour #CancerResearch #Immunotherapy #Nanomedicine

🤝MedChemExpress on the Move | Wrapping Up 2025 with MedChemExpress✨ 🌟#Tbt to bustling booths, brilliant conversations and unforgettable connections🧪💬🌍 💜Thanks to everyone who stopped by, shared ideas, and shaped the journey with us. See you in 2026👋 #EndOfYear #Science #LifeScience #2025 #2026