A second email, this with a more substantial insight about "The Replication Crisis"... 1/5

I caught Covid and am working from home, perplexing our two cats. One comes to the door of the "office," sits outside, cries, is let in, and settles next to the desk. Then the other one repeats the process, causing the other cat to leave. I believe I have evidence of the Paw-li exclusion principle.

We view science as hypothesis testing, but where do hypotheses originate? From observing associations in systems we study—whether to fill known gaps or reveal the unexpected. SEAHORSE engineers serendipity—finding unexpected associations, beginning with GTEx and TCGA. www.biorxiv.org/content/10.1...

After a long journey, a paper by my colleagues @maudfagny.bsky.social, John Platig, and Katherine Stone was published today. It builds on our earlier work in eQTL networks and casts polygenic trait selection in the context of regulatory network models, shedding new light on the process. Take a look!

This is a nice overview of both my work and the impact of federal research cuts. I am at the point where I need to think about reinventing myself because we are watching the destruction of the research enterprise in the US. hsph.harvard.edu/news/how-doe...

The irrationality of the war on science that the Trump Administration has been waging manifests as indiscriminate termination of individual projects and whole lines of inquiry based solely on "bad words" appearing in their descriptions. #WarOnScience @statnews.com www.statnews.com/2025/04/23/u...

I'm a proud Harvard Professor, and the University stands behind academic freedom that powers discovery. Grants are not gifts; they are contracts on which we have to deliver. We work long, hard hours, train students, and return innovation and value to the US. #Harvard www.cnn.com/2025/04/17/u...

Our history of investment in funding biomedical research has positioned the US as the world leader, improved human health, trained generations of highly talented individuals who have founded biotech and lead pharmaceutical companies that employ tens of thousands. news.harvard.edu/gazette/stor...

I was interviewed by a local news channel about the disruptions in NIH funding. While the news story concentrates on the proposed reduction in facilities and administration costs, what they left out of the story is the significant risks of wider funding slowdown. www.boston25news.com/news/local/t...