@Bernard-S-Lopez.bsky.social (@bernard-s-lopez.bsky.social)

The hyper-activation of DNA double-strand break repair by the AKT1/PKB oncogene generates genetic instability. (A new role for the oncogene AKT1: the phosphorylation of MRE11). academic.oup.com/nar/article-...

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Genome rearrangements induced by the stimulation of end-joining of DNA double strand breaks through multiple phosphorylation of MRE11 by the kinase PKB/AKT1 Abstract. Genetic instability is a major hazard threatening the fate of cells and ultimately of organisms. DNA double-strand break (DSB) is a highly toxic https://academic.oup.com/nar/article-abstract/doi/10.1093/nar/gkaf468/8158035?utm_source=advanceaccess&utm_campaign=nar&utm_medium=email