By engineering MyoAAV, we suppressed cardiac toxicity of transgenes and achieved skeletal muscle–specific systemic delivery. Using this platform, we successfully induced fast myofiber remodeling and muscle hypertrophy via a large Maf transcription factor. doi.org/10.64898/202...

By engineering MyoAAV, we suppressed cardiac toxicity of transgenes and achieved skeletal muscle–specific systemic delivery. Using this platform, we successfully induced fast myofiber remodeling and muscle hypertrophy via a large Maf transcription factor. doi.org/10.64898/202...

結構いい感じのデータがでてきて順調にいきそうだ！

0.33g mitigates muscle atrophy while 0.67g preserves muscle function and myofiber type composition in mice during spaceflight | Science Advances www.science.org/doi/10.1126/...

New bioRxiv preprint from Pascal Maire’s group is out! I’m happy to have made a small contribution and to be included as a co-author. “c-MAF transduces motor neuron firing to sustain fast-glycolytic myofibers and neuromuscular junctions” www.biorxiv.org/content/10.6... #myoblue

Our mini-review on large Maf transcription factors—the principal regulators of fast-twitch myofibers that we identified—has just been published. www.jstage.jst.go.jp/article/trs/...

Excited to share our new paper in Skeletal Muscle! We show that large Maf transcription factors can robustly induce MYH4, normally silent in humans. In human muscle, Mafa and Maf expression correlate with fast fiber content. #myoblue rdcu.be/ex0un

Our new review, “The Multifaceted Role of MyoD in Adult Skeletal Muscle: Homeostasis, Regeneration, and Diseases,” is now available online in AJP Cell Physiol. journals.physiology.org/doi/abs/10.1... @myoblue.bsky.social

Myogenesis gone awry: the role of developmental pathways in rhabdomyosarcoma www.frontiersin.org/journals/cel...

Building upon our previous study published in Cell Rep (10.1016/j.celrep.2023.112289), which identified large Mafs as essential regulators of type IIb myofiber specification in mice, this work extends our understanding to humans. biorxiv.org/cgi/content/... #Myotwitter