Most important piece I've read on AI this year. x.com/WillManidis/...

Palisades Fire Exactly one year ago, on this spot, a fire broke out that destroyed our city. The surrounds and community look very different today. These massive disasters will continue until these specific factors are addressed and mitigated. Reasons for the disaster below (a partial list):

What’s the next number in this sequence (just handed to me by my 6yo son). Simple but stumped me and GPT.

Today, I gave an informal seminar to students and faculty on the accelerating impact new AI models like o3 will have on research and how to navigate those changes. Check it out👇 Resistance is Futile: AGI-Augmented Research and the New Scientific Method youtu.be/x6gv68fHw7Q?... via @YouTube

Best view at USC.

It's been 3.5 months since this experiment on scientific reasoning. The improvements in SOTA models since are remarkable. Here's OpenAI's o3 model's first attempt at reviewing my 2017 R01-A1 submission. Would you do a better job?

If you don't realize that AGI is already here, you must be too lazy or incurious to try o3.

Testing out DeepSeek-R1's ability to do "science" in one-shot. I asked it to critique my 2017 R01 proposal (Impact 26, 10%, funded by NINDS. I wrote the proposal, have rights to share it. It's first-shot response is indistinguishable from a median quality reviewer's. What do we do now?

If anyone wants to follow along, I have a bunch of media posts on X. Sorry no time to duplicate. Pacific Palisades is mostly destroyed. Half my friends have lost their homes. Mine not gone yet but not looking good.

How my day is going #PalisadesFire

Good morning 2025! Thank you LAFD!

Bringing my cooking talents to Bluesky

New surf break

I’ll tend to keep crypto posts off here, but there is an intriguing niche of the space that’s exploded in last 4 weeks. Jailbroken AI agents are augmenting training, tweeting bangers, and even dropping 🔥 mixtapes, all funded by their own memecoins people are bidding. Leaders are Zerebro and Goat.

One cultural rift I've observed in neuroscience: Connectomics folks tend to be firm in their belief that only a dense connectome is useful, sparse reconstructions need not apply. Meanwhile physiologists are content to randomly sample a few neurons here and there...

Proof of life and hood tour with the USC prof crew, Mahdi and Lars.

Hi all, This below account with two ‘s’ is an imposter, please report and don’t interact with DMs from it. Stay safe! 🙏 bsky.app/profile/andr...

This paper is incredible. EM level connectomics on a light microscope. www.biorxiv.org/content/10.1...

Who’s heading to Austin for CZI? 🙋‍♂️

Blast from the past: The Investigator : UCSD Neuromovie 2005 youtu.be/-Yf7wA6TAHY?... Could use an editor tbh…

There are rules! I only found this out quite recently! “The rule is that multiple adjectives are always ranked accordingly: opinion, size, age, shape, colour, origin, material, purpose.” www.theguardian.com/commentisfre...

Good morning

New desert house mix from the USC Neuroscience Graduate Program retreat last weekend. www.mixcloud.com/sahires/usc-...

Quick math test: 230 - 220 x 0.5 = ? You probably won't believe it, but the answer is 5!

Not bad. Reducing bike course by 45% certainly hurt placing. Fastest AG bike split. Better than expected run. If I can fix my horrible ocean swim and take transitions seriously, maybe can podium in the 45-49 AG next year.

LFG

Anyone in dance music in Boston 1995-05 felt Shalako’s influence. Satellite Records, Redlight raves, techno and jungle weeklies at the Phoenix Landing. All his work. His sunset set from our summer party is playing 9pm PDT tonight on 99.1 in LA & online www.klbp.org

Results of the #legmullet experiment. TLDR: full shave with ankle socks beats all variations. strava.app.link/5nOsXgoutDb

Preparing a landmark study of practical aerodynamics. Results tomorrow.

Cannot believe we approved molnupiravir, when it was obvious it would increase SARS-Cov-2 genetic diversity and potentially transmission fitness when considered at a global population level. Corrupt policymaking. www.nature.com/articles/s41...

Tire swap from gravel Pathfinder Pro 32s to aero and rolling resistance optimized Continental GP5000 S TR 30s complete. Ready to race, if the race is ready.

Max giving me some math questions. He invented two math symbols. Guess what they mean.

Trust, but verify. Show my your Strava.

Wow. Computer graphics have really progressed since Nethack 3.6.7 was released in February.

It’s nearly the one year anniversary of the QQL generative art project by Tyler Hobbes and Dandelion Wist You can generate infinite art via algorithm at qql.art but to add to the official collection requires a mint pass. Very cool. Check the vibe in this video. vimeo.com/867362731

Explaining bits and bytes to Maxwell. Growing up with a 2400 baud modem, I’m amazed we invented systems that can stream 360,000,000 bits of information per second from a distant machine to mine via invisible electromagnetic radiation. And do it in parallel to millions of machines in the world.

Malibu Triathlon, one of the best in the country, might be cancelled because last winters rain flooded a PCH underpass by Zuma beach and a fish experiencing homelessness has taken up residence in the underpass.

Mulholland Ride. Full Mulholland Drive and Highway loop with Mark Chaisson. Amazed William Mulholland built this, Barbara Fine preserved the middle as a dirt road, and thankful we can ride this epic 55-mile road across the Santa Monica mountains. strava.app.link/vUkP2cn2aDb

Do not drill the glass.

Which square is the least likely for a king to be on in chess? -Max, age 5 Anyone run the numbers on this before?

This is the geographic center of Los Angeles.

Obsessed with this idea…

After squandering my early bsky presence due to inability to wean myself from 14 years of pseudo-clout inertia, I've ported my following list. Fuck it we ball.

The PE stands for Placebo Effect. www.dailymail.co.uk/health/artic...

Current status: Live-streaming 200ft lava fountains. www.youtube.com/live/tBh-ZhI...

Real time cracking of RSA 2048 encryption via GPU accelerated complex number differential equations. Big if true! www.memcpu.com/tem_08_31_23/

Namaste 🙏

The baker invented CDOs.

Going up