One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential. www.biorxiv.org/content/10.1...

1/n 🧵 Excited to share our new paper! We developed a framework to reveal hidden simplicity in how organisms adapt to different environments, particularly focusing on antibiotic resistance evolution. #EvolutionaryBiology #MachineLearning

My NSF PRFB on the genetics of female polymorphism in hummingbirds was terminated yesterday. I don't have much to say, I'm just sad. We've discovered so much, and could have gone so much further. If anyone else is in the same boat, esp postdocs, please reach out, it would be good to connect.

1/ Hey y'all, I'm excited to share my latest paper, which is out now in PNAS! We introduce FAVA, a statistical framework to measure compositional variability across microbiome samples. If you want to measure variability across a stacked bar plot, FAVA is for you! Paper: doi.org/10.1073/pnas...

I’m thrilled to share my first ever publication, now published in PNAS! www.pnas.org/doi/10.1073/... With mentorship from the amazing @ksxue.bsky.social, I looked at how the outcomes of species introductions to microbial communities are influenced by the number of introduced microbes.

How is functional variation at large-effect loci maintained in natural populations? Thrilled to share our work showing how beneficial dominance reversal helps fruit flies maintain a resistance polymorphism as selection varies in their environment! A thread 🧵 1/n www.biorxiv.org/content/10.1...

To measure the selective and dominance effects of the resistant Ace alleles on fitness in a semi-natural context, we used Paul Schmidt & @petrovadmitri.bsky.social powerful system combining field mesocosms with large-scale phenotypic and genomic measurements (Rudman et al 2022) 9/n

Is it “winner-takes all” when the simplest living things compete? Check out my fresh publication on phage coexistence in Science and a thread below🧵 www.science.org/doi/10.1126/...

1st post on here to share our new preprint: ‘Metabolic similarity and the predictability of microbial community assembly’. Metabolically similar carbon sources lead to predictably similar growth rates and by-products which leads to predictably similar communities biorxiv.org/content/10.1... .