💊#FDAApproval Update | The FDA has approved a label expansion for #TREMFYA (#guselkumab), making it the only IL23 inhibitor proven to help inhibit progression of structural joint damage in active psoriatic arthritis (#PsA). Phase3b APEX trial: ✔️A 57% decrease in the rate of radiographic progression

🧫 Advanced organoid–immune co-culture platforms, including #ALI systems and microfluidic chips, are improving in vitro modeling of the #TME and tumor–immune interactions.Models are accelerating research on immune evasion, immunotherapy response, and personalized cancer treatment. ow.ly/MqnP50Z50wm

💊#FDAApproval Update | The FDA has approved #DECNUPAZ (#pivekimab_sunirine-pvzy) for adults with blastic plasmacytoid dendritic cell neoplasm (#BPDCN) 🧬DECNUPAZ: #CD123-targeting antibody-drug conjugate (#ADC) 💡The therapy delivers a cytotoxic payload directly to CD123-expressing tumor cells

🔥Heart regeneration in advanced #HeartFailure NEJM #BioVAT-HF Phase 1–2 explores #iPSC-derived heart muscle patches 🫀 Early signals: engraftment, vascularization, coupling → potential regeneration 🌱 MCE supports regenerative medicine with #GMP-grade stem cell workflow reagents. ow.ly/ksO150Z51Bm

TCR-T therapy is an emerging cancer immunotherapy targeting intracellular antigens via MHC presentation, showing promise especially in solid tumors. Key challenges remain: target specificity, safety, and the immunosuppressive tumor microenvironment. ow.ly/Znac50Z4zIs

🧬#Organoids reveal a human menstrual cycle model in vitro (#IVMC), recapitulating endometrial breakdown & regeneration without scarring. WNT7A marks a regeneration-associated epithelial state, and regenerating epithelium coordinates with endothelial cells to drive tissue repair.

💊#FDAApproval Update | The FDA has approved #Datroway (#datopotamabderuxtecan), the first TROP2-directed antibody-drug conjugate (#ADC) for first-line treatment of unresectable/metastatic triple-negative breast cancer (#TNBC) in patients ineligible for PD-1/PD-L1 therapy #BreastCancer

Can stress granules control ferroptosis? This study links stress granules to ferroptosis in glioblastoma stem cells (GSCs), which are resistant to IR/TMZ. Disrupting stress granules or using ciwujianoside C3 restores ferroptosis and resensitizes GSCs to therapy in vitro and in vivo.

🐘Lab Life | POV: negotiating with your blot like it’s going to listen 🤝🧫 #WB #WesternBlot

🔥 Human-Centric Drug Development Animal models fall short for next-gen therapeutics (oligonucleotides, ADCs, TPDs) due to human-specific biology. 🧬 Review highlights a shift to NAMs: 1️⃣ 🧫 human cell systems2️⃣ ⚙️ microphysiological systems3️⃣ 🤖 AI modeling → More predictive, human-relevant drug discovery.

🧬Wegovy (#Semaglutide) #ECO2026 data show benefits beyond weight loss in women with obesity across menopause stages: ↓ weight/waist, improved metabolic health, ↓ migraine/depression risk, ↓ CV events (MI/stroke). STEP UP & SELECT + real-world evidence support broad cardiometabolic & QoL benefits.

#SNOR Awakens Dormant Ribosomes Researchers uncover SNOR, a ribosome-associated factor licensing dormant eukaryotic ribosomes for rapid restart upon glucose return. Using in situ cryo-ET, they show SNOR binds with #eIF5A to reboot protein synthesis. These findings define a ribosome restart module.

Nb-PROTAC enables broad-spectrum anti-influenza by degrading viral proteins instead of inhibiting them. Nanobody–VHL targets conserved NP (H1–H16), suppressing multiple IAV strains. AAV-lung delivery shows strong in vivo protection. 🦠Programmable antiviral platform for next-gen influenza control.

❓Tech Q&A 🔸Most studies use disulfiram in the nM range in RAW264.7 cells (25–100 nM), while μM doses may be cytotoxic 🔸1h pretreatment + 24h palmitic acid exposure may increase cumulative stress 🔸DMSO concentration 🔸Lower both drug dose and final DMSO percentage 📃Refs: PMID: 25928135; 32001710

💊#FDA Approval Update | AstraZeneca’s #baxdrostat (#Baxfendy) for resistant/uncontrolled #hypertension. 💡Baxdrostat introduces a first-in-class approach by selectively inhibiting #CYP11B2 to suppress aldosterone production, a key #hormonal driver of elevated blood pressure. #PharmaNews

🧬Molecule of the Moment | TRI-611, #MolecularGlue degrader selectively eliminates #ALK fusion proteins, including #TKI-resistant variants 🔹Active against resistance mutations 🔹CNS-penetrant 🔹Phase 1/2 🌟Explore TRI-611 from MedChemExpress: www.medchemexpress.com/tri-611.html #DrugDiscovery #NSCLC

🎨Science Visuals |#Bundibugyo #Ebola Virus Disease (#BVD) ⚠️Symptoms: Fever, fatigue, muscle pain, progressing to vomiting, diarrhea, and bleeding in severe cases 🧪MCE offers Ebola-related tools for research use only: medchemexpress.com/search.html?... #EbolaOutbreak #PublicHealth #InfectiousDiseases

💭Things We Don’t Say in the Lab | 🔬What’s one thing you thought would be easy in lab work… but turned out to be surprisingly difficult? Could be: 🧫Keeping cells “happy” 📊Reproducing published data 🧪Optimizing one stubborn experiment ⏳Managing timing in the lab What caught you off guard the most? 👇

🔬New Releases | 1,000+ Research Molecules Now Available We’re excited to launch 1,000+ new MCE compounds across #Cancer, #Neurology, #Immunology and #Metabolic research. Includes tools for apoptosis, ferroptosis, ion channels, inflammation & metabolism, with improved drug-like properties.

🚀Repurposing antivirals: from #Measles to #Nipah Can a measles drug fight Nipah virus? A study shows #ERDRP0519 inhibits Nipah RdRp via a conserved binding pocket 🧬 New derivatives (GL22, G671) improve potency by enhancing steric effects during RNA synthesis ⚙️

💜Lab Life | POV: Lab intrusive thoughts hit different… ☀️ 🧊Honestly, the ice machine is becoming the most tempting thing in the lab lately. 😺Oddly satisfying though #LabLife #ResearchLife #ScienceHumor #POV #LabReel #BenchScientist #SummerMood

🎨Science Visuals | #PCOS to #PMOS — #PolyendocrineMetabolicOvarianSyndrome Reflects a growing recognition that the condition affects: 🔹Hormonal imbalance 🔹Metabolic dysfunction 🔹Mental health 🔹Cardiometabolic risk Aims to support: ✅Earlier diagnosis ✅Whole-body treatment approaches

💊#FDA Approval Update | #Vepdegestrant (#Veppanu) approved for advanced/metastatic breast cancer 🔸A first-in-class #PROTAC that goes beyond inhibition, driving degradation of its target protein. 🚀A validation of an entirely new therapeutic modality. #BreastCancer #Pharma #MedicinalChemistry

💊#FDA Approval Update | #Zenocutuzumab-zbco (#Bizengri) for adults with advanced, unresectable or metastatic #cholangiocarcinoma harboring an #NRG1 fusion after prior systemic therapy 🌟We offer zenocutuzumab for research use only: www.medchemexpress.com/zenocutuzuma... #CancerResearch #Oncology

🔥 RAS molecular glues vs resistance KRAS/NRAS/HRAS mutations keep signaling “on.” New TCIs block RAS–RAF, but resistance emerges fast. KRAS mutations → reduce binding or boost RAS–RAF interaction. BRAF alterations → stabilize RAF dimers 🔁Net result: signaling is restored via different escape routes.

🌍Magic Cece’s World Tour | Happy Weekend！ Did you know Cece is full of hidden talents? Playing guitar on the grass, soaking in the sunshine, and enjoying a quiet, relaxed moment outside the lab.☀️ Wishing you a smooth week in the lab and a wonderful weekend ahead! ✨

💙#WorldOvarianCancerDay | May 8 #NoWomanLeftBehind: a global call for equity, earlier diagnosis, better treatment access, and stronger support for every woman affected by ovarian cancer worldwide. 🌟We support #ovariancancer research with high-quality tools: www.medchemexpress.com/disease-area...

Oral #GLP1RAs regulate eating via brain circuits. Affect energy balance + reward feeding 🍽️ Central amygdala activation ↓ dopamine in nucleus accumbens → less hedonic eating. Links appetite & reward. Implications for obesity, binge eating & addiction-related behavior.

❓Tech Q&A • No reported studies on intrathecal use → safety/feasibility unclear • As a PEGylated aptamer, CNS delivery may differ from small molecules • If attempted: can be dissolved in DMSO, inject ~1–2 μL (monitor neurotoxicity) • Include dose-ranging groups to determine optimal concentration

Research suggests even subtle body movements (like abdominal muscle contraction while standing/walking) may slightly shift the brain and help promote cerebrospinal fluid flow, potentially aiding waste clearance. Mouse studies+modeling point to a possible “hydraulic pump” effect via vascular pressure

#Hantavirus is a rodent-borne zoonotic virus. A cruise ship cluster has raised concern, with WHO confirming 7 cases. The index case may have been infected before boarding, with possible spread to close contacts; limited human-to-human transmission cannot be ruled out.

💊FDA Approval Update | #Auvelity for #dementia-associated #agitation 📢The first non-antipsychotic therapy ✨ Moving beyond antipsychotics ✨ Targeting #NMDA & σ1 pathways 🧪MedChemExpress offers high-quality tools for #Alzheimer's disease-related research: www.medchemexpress.com/disease-area...

❓Tech Q&A • Dissolve in ddH₂O • Do not add directly to medium→low uptake • Use transfection reagent for in vitro delivery • Working range: 10-200 nM (start ~50 nM mimic, ~100 nM antagomir) • Nanometer-sized oligos→pass 0.4 μm filter easily • Antagomirs mainly optimized for in vivo use #miRNA

📚MedChemExpress Digest | Parkinson's Disease (#PD)🧠 #PD is a chronic, progressive #neurodegenerative disorder that imposes a growing global health burden, characterized by motor/non-motor, and cognitive symptoms. Key research directions: 🔬#TargetDiscovery 🧪#DiseaseModeling 🧬#Biomarker innovation

💊#FDA Approval Update | #Otarmeni™ (#lunsotogene parvec-cwha): The First-Ever Gene Therapy for Genetic Hearing Loss ✔️Genetic hearing loss linked to biallelic OTOF variants ✔️For pediatric/adult patients with severe-to-profound sensorineural hearing loss 📃Read more: www.fda.gov/news-events/...

At #AACR26, ADC development is rapidly advancing, with bispecific and dual-payload ADCs emerging as key innovations. MCE supports ADC research with 2,000+ products, Dual-payload products are also available in stock,with custom synthesis supported.🔗https://ow.ly/LHY750YQrtV🔗https://ow.ly/sp5h50YQstP

🚀Skin–Hypothalamus Axis & Heat Stress Heat stress triggers a skin–brain pathway: KLK14 reprograms hypothalamic astrocytes, suppresses PVN OXT neurons, and promotes visceral fat via the sympathetic system. Vitamin A lowers KLK14 and improves metabolic outcomes.

🤝MCE sponsored the joint meeting of #ACACR and #USCACA in San Diego. We delivered a keynote“By Scientists, For Scientists”, highlighting our scientist-driven approach to accelerating discovery. We supported the Joint Youth Awards, recognizing emerging scientists and fostering global collaboration.

🎯AACR 2026 | KRAS enters the “post-resistance” era • #Elisrasib: 12.2 mo mPFS in 1L NSCLC, CNS activity • #Zoldonrasib: G12D inhibitor, ORR 52%, ctDNA clearance 87% • #Daraxonrasib: 47% ORR in 1L pancreatic cancer 🔬MedChemExpress supports KRAS research: ow.ly/xY9m50YOjvX

📚MedChemExpress Digest | Tracing Tumor Metabolism with Single-Cell Metabolomics Key focus areas in this digest: 1️⃣ Single-cell metabolomics in tumor heterogeneity 2️⃣ Stable isotope tracing of metabolic flux 3️⃣ Case studies in tumor metabolic vulnerabilities ow.ly/qVYP50YNnAU

💊#FDA Approval Update | #IDVYNSO™ (#doravirine/#islatravir) approved as a once-daily #HIV1 treatment 🔸As the first non-#INSTI, #tenofovir-free complete regimen of its kind, this approval expands treatment options and highlights continued progress in antiviral innovation.

MCE New Releases | 1,000+ research molecules now available Expanding coverage across #Oncology, #Neurology, #Immunology, #Metabolism research to support diverse discovery needs. Targets include #BCL2, #KRASG12C, #PPARα, #5HT2A, #JAK/TYK2, and #METTL1—enabling deeper pathway exploration.

🤝MedChemExpress on the Move | #AACR 2026✨ 💜Cece and our team had a fantastic time at #AACR26, connecting with researchers and sharing ideas. Thank you to everyone who stopped by. We’re excited for more discoveries ahead! 🚀 #MedChemExpress @theaacr.bsky.social #AACR2026 #cancerresearch

🤝MedChemExpress on the Move | #IMMUNOLOGY2026 🌟 🐘The energy here is incredible! A big thank you to everyone who stopped by our booth and shared insightful discussions with us. We truly appreciate the engaging conversations and your continued interest in MedChemExpress. 💜 #AAI2026 #Conference

🚀BRD2 in Transcription Initiation #BRD2 maintains #RNAPolymeraseII at promoters via TFIID—especially when pause release is impaired. MOF-driven H4 acetylation enhances BRD2 chromatin binding & clustering. Disrupt this axis, and transcription collapses.Acetylation fine-tunes transcription initiation.

🎨Science Visuals | #Shigella Infection 🦠Shigella outbreaks can spread quickly due to its very low infectious dose. 🤢Symptoms include #diarrhea, cramps, fever, and dehydration. ⚠️Hygiene, food safety, and early response are critical to limiting spread. #ShigellaInfection #PublicHealth #Outbreak

📚MedChemExpress Digest | ADCs & Immune Synergy in Cancer Therapy In this article, we explore: 🔹Evolution of ADCs across three generations 🔹Mechanistic and strategic insights into ADC-based immune combination therapies 🔹Clinical advances & emerging therapeutic approaches ow.ly/c8W050YJMO0

📚ADCs& Immune Synergy in Cancer Therapy ADCs are evolving from precision drug delivery to immune-modulating therapies, increasingly integrated with immunotherapy for stronger anti-tumor effects. ADC evolution (3 generations); Immune combination strategies;Emerging clinical advances ow.ly/c8W050YJMO0

🤝MedChemExpress on the Move in the US | Join Us at #Immunology2026 📅 Date: April 15–19, 2026 📍 Venue: Boston Convention & Exhibition Center, Boston, MA, USA 🎪 Booth: #425 Let’s explore the latest in immunology research together! ow.ly/fjPc50YFt0Z #LifeSciences #Immunology #Biotech

🚀From Bench to Paper | A Nat Aging study reveals the mechanism behind resistance to platinum-based chemotherapy in lung and ovarian cancers 🔸Platinum therapies induce cellular #senescence 🔸Senescent cells secrete a TGFβ-enriched #SASP ⬆️Tumor progression/therapy resistance via #TGFβR1 and #AKT/#mTOR