@koolchemistry.bsky.social
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We all know that DNA damage in our cells is dangerous - but how about in our food? Postdoc Jinwoo Shin's study shows that DNA in some foods is highly damaged by cooking and that it may be hazardous to us -
pubs.acs.org/doi/10.1021/acs.jafc.5c08138
6 days ago
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Our study of pseudouridines in RNA was just published - it turns out that they stabilize RNA from cleavage by having much less nucleophilic 2'-OH groups:
pubs.acs.org/doi/10.1021/acscentsci.5c01345
12 days ago
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I also had the privilege of speaking at the Samsung Science & Technology Foundation Global Research Symposium on Chemical Biology a few days ago in San Diego. It was packed with great research and discussions. A belated thanks to @Samsung
13 days ago
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I attended and spoke at the ACS Western Regional meeting this weekend - thanks to @ByronPurse for the invitation and for organizing a fun session on nucleoside and nucleic acids chemistry!
13 days ago
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Using a DNA-catalyst conjugate to place aryl groups at specific sequences in RNA - Congrats to Sumon Pratihar for leading the work!
doi.org/10.1002/anie.202515681
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Sequence‐Specific Installation of Aryl Groups in RNA via DNA‐Catalyst Conjugates
DNA oligonucleotides carrying amine nucleophilic catalysts are employed to deliver aryl groups to complementary sites in RNA under physiological conditions. The strategy can be used to sequence-speci...
https://doi.org/10.1002/anie.202515681
about 1 month ago
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New and simple chemical modifications to poly(A) tails extend protein expression -- a really easy one-pot method Great work by Linglan Fang and Wenrui Zhong in our lab!
doi.org/10.1021/jacs.5c11900
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Localized 2′-OH Acylation at Poly(A) Extends RNA Translation
The potential of coding RNAs as a general therapeutic modality is limited by their short intracellular lifetime. Here, we investigate the effects of localized post-transcriptional RNA modification on ...
https://doi.org/10.1021/jacs.5c11900
2 months ago
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Spoke at Monday's ACS symposium in honor of Peter Dervan's birthday - it was a great time seeing Peter, Jackie, and the many alums who he trained
8 months ago
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Congratulations to Yixuan (Edward) Gao for publication of his paper on the first SMUG1 small molecule activator - it upregulates pyrimidine repair in cellular models.
doi.org/10.1016/j.dnarep.2025.103809
9 months ago
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...and then I told it to give it the correct twist - not a particularly good result
11 months ago
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so I asked ChatGPT to make a cartoon of DNA - and it made it left handed...
11 months ago
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this one looks AI generated -not a helix, but looks helix-y
11 months ago
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Congrats to Edward Gao on the publication of his paper - an improved synthesis of damaged pyrimidines - doi: 10.1080/15257770.2024.2437038
11 months ago
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when a helix is not a helix
12 months ago
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DNA Publicity Art of the Day: ✘ left-hand twist ✅ dryer hose construction
12 months ago
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inaccurate DNA art of the day: gives new meaning to "DNA damage"
12 months ago
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Very small RNA-reactive reagents can map RNA in crowded spaces in the cell - congrats to Dr. Lu Xiao! doi: 10.1016/j.chembiol.2024.09.009
12 months ago
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