poliispeed.bsky.social (@poliispeed.bsky.social)

Happy to share that David and I have a new review out in @annualreviews.bsky.social of Biochemistry! We break down Pol II pausing, its evidence in vitro/in vivo, and its two key fates which are in kinetic competition: pause release vs premature termination. www.annualreviews.org/content/jour...

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The Promoter-Proximal Pause: A Decision Point Governing RNA Polymerase II Fate A signature feature of transcription on most genes in multicellular animals is that RNA polymerase II (RNAPII) piles up approximately 50 bases downstream of the start site at the promoter-proximal pau... https://www.annualreviews.org/content/journals/10.1146/annurev-biochem-051424-053703