I am delighted to share that my work in the @aaronwhiteley.bsky.social lab is now on bioRxiv! We used a large-scale genetic screen to begin defining the vast landscape of phage proteins that trigger immune signaling in bacteria. www.biorxiv.org/content/10.1...

Words cannot describe how excited I am to share the findings from the second half of my postdoc in @aaronwhiteley.bsky.social's lab where we discover that bacteria use functional amyloids to defend themselves from predatory bacteria. rdcu.be/euu5Y. See thread for details on this epic adventure 1/.

I am delighted to announce that this past spring, I graduated from the University of Colorado Boulder PhD program. My dissertation work was titled "Defense against predatory bacteria" (1/3)

Check out our new story led by @aesully98.bsky.social describing how bacteria turn immune evasion against phage! In collaboration with @benmorehouse.bsky.social lab, we discover that bacteria guard their nucleotide second messenger pool using a nucleotidyltransferase related to Cas10/CRISPR enzymes

Preprint alert! ✨ In this project that I co-led with @benadler.bsky.social, we show that a miniature CRISPR-Cas10-like enzyme, mCpol, uses a novel inverse signaling mechanism to prevent the spread of viruses that attempt immune evasion by depleting host cyclic nucleotides. Check it out:

Excited to share that my work from the @aaronwhiteley.bsky.social lab is now on bioRxiv! With @benmorehouse.bsky.social, we discovered that the Panoptes defense system—named after the all-seeing watchman of Hera—uses decoy nucleotides to detect phage anti-defense proteins.

It’s here! Thrilled to be sharing a review article I wrote with @aaronwhiteley.bsky.social exploring the similarities and conservation of immune systems across life rdcu.be/dzSa3

Our review comparing bacterial and eukaryotic immune systems is out now. Check out Hannah’s thread for the highlights! www.nature.com/articles/s41...

Hi everyone! A quick intro about me in this new virtual space! My name is Ryan Sayegh (pronounced sigh-egg). I use he/they pronouns, and I'm a third-year Ph.D. candidate in the @aaronwhiteley.bsky.social lab interested in host-pathogen interactions in microbes. @ryansayegh98 on the other blue app.