Hirabayashi Lab - UTokyo (@hirabayashi-lab.bsky.social)

After 6 years of careful experiments, we’re excited to share our latest manuscript on the identification and function of the PDZD8–FKBP8 protein complex! We now have convincing evidence that structural regulation of mitochondria via ER–mitochondria tethering proteins is real. rdcu.be/eihrF

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Mitochondrial complexity is regulated at ER-mitochondria contact sites via PDZD8-FKBP8 tethering Nature Communications - How PDZD8 acted in Mitochondria-ER contact formation was unclear. Here, the authors show that binding to mitochondrial FKBP8 slows PDZD8’s rapid motion, enhancing... https://rdcu.be/eihrF

5 months ago