@ahmad-ayadi.bsky.social
š¤ 27
š„ 96
š 185
Engineered stem cells whisper a soft chemical call, gathering protective cells to shield new islets in a gentle sanctuary. This harmony allows insulin to flow naturally, offering a future free from the heavy burden of lifelong immunosuppression.
pmc.ncbi.nlm.nih.gov/articles/PMC...
loading . . .
CCL22-expressing Stem Cellāderived Islet Grafts Recruit... : Transplantation
ed β-cells, potentially obviating the need for immunosuppressants. We hypothesized that SC-islets genetically engineered to secrete the chemokine C-C motif chemokine ligand 22 (CCL22) would attract Treg to the site of transplantation and may ultimately prolong graft survival. Methods. We engineered human embryonic stem cells to express CCL22 and differentiated them into SC-islets. CCL22+ SC-islets were assessed for gene and protein markers of endocrine cells and tested for function in vitro by glucose-stimulated insulin secretion assay, and in vivo by transplanting SC-islets into immune-deficient, streptozotocin-treated diabetic mice. Next, CCL22 bioactivity was confirmed by Transwell Treg migration assay. Treg migration was tracked using bioluminescent imaging of mice with CCL22+ SC-islet grafts and infused with luciferase-expressing Treg. Results. The expression of CCL22 did not adversely impact the differentiation into SC-islets, as confirmed by gene and protein analysis and functional tests in vitro and in vivo. CCL22+ SC-islets induced Treg migration in vitro, with specificity to CCL22 confirmed by a C-C motif chemokine receptor type 4 antagonist. Furthermore, CCL22+ SC-islet grafts recruited human Treg to the transplant site. Conclusions. CCL22+ SC-islets are functional and capable of attracting Treg. By recruiting Treg, CCL22+ SC-islets may create a tolerogenic immune environment for SC-islets after transplantation....
https://journals.lww.com/transplantjournal/fulltext/2026/01000/ccl22_expressing_stem_cell_derived_islet_grafts.18.aspx
about 9 hours ago
0
0
0
The Unfolding Path of Pancreatic Cells When the Acvr1b gene fades, both acinar and ductal cells lose their way and start forming tiny, fluid-filled cysts. This quiet change turns into a dangerous journey when inflammation acts as a spark to speed it up.
www.cmghjournal.org/article/S235...
loading . . .
Acvr1b Loss Increases Formation of Pancreatic Precancerous Lesions From Acinar and Ductal Cells of Origin
Pancreatic ductal adenocarcinoma can develop from precursor lesions, including pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasm (IPMN). Previous studies indicated that ...
https://www.cmghjournal.org/article/S2352-345X(24)00142-5/fulltext
about 9 hours ago
0
0
0
The Master Sculptor A Symphony of Timing TBX3 breathes life into promoters before softly weaving the liverās identity through precise enhancers.
www.cell.com/developmenta...
loading . . .
TBX3 advances the developmental chromatin landscape toward the hepatic fate
Stephan et al. characterize a dynamic chromatin landscape during the hepatic differentiation of induced pluripotent stem cells and identify TBX3 as being bound to liver-specific regions during the lin...
https://www.cell.com/developmental-cell/fulltext/S1534-5807(25)00325-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1534580725003259%3Fshowall%3Dtrue
about 24 hours ago
0
0
0
The Mirror on Chromosome 22 A 105 kb reverse flip creates a natural anchor that keeps the DNA stable. This elegant design is a hallmark of African ancestry, explaining a deep resilience that protects the heart of the genetic code.
www.nature.com/articles/s41...
loading . . .
Population differences of chromosome 22q11.2 duplication structure predispose differentially to microdeletion and inversion - Nature Communications
The authors resolve 63 structurally diverse haplotype structures for the 22q11.2 deletion syndrome region. Deletion risk differs depending on structure; individuals of African ancestry are enriched fo...
https://www.nature.com/articles/s41467-026-71905-y
3 days ago
0
0
0
In the quiet life of a cell, a broken DNA strand was once thought to be the end of the story. But often, that break is just a door left open, where RNA stays as a gentle echo.
www.nature.com/articles/s41...
loading . . .
DNA lesions can frequently precede DNA:RNA hybrid accumulation - Nature Communications
DNA:RNA hybrids are linked to genetic instability in several pathological situations. Here, the authors report that various types of DNA lesions can trigger hybrid formation in yeast and humans, calli...
https://www.nature.com/articles/s41467-025-57588-x
4 days ago
0
0
0
A New Map for Survival In broken cells, a restless protein sweeps away the repair team before they can heal the DNA and restore calm. Removing this overactive cleaner lets a hidden backup crew mend the damage, showing that life always finds a way to persist.
www.science.org/doi/10.1126/...
loading . . .
FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments
Homologous recombination (HR) deficiency upon Breast Cancer Gene 2 (BRCA2) loss arises from defects in the formation of RAD51 nucleoprotein filaments. We demonstrate that loss of the anti-recombinase ...
https://www.science.org/doi/10.1126/science.adt1210
4 days ago
0
0
0
š¼The Healing Rhythm Fragile DNA whispers its wounds through mechanical twists that guide the cellās tiny sculptors. These molecular artists gently reshape the crowded coils to mend every broken thread with quiet grace.
www.mdpi.com/2218-273X/15...
loading . . .
https://www.mdpi.com/2218-273X/15/5/649
5 days ago
0
0
0
A Gentle Pull Toward Home Three matching letters act like a secret handshake, pulling broken DNA into a close, healing embrace. This natural grace allows the cell to mend its wounds and keep the story of life flowing.
www.nature.com/articles/s41...
loading . . .
DNA end configurations dictate synaptic complex formation during NHEJ-mediated end bridging - Nature Communications
DNA double-strand breaks are primarily repaired by non-homologous end joining, which requires synapsis of broken DNA ends. Here, the authors show that DNA end configurations, particularly short microh...
https://www.nature.com/articles/s41467-026-68417-0
6 days ago
0
0
0
The Price of Openness Space radiation triggers a 75% increase in genetic misrepair within the relaxed, open regions of our DNA. The very architecture that allows genes to breathe also makes them fragile targets under the cosmic stars.
pubmed.ncbi.nlm.nih.gov/42331460/
loading . . .
DNA decompaction enhances the formation of radiation-induced DNA double strand breaks and chromosome aberrations - PubMed
Chromosome aberrations, a biomarker of space radiation-induced carcinogenesis, are a direct consequence of DNA double-strand break (DSB) misrepair and play an important role in the fate of irradiated ...
https://pubmed.ncbi.nlm.nih.gov/42331460/
6 days ago
0
0
0
The Internal Mechanic Cancer cells stay strong by using TTI1 to mend their DNA during the storm of treatment. Breaking this hidden repair cycle turns resistance into a new beginning for healing.
pmc.ncbi.nlm.nih.gov/articles/PMC...
loading . . .
TELO2-interacting protein 1 (TTI1), a novel Wnt/β-catenin target gene, decreases chemo-sensitivity in colorectal cancer by modulating DNA damage responses
Colorectal cancer is frequently driven by hyperactivation of Wnt/β-catenin signaling, which also contributes to reduced responsiveness to chemotherapy. However, how aberrant Wnt/β-catenin signaling en...
https://pmc.ncbi.nlm.nih.gov/articles/PMC13263369/
9 days ago
0
0
0
Ripples in the Genetic Stream A sudden surge of thyroid hormone T3 stirs a brief storm of DNA stress, activating the cellās internal repair lights. Within two days, this transient pulse fades as the cell restores its balance and mends the fragile strands of life.
www.mdpi.com/1422-0067/27...
loading . . .
https://www.mdpi.com/1422-0067/27/2/668
9 days ago
0
0
0
A Hunterās New Path Trapped lactate guides a cellular sensor inward to stop cancer from healing itself. This gentle shift within the cell leaves the enemy fragile, letting therapy finally bring the light of hope.
www.cell.com/cell-reports...
loading . . .
Lactylation-driven nuclear RIG-I promoted by lactate transporter inhibitor suppresses DNA damage repair through inhibiting PARP1 activity
Li et al. demonstrate that lactylation drives the nuclear function of RIG-I to suppress DNA damage repair by inhibiting PARP activity. This finding provides a rational basis for the potential co-admin...
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01626-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124725016262%3Fshowall%3Dtrue
9 days ago
0
0
0
The Healing Bond Inside brain cancer, MEOX2 and PARP1 work together to heal the tumorās DNA and survive treatment. Removing this support makes the cells fragile, opening a new door to finally defeat the disease.
www.sciencedirect.com/science/arti...
loading . . .
MEOX2 enhances DNA repair and therapy resistance in Glioblastoma stem-like cells via PARP1 interaction
The most widely accepted hypothesis for glioblastoma development posits that glioblastoma stem-like cells (GSCs) play a central role in tumor initiatiā¦
https://www.sciencedirect.com/science/article/pii/S0304383526000479?via%3Dihub
9 days ago
0
0
0
A Sweet Armor for Survival A tiny sugar molecule protects the XRCC4 protein, helping cancer cells stitch their broken DNA back together. Stripping away this sweetness stops the healing process and leaves the tumor vulnerable to the medicine meant to stop it.
www.nature.com/articles/s41...
loading . . .
O-GlcNAcylation of XRCC4 controls its stability and confers resistance to DNA double-strand break damage in cancer cells - Cell Death & Disease
Cell Death & Disease - O-GlcNAcylation of XRCC4 controls its stability and confers resistance to DNA double-strand break damage in cancer cells
https://www.nature.com/articles/s41419-025-08209-4
9 days ago
0
0
0
A Beautiful Undoing A hidden tangle in the DNA makes a strong cancer cell surprisingly fragile. This new medicine turns that chaos into a soft rain that heals the body.
pmc.ncbi.nlm.nih.gov/articles/PMC...
loading . . .
Checking your browser - reCAPTCHA
https://pmc.ncbi.nlm.nih.gov/articles/PMC12904052/
10 days ago
0
0
0
The DNA's Gentle Menders RPA2 and POLI genes act as delicate healers, fixing tiny breaks in the genetic code. Higher activity in these molecular helpers lowers the risk of prostate cancer, offering a vital path toward future health.
pmc.ncbi.nlm.nih.gov/articles/PMC...
loading . . .
Association of DNA damage repair related genes with prostate cancer: A multi-omics Mendelian Randomization analysis
The relationship between prostate cancer and DNA damage repair remains incompletely elucidated. This study employs Mendelian Randomization to explore the causal relationships between DNA Damage Repair...
https://pmc.ncbi.nlm.nih.gov/articles/PMC13225592/
10 days ago
0
0
0
š” A New Light for Healing The SMC4 gene helps cancer cells repair themselves and stay hidden, but removing it lets the bodyās natural strength and treatment work together.
link.springer.com/article/10.1...
loading . . .
SMC4/SMAD3/NF-ĪŗB axis drives cervical cancer progression and radioresistance via DNA damage repair and immune modulation - Journal of Translational Medicine
Objective Cervical cancer remains a significant global health burden, with the molecular determinants of its progression and therapeutic resistance not fully elucidated. This study aimed to identify D...
https://link.springer.com/article/10.1186/s12967-026-07979-5
13 days ago
0
0
0
A Secret Shield for Survival Breast cancer cells use the P4HA2 gene to repair themselves and survive radiation. Removing this hidden defense lets treatment finally reach its mark, opening a new and powerful path for healing.
www.thno.org/v16p2192.htm
loading . . .
Single-cell and spatial transcriptomics reveal P4HA2-mediated radiotherapy resistance mechanisms in breast cancer
Single-cell and spatial transcriptomics reveal P4HA2-mediated radiotherapy resistance mechanisms in breast cancer
https://www.thno.org/v16p2192.htm
13 days ago
0
0
0
Cancer hides its wounds by erasing the molecular alarms that should call the immune system to action. Targeting a key protein restores these signals, finally allowing the bodyās defenses to see and destroy the tumor.
www.cell.com/cancer-cell/...
loading . . .
Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated immune response to DNA damage
Li et al. show that SPOP mutations and USP7 overexpression promote TREX1 upregulation, leading to increased cytosolic DNA degradation and suppression of cGAS-STING-mediated immune activation. Targetin...
https://www.cell.com/cancer-cell/fulltext/S1535-6108(25)00547-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1535610825005471%3Fshowall%3Dtrue
15 days ago
0
1
0
Mending Lifeās Pulse A protein named MAEA mends broken DNA threads, keeping the cellular script flowing as smoothly as morning rain. If this guide falters, the rhythm of growth stalls, leading to a developmental condition known as DIADEM.
link.springer.com/article/10.1...
loading . . .
Loss of CTLH component MAEA impairs DNA repair and replication and leads to developmental delay - EMBO Molecular Medicine
Ubiquitin E3 ligases play crucial roles in the DNA damage response (DDR) by modulating the turnover, localization, activation, and interactions of DDR and DNA replication proteins. We performed a CRIS...
https://link.springer.com/article/10.1038/s44321-025-00352-x
15 days ago
0
0
0
š¬š§ A beautiful rainy evening at the University of Grenoble Alpes. š«š· Une magnifique soirĆ©e pluvieuse Ć l'UniversitĆ© Grenoble Alpes.
16 days ago
0
0
0
Cancerās Secret Weakness Cancer cells use hidden repair paths to mend their breaks and keep growing. New treatments turn these survival tools into a way to finally stop the disease.
pubmed.ncbi.nlm.nih.gov/41716447/
loading . . .
Manipulating DNA repair and the DNA damage response to improve cancer therapy - PubMed
Manipulating DNA repair and the DNA damage response to improve cancer therapy
https://pubmed.ncbi.nlm.nih.gov/41716447/
19 days ago
0
0
0
The Hidden Architect LncRNA-EME1 binds to BRCA1, helping cervical cancer cells repair DNA and survive the storm of radiation. Stopping this secret molecule breaks the repair shield, allowing the light of treatment to finally reach its mark and heal.
pmc.ncbi.nlm.nih.gov/articles/PMC...
loading . . .
LncRNA-EME1 enhances BRCA1 recruitment and alters repair of DNA damage in cervical cancer radioresistance
Cervical cancer is a significant cause of mortality in women globally, and radioresistance limits the effectiveness of standard radiotherapy treatment. Exploring the molecular mechanisms that contribu...
https://pmc.ncbi.nlm.nih.gov/articles/PMC12528910/
20 days ago
0
0
0
The Whispering Circles of Life Tiny DNA loops show a cell has successfully healed its inner wounds. These small circles give life the quiet strength to swim toward the promise of a new day.
link.springer.com/article/10.1...
loading . . .
Reduced eccDNA content in idiopathic asthenozoospermia sperm is associated with compromised DNA repair capacity and elevated DNA damage - Cellular & Molecular Biology Letters
Background Despite representing approximately 30% of male infertility cases, idiopathic asthenozoospermia (iAZS) remains etiologically uncharacterized. Extrachromosomal circular DNA (eccDNA) is mobile...
https://link.springer.com/article/10.1186/s11658-026-00857-4
21 days ago
0
0
0
The Hidden Roadblock In busy cells, natural RNA tangles act as barriers that stop CRISPR from fixing genes with high precision. Gently clearing these molecular knots restores the repair, allowing modern medicine to work in perfect harmony with the rhythm of life.
www.cell.com/molecular-th...
loading . . .
Potential effects of endogenous RNA/DNA hybrids on CRISPR-Cas9-mediated homology-directed repair
Kay and colleagues discovered how R-loops can modulate Cas9-mediated genome editing by suppressing homology-directed repair (HDR) at R-loop-rich regions in proliferating cells. Reducing R-loops levels...
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(26)00051-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS216225312600051X%3Fshowall%3Dtrue
21 days ago
0
1
0
A Bridge for the Soul The Huntingtin protein acts as a gentle scaffold, mending broken DNA to keep the brain's cells healthy and whole. When this connection fails, the cell loses its light, uncovering a new secret to how the mind heals itself.
www.life-science-alliance.org/content/9/6/...
loading . . .
Huntingtin (HTT) interactome in regulation of DNA repair/remodeling and RNA processing pathways
Huntingtonās disease (HD), an uncurable neurodegenerative disorder, is caused by CAG repeat expansion in the HD gene encoding mutant huntingtin protein. DNA damage response is implicated in HD pathoge...
https://www.life-science-alliance.org/content/9/6/e202503424
21 days ago
0
0
0
The Echo of Restoration When lifeās thread breaks, a soft ripple tells the engines of the cell to gracefully fade into the mist. This gentle stillness allows all energy to flow toward healing, keeping the song of existence in perfect harmony.
pmc.ncbi.nlm.nih.gov/articles/PMC...
loading . . .
RNA polymerase II degradation triggered by DNA repair occurs in trans and independently of how the lesion is recognized
In response to DNA damage, RPB1, the catalytic subunit of RNA Polymerase II (RNAPII), is degraded by the ubiquitināproteasome system. Degradation models only consider transcriptionally engaged molecul...
https://pmc.ncbi.nlm.nih.gov/articles/PMC12781871/
24 days ago
0
0
0
ā“ļøThe Bloom of a Break To grow hundreds of tiny hairs, a cell must first break its own DNA. These intentional cracks serve as a signal, turning damage into the very foundation of new life.
www.cell.com/current-biol...
loading . . .
The DNA damage response pathway is required for multiciliated cell differentiation
Jewett et al. find that multiciliated cells exhibit abundant DNA damage during differentiation and require the DNA damage response kinases. These results reveal how DNA damage signaling can be used to...
https://www.cell.com/current-biology/fulltext/S0960-9822(26)00316-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0960982226003167%3Fshowall%3Dtrue
25 days ago
0
0
0
š¼The Skinās Song Pausing one small molecule lets cells rebuild the proteins that heal DNA damage. This soft change in rhythm stops tumors from growing and reveals a new path to health.
onlinelibrary.wiley.com/doi/abs/10.1...
loading . . .
Targeting the m6A RNA demethylase FTO enhances UVBāinduced DNA damage repair and suppresses skin tumor growth
FTO inhibition enhances UVB-induced CPD repair in human keratinocytes by increasing m6A-modification of the GGR factor DDB2 in a METTL14-dependent manner, increasing DDB2 protein translation. Schemat...
https://onlinelibrary.wiley.com/doi/abs/10.1111/php.70060
26 days ago
0
0
0
The Bridge to a Healthy Cell TOPBP1 and PLK1 unite during division to mend broken DNA, ensuring lifeās code passes safely to the next generation.
academic.oup.com/nar/article/...
loading . . .
TOPBP1āPLK1 interaction preserves genome integrity during mitosis
Abstract. TOPBP1 is a scaffold protein with multiple functions in genome integrity. During mitosis, TOPBP1 is coordinating DNA repair and genome maintenanc
https://academic.oup.com/nar/article/54/9/gkag462/8675580?login=false
27 days ago
0
0
0
A common remedy for the soul ignites a new fire. This pill starves cancer of its secret fuel, triggering a fiery death that finally shows the body exactly where to fight.
www.cell.com/cell-reports...
loading . . .
5-HT reuptake blockade induces pyroptosis in BRAFV600E-mutated melanomas via remodeling histone serotonylation
Li et al. demonstrate that paroxetine hydrochloride, an FDA-approved antidepressant, induces pyroptosis in melanoma and drives anti-tumor immunity. This occurs as 5-HT reuptake inhibition reduces H3Q5...
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00610-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS266637912500610X%3Fshowall%3Dtrue#
29 days ago
0
0
0
The Hidden Symphony of Genetic Healing Thousands of gene pairs map the invisible paths that repair life's blueprint, revealing the secret bonds that sustain cellular survival.
www.cell.com/cell-reports...
loading . . .
Uncovering genetic interactions in the DNA repair network in response to endogenous damage and ionizing radiation
Nebenfuehr et al. perform a combinatorial CRISPR-Cas9 screen targeting 461 DNA damage response genes under basal and irradiated conditions. The study maps thousands of genetic interactions, generating...
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01622-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124725016225%3Fshowall%3Dtrue
29 days ago
0
0
0
The Beauty of Imperfect Repair Pol Īø mends broken DNA by accepting flawed matches, saving the cell while leaving the unique genetic scars that reveal the origins of cancer.
onlinelibrary.wiley.com/doi/10.1002/...
loading . . .
Beyond Short Microhomologies: MismatchāCompatible Pol ĪøāMediated DNA Damage Repair
Pol Īø is traditionally thought to use a short, perfectly matched microhomology (MH) to initiate end-joining repair of a DNA double-strand break. Emerging evidence indicates that Pol Īø generally utili....
https://onlinelibrary.wiley.com/doi/10.1002/bies.70129
29 days ago
0
0
0
A Refreshing Touch for DNA Like a gentle mist, the molecule SAM reaches the DNA and softens the sunās impact in just two minutes. It prevents light-induced scars at the very start, keeping the internal landscape clear and resilient.
www.mdpi.com/2073-4425/17...
loading . . .
https://www.mdpi.com/2073-4425/17/4/487
29 days ago
0
0
0
The Master Trap Ovarian cancer falls when a multi-dimensional strategy targets metabolism and genetic codes together, leaving no path for the disease to survive.
link.springer.com/article/10.1...
loading . . .
Exploiting synthetic lethality in epithelial ovarian cancer: multi-dimensional approaches beyond DNA damage repair - Molecular Cancer
Synthetic lethality (SL) is a therapeutic approach that selectively target cancer cells via the disruption of two interdependent molecular targets, which together become essential in the cancer contex...
https://link.springer.com/article/10.1186/s12943-025-02562-w
29 days ago
0
0
0
š§¬Healing the Genetic Code A stroke breaks the fragile strands of the brain's blueprint, leaving the manual of life in pieces. Boosting tiny cellular weavers to stitch this code back together brings a gentle rain of hope for recovery.
pmc.ncbi.nlm.nih.gov/articles/PMC...
loading . . .
Checking your browser - reCAPTCHA
https://pmc.ncbi.nlm.nih.gov/articles/PMC12769742/
29 days ago
0
0
0
The Pulse's Story Every beat sends ripples through the heartās DNA, leaving tiny hidden tears in the blueprint of life. Soothing the cell's overactive repair signals protects the rhythm and restores the heart's natural strength.
journals.physiology.org/doi/full/10....
loading . . .
DNA damage and repair in cardiomyopathy: mechanisms and therapeutic opportunities | American Journal of Physiology-Heart and Circulatory Physiology | American Physiological Society
Accumulating evidence from human clinical cohorts and animal models indicates that DNA damage plays a pivotal role in the initiation, progression, and severity of cardiomyopathy subtypes. Cardiomyocyt...
https://journals.physiology.org/doi/full/10.1152/ajpheart.00774.2025?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org
about 1 month ago
1
0
0
The Heartās Architect CHD4 crafts the pulse of life, though rare genetic shifts can disrupt this delicate design. Mapping these specific errors brings clarity to rare diseases, offering a gentle path toward personalized healing.
onlinelibrary.wiley.com/doi/10.1155/...
loading . . .
In silico Analysis of CHD4 Mutations Reveals DomaināSpecific Impacts on Cardiovascular Disorders Among Patients With Rare Diseases
Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a critical ATP-dependent chromatin remodeler that plays fundamental roles in transcriptional repression, DNA damage repair, and lineage specifica....
https://onlinelibrary.wiley.com/doi/10.1155/humu/3575977
about 1 month ago
0
0
0
A Hidden Release A quiet anchor holds the alarm until a virus sets the cellās defense free.
journals.asm.org/doi/10.1128/...
loading . . .
Linker histone H1.2 inhibits HSV-1-induced IFN response via cGAS | mBio
Previous studies on histone H1.2 mainly focused on its function of DNA damage repair and chromatin stability. However, our research found the new function and mechanism of H1.2 in anti-infection immun...
https://journals.asm.org/doi/10.1128/mbio.03881-25?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
about 1 month ago
0
0
0
A Vibrant Heartbeat Within H2A.Z brings a soft fluidity to the proteins cradling our genetic code. This delicate dance loosens the grip on DNA, letting life read and repair itself with grace.
www.mcponline.org/article/S153...
loading . . .
Histone Variant H2A.Z Enhances Histone and Nucleosome Dynamics
In BriefThe sequence and structure of the histone H2A-H2B heterodimer are highly conserved among eukaryotic homologs, such as frogs and humans, as well as functionally distinct variants, such as H2A.Z...
https://www.mcponline.org/article/S1535-9476(26)00013-7/fulltext
about 1 month ago
0
0
0
The Fragile Trap Tiny chimeric molecules weave irreversible knots between DNA and proteins, turning the cell's library into a landscape of toxic tangles.
pubs.acs.org/doi/10.1021/...
loading . . .
DNAāProtein Cross-Link Formation and Cellular Toxicity by Chimeric Bis-Electrophiles
DNAāprotein cross-links (DPCs) and DNAāDNA interstrand cross-links (ICLs) strongly block genetic expression. Chemical agents that preferentially produce one of these DNA damage types over the other are potentially useful cellular probes and pharmacological agents but are uncommon. A chimeric alkylating agent (MEBAC) selectively forms DPCs over ICLs by reacting with the ε-amine of lysine. Here we determine that the majority of DPCs formed by MEBAC in NCPs are between dG and lysines in the histone amino terminal tails. We also compare the reactivity of MEBAC and an isomer (m-MEBAC). Model studies indicate that m-MEBAC reacts ā¼50% more rapidly than MEBAC with a primary amine. DPC yields in nucleosome core particles (NCPs) from MEBAC and m-MEBAC are approximately equal at all but the highest concentration tested. Comparisons between the reactivity of MEBAC and a nitrogen mustard with NCPs and nuclear lysates illustrate the advantage of the former for generating DPCs. m-MEBAC and MEBAC cytotoxicity in human cells are comparable and are enhanced when proteasomal DPC repair is inhibited. These experiments validate the utility of this family of chimeric bis-electrophiles as chemical tools for forming DPCs in the test tube and in cells.
https://pubs.acs.org/doi/10.1021/acs.joc.5c03246
about 1 month ago
0
0
0
The Breath of Generations ZCWPW2 acts as a gentle guide, shielding DNA repair proteins with a soft embrace of lactate. This vital protein protects the spark of life, ensuring the dance of heredity never stops.
academic.oup.com/nar/article/...
loading . . .
A novel dual histone mark reader ZCWPW2 regulates meiotic recombination through lactylation and transcriptional regulation in humans and mice
Abstract. Meiotic recombination ensures accurate chromosome segregation and genetic diversity during gametogenesis, and its disruption leads to infertility
https://academic.oup.com/nar/article/54/3/gkag049/8439240?login=false
about 1 month ago
0
2
0
The Skinās Hidden Script Inherited mutations in DNA repair pathways double the risk of radiation sensitivity, guiding doctors toward a truly personal path to recovery.
pubmed.ncbi.nlm.nih.gov/41897566/
loading . . .
Functional Germline DNA Repair Mutations as Predictors of Acute Radiodermatitis in Breast Cancer - PubMed
<span><b>Background/Objectives</b>: Acute radiotherapy-induced skin toxicity is a common complication in breast cancer treatment, with marked interindividual variability not fully explained by clinica...
https://pubmed.ncbi.nlm.nih.gov/41897566/
about 1 month ago
0
1
0
The Architectās Flaw Blocking a cell's fat enzyme destroys the internal mechanic that repairs broken DNA. This shift makes cancer fragile, allowing treatment to clear the path and stop the disease from returning.
pmc.ncbi.nlm.nih.gov/articles/PMC...
loading . . .
FASN Inhibition Enhances the Efficacy of Chemotherapy in Colorectal Cancer by Inhibiting the DNA Damage Response
Altered lipid metabolism is a potential targetable metabolic vulnerability in colorectal cancer (CRC). Fatty acid synthase (FASN), the rate limiting enzyme of de novo lipogenesis, is an important regu...
https://pmc.ncbi.nlm.nih.gov/articles/PMC13007557/
about 1 month ago
2
0
0
Beating Cancer's Shield HNSCC uses ANGPTL4 to repair DNA and survive chemotherapy. Blocking this protein breaks drug resistance and makes the treatment effective again.
www.pnas.org/doi/10.1073/...
loading . . .
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
https://www.pnas.org/doi/10.1073/pnas.2510265123?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
about 1 month ago
0
0
0
āThe Tumor's Fatal Trade-off A repair protein abandons its post to fuel growth, leaving the cancerās DNA fragile and exposed. This internal neglect creates a perfect opening for targeted drugs to strike, turning the tumorās strategy against it.
aacrjournals.org/cancerres/ar...
loading . . .
Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP Inhibition
Association between ER and MDC1 in lobular breast cancer cells induces a form of dysfunctional homologous recombination, distinct from āBRCAness,ā that creates the mechanistic context for synthetic le...
https://aacrjournals.org/cancerres/article-abstract/86/7/1605/775636/Altered-MDC1-Interactions-and-Dysfunctional-DNA?redirectedFrom=fulltext
about 1 month ago
0
0
0
šThe Sunās Quick Genetic Pen Sunlight creates fragile knots in DNA where chemical shifts at TCG spots spark skin cancer mutations with incredible speed. As DNA wraps tightly or moves with grace, the environment writes a permanent story into the very core of life.
genome.cshlp.org/content/earl...
loading . . .
Genome-wide maps of CPD deamination in yeast reveal the impact of DNA sequence context and nucleosome architecture on cytosine deamination rates
UV light induces cyclobutane pyrimidine dimers (CPDs) and other mutagenic lesions in cellular DNA. Cytosine-containing CPDs can subsequently undergo rapid deamination to uracil, a process that has been linked to UV mutagenesis. However, the impact of genomic context and chromatin architecture on CPD deamination rates in cells remains poorly understood. Here, we develop a method known as dCPD-seq to map deaminated CPDs (dCPDs) across the genome of repair-deficient yeast cells at single-nucleotide resolution. Our dCPD-seq data reveal that sequence context significantly modulates CPD deamination rates in UV-irradiated yeast cells, with CPDs in TCG contexts showing particularly rapid deamination rates. Our analysis indicates that rapid CPD deamination can explain why UV-induced mutations are specifically enriched at TCG sequences, both in UV-irradiated yeast cells and in human skin cancers. CPD deamination is suppressed near the transcription start and end sites of yeast genes, which may in part by mediated by DNA-bound transcription factors. Finally, we show that the wrapping of DNA in nucleosomes modulates CPD deamination in yeast cells. Our data indicate that CPD deamination is elevated at minor-in rotational positions where the DNA minor groove faces the histone octamer, likely owing to increased solvent accessibility of the C4 position of the cytosine base. Moreover, we also observe strand-specific enrichment of CPD deamination at rotational positions where the DNA backbone faces out toward the solvent. Taken together, these findings reveal how DNA sequence context and chromatin architecture modulates CPD deamination rates across a eukaryotic genome.
https://genome.cshlp.org/content/early/2025/12/09/gr280384124
about 2 months ago
0
0
0
š¦The Butterflyās Hidden Struggle The thyroidās vital energy production triggers internal storms that crack its genetic blueprint every single day. Molecular healers must stitch these broken threads to prevent disease and guide the body back to balance.
academic.oup.com/edrv/article...
loading . . .
DNA Damage and Repair in Thyroid Physiology and Disease
Abstract. The thyroid is exposed to DNA damage induced by normal physiological processes (eg, oxidative stress resulting from thyroid hormone synthesis or
https://academic.oup.com/edrv/article/47/1/121/8251749?login=false
about 2 months ago
0
0
0
A Precise Strike Aurkine16 breaks cancerās code in three spots at once to stop the disease forever. It flows softly past healthy cells, opening a kind and safe door for a future full of hope.
pubs.acs.org/doi/10.1021/...
loading . . .
Computational Analysis of a Next-Generation Platinum-Based Chemotherapies that Induce DNA Double-Strand Breaks
Platinum-based chemotherapeutic agents, such as cisplatin (Cis-Pt(II)), are widely used in cancer treatment but are limited by toxicity, DNA repair by cancer cells, and drug resistance. To address the...
https://pubs.acs.org/doi/10.1021/acs.jcim.5c01654
about 2 months ago
0
0
0
š¬The Smoke's Path Molecules strike the open DNA bridges and outward-facing spirals where the genetic code is most exposed. These physical vulnerabilities carve the unique map of lung cancer, deciding exactly where the damage remains.
www.jbc.org/article/S002...
loading . . .
Altered benzo[a]pyrene adduct formation in nucleosomes establishes distinct mutational patterns in lung cancer
Benzo[a]pyrene is a carcinogen in tobacco smoke that, when metabolized to benzo[a]pyrene diol epoxide (BPDE), induces mutagenic DNA lesions that promote the development of lung cancer. In lung cells, ...
https://www.jbc.org/article/S0021-9258(26)00161-4/fulltext
about 2 months ago
0
0
0
Load more
feeds!
log in